Alzheimer’s may be able to spread through blood transfusions ? Some other related news on Alzheimer's
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Alzheimer’s may be able to spread through blood transfusions ? Some other related news on Alzheimer's

By anonymous following x   2017 Nov 1, 2:16am 57 views   0 comments   watch   quote     share    


A study has found that an Alzheimer’s protein can spread between mice that share a blood supply, causing brain degeneration.

We already know from prion diseases like Creutzfeldt-Jakob Disease (CJD) that misfolded proteins can spread brain diseases. Variant CJD can spread through meat products or blood transfusions infected with so-called prion proteins, for example.

Like CJD, Alzheimer’s also involves a misfolded protein called beta-amyloid. Plaques of this protein accumulate in the brains of people with the illness, although we still don’t know if the plaques cause the condition, or are merely a symptom.

There has been evidence that beta-amyloid may spread like prions. Around 50 years ago, many people with a growth disorder were treated with growth hormone taken from cadavers. Many of the recipients went on to develop CJD, as these cadavers turned out to be carrying prions. But decades later, it emerged in postmortems that some of these people had also developed Alzheimer’s plaques, despite being 51 or younger at the time.

Protein plaques

The team behind this work raised the possibility that some medical or surgical procedures may pose a risk.

Now a study has found that, when a healthy mouse is conjoined with a mouse with Alzheimer’s plaques, it will eventually start to develop plaques of beta-amyloid protein in its own brain. When the plaques form in healthy mice this way, their brain tissue then starts dying.

This suggests that Alzheimer’s can indeed spread via the beta-amyloid protein in blood. “The protein can get into the brain from a connected mouse and cause neurodegeneration,” says Weihong Song at the University of British Columbia in Vancouver, who led the work.

Song’s team conducted their study on mice with a gene that makes the human version of beta-amyloid, because mice don’t naturally develop Alzheimer’s. This gene enabled mice to develop brain plaques similar to those seen in people, and to show the same pattern of neurodegeneration.

These findings contradict a study earlier this year by Edgren and his colleagues, which tracked 2.1 million recipients of blood transfusions across Sweden and Denmark. They found that people who received blood from people with Alzheimer’s didn’t seem to be at any greater risk of developing the disease

Song thinks researchers and doctors should pay more attention to beta-amyloid in the blood, which could potentially be used to diagnose the disease. One of the reasons it has been difficult to treat Alzheimer’s is the difficulty of designing drugs that can cross the brain’s protective barrier. It may be easier to target the protein in the bloodstream, which could have knock-on effects for the brain, says Song.

https://www.newscientist.com/article/2151909-alzheimers-may-be-able-to-spread-through-blood-transfusions/

Predicting Alzheimer's:

New Alzheimer’s Blood Test Can Predict Onset Of Disease, Researchers Say.

A newly developed blood test technology is said to be capable of predicting the onset of Alzheimer’s disease. The technology is claimed to produce similar diagnostic results as amyloid positron emission tomography scans.

The Seoul National University research team’s invention could pave the way for early diagnosis of Alzheimer’s disease and better treatment planning. It could also end up to be a more affordable alternative than the pricey, high-end brain scans that are conventionally used for the detection and diagnosis of the disorder among living patients.

South Korea’s Ministry of Science and ICT says the new blood testing technology was found to be just as reliable as amyloid positron emission tomography scans in detecting Alzheimer’s. To be specific, the blood test is said to be 90 percent accurate in diagnosing the disease compared to a PET scan.

http://www.ibtimes.com/new-alzheimers-blood-test-can-predict-onset-disease-researchers-say-2605639

Doctors Have Trouble Diagnosing Alzheimer's. AI Doesn't. Algorithms can look at brain scans of people exhibiting memory loss and tell who will develop Alzheimer's disease and who won't.

Separate teams of scientists at the University of Bari in Italy and McGill University in Canada have created artificial intelligence algorithms that can look at brain scans of people who are exhibiting memory loss and tell who will go on to develop full-blown Alzheimer's disease and who won't.

At McGill, the researchers fed an algorithm 191 PET scans of the brains of patients experiencing a decline in memory and thinking abilities, a condition called mild cognitive impairment. The researchers taught the algorithm which of these people had gone on to develop Alzheimer’s and which had not. The key to telling the two groups apart is a protein called amyloid, which shows up in the brains of people with Alzheimer’s and those with mild cognitive impairment.

https://www.nbcnews.com/mach/science/doctors-have-trouble-diagnosing-alzheimer-s-ai-doesn-t-ncna815561

#Alzheimers #Medicine #SciTech

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