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Parkinson's Disease research

By curious2 following x   2015 Jan 27, 12:31am 48,703 views   92 comments   watch   sfw   quote     share    

I've been reading a lot about Parkinson's Disease research, including especially stem cell research. "Now that the president is in favour, [advocate Michael J] Fox observes wryly, "there is no money" for Congress to pay for it." Am I the only one to notice this pattern: when R's are in charge, they call stem cell research "immoral" (though they launch phony wars killing thousands of people including children); when D's are in charge, they call stem cell research "unaffordable" (though they launch infinite mandatory spending on entrenched industry revenue models)? Are there any SF Bay area companies researching a cure for Parkinson's Disease, and what experience have they had?

Update 2016: in addition to the continuously updated list of projects in this thread, anyone interested in this topic should see the Michael J. Fox Foundation site.

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81   curious2   ignore (0)   2017 May 24, 3:33pm   ↑ like (1)   ↓ dislike (0)   quote   flag        

"Doxycycline Prevents Nerve Cell Damage in Mice with Parkinson’s"

No drug is yet proven and approved to slow the progression of Parkinson's Disease. Isradipine is approved for other purposes and is currently in stage III trials regarding Parkinson's Disease. Doxycycline is also approved for other purposes but has yet to begin clinical trials for Parkinson's disease. Physical exercise is probably the best known way to slow the progression of Parkinson's Disease, but it does not work perfectly, and many patients have other problems that limit physical exercise.

83   curious2   ignore (0)   2017 Jun 29, 1:26pm   ↑ like (0)   ↓ dislike (0)   quote   flag        

MellyRandy says

the disease is totally reversed!! Visit there website

@Patrick, the Parkinson's spammer has returned. I do wish PatNet had a link to delete specific comments or move them to an "off topic" thread.

84   curious2   ignore (0)   2017 Jun 29, 1:30pm   ↑ like (2)   ↓ dislike (0)   quote   flag        

"A Confused Immune System Could Be Behind Parkinson's Disease
"Our findings show that two fragments of alpha-synuclein, a protein that accumulates in the brain cells of people with Parkinson's, can activate the T cells involved in autoimmune attacks," said Sulzer.

So it seems as if T-cells might be fooled into thinking the body's dopamine producing brain cells are foreign due to a build-up of alpha-synculein, and somehow attacking them.

Genetic studies have also shown Parkinson's disease is linked with a variation in genes active in the immune response, adding further reason to suspect mistaken T-cells are responsible for the destruction of the brain's nerve cells.

"It remains to be seen whether the immune response to alpha-synuclein is an initial cause of Parkinson's, or if it contributes to neuronal death and worsening symptoms after the onset of the disease," said researcher Alessandro Sette from the La Jolla Institute for Allergy and Immunology.

In recent years, the evidence has been mounting linking the gut with Parkinson's disease, with gut bacteria stirring up trouble, and possibly affecting the brain via the vagus nerve."

"The rogue protein behind Parkinson’s disease may also protect your gut

The hallmark brain damage in Parkinson’s disease is thought to be the work of a misfolded, rogue protein that spreads from brain cell to brain cell like an infection. Now, researchers have found that the normal form of the protein—α-synuclein (αS)—may actually defend the intestines against invaders by marshaling key immune cells. But chronic intestinal infections could ultimately cause Parkinson’s, the scientists suggest, if αS migrates from overloaded nerves in the gut wall to the brain.

“The gut-brain immune axis seems to be on a cusp of an explosion of new insights, and this work offers an exceptionally exciting new hypothesis,” says Charles Bevins, an expert in intestinal immunity at the University of California, Davis, who was not involved with the study."

85   curious2   ignore (0)   2017 Jun 29, 5:39pm   ↑ like (0)   ↓ dislike (0)   quote   flag        

anonymous says

curious2 - Not sure if you have read this yet.

Thanks - yes - yet another argument against the "low fat" diet craze.

86   curious2   ignore (0)   2017 Jun 29, 5:48pm   ↑ like (0)   ↓ dislike (0)   quote   flag        

VERY interesting study "is currently recruiting participants" with early PD (diagnosed within the last three years) to test an already available dietary supplement called inosine:

"A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial to determine whether oral inosine dosed to moderately elevate serum urate (from ≤5.7 mg/dL to 7.1-8.0 mg/dL) over 2 years slows clinical decline in early PD."

Centers include UCSF.

Unlike some other studies, I would definitely recommend anyone eligible consider enrolling in this particular study. The people involved are highly reputable, the drug is already widely used for other purposes and thus has a well known safety profile, and results are due in 2020, sooner than almost anything else.

From the Michael J. Fox Foundation: "The Phase II study funding of more than $5 million was MJFF's largest single grant at that time. MJFF also supported early pre-clinical work investigating the mechanism of urate in neuroprotection and studies into the interaction of inosine with diet and with other Parkinson's medication. In addition, we are funding a sub-study within SURE-PD3 to collect biospecimen samples from participants, including plasma and DNA, for future biomarker research.

SURE-PD3 will also collect additional data from some participants using the smartphone app mPower, which uses phone sensors to track symptoms of PD. Integrating wearable technology into SURE-PD3 may bolster participant engagement and can provide researchers with greater information on how the study drug affects the progression of motor symptoms.

Individuals diagnosed with PD within the past three years who have low blood urate levels and show dopamine loss on an imaging DaTscan, among other criteria, are eligible for the SURE-PD3 trial."

87   elliemae   ignore (0)   2017 Jun 29, 11:06pm   ↑ like (1)   ↓ dislike (0)   quote   flag        

It'll be interesting to see where the healthcare shitstorm ends. Seems to me that the Repubs are more interested in repealing Obamacare than in fixing it or finding a suitable alternative. With a president that is childish and vindictive this is what we're stuck with. Fuck

89   curious2   ignore (0)   2017 Aug 8, 6:37am   ↑ like (0)   ↓ dislike (0)   quote   flag        

Tissue Nanotransfection (TNT) has broad potential extending far beyond Parkinson's, but so far it's only been tried in mice and pigs, so I'll comment here rather than start a new Post. The reseaerch team at Ohio State University have applied to FDA to start human trials next year.

"Tissue Nanotransfection (TNT), injects genetic code into skin cells, turning those skin cells into other types of cells required for treating diseased conditions.
Researchers at The Ohio State University Wexner Medical Center and Ohio State's College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient's own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.

Results of the regenerative medicine study published in the journal Nature Nanotechnology.

"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said Dr. Chandan Sen, director of Ohio State's Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State's College of Engineering in collaboration with Ohio State's Nanoscale Science and Engineering Center.

Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

The (free) Science Daily article excerpted above contains a link directly to the full Nature Nanotechnology article, which may require a subscription.

92   Aphroman   ignore (6)   2018 May 24, 3:34am   ↑ like (1)   ↓ dislike (0)   quote   flag        

Outside of the Shithole American Police State, researchers are showing potential for Cannabis to combat Parkinsons


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