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Newsweek: The Key to Defeating COVID-19 Already Exists. We Need to Start Using It

By Patrick follow Patrick   2020 Jul 26, 11:00pm 263 views   16 comments   watch   nsfw   quote   share    


https://www.newsweek.com/key-defeating-covid-19-already-exists-we-need-start-using-it-opinion-1519535

As professor of epidemiology at Yale School of Public Health, I have authored over 300 peer-reviewed publications and currently hold senior positions on the editorial boards of several leading journals. I am usually accustomed to advocating for positions within the mainstream of medicine, so have been flummoxed to find that, in the midst of a crisis, I am fighting for a treatment that the data fully support but which, for reasons having nothing to do with a correct understanding of the science, has been pushed to the sidelines. As a result, tens of thousands of patients with COVID-19 are dying unnecessarily. Fortunately, the situation can be reversed easily and quickly.

I am referring, of course, to the medication hydroxychloroquine. When this inexpensive oral medication is given very early in the course of illness, before the virus has had time to multiply beyond control, it has shown to be highly effective, especially when given in combination with the antibiotics azithromycin or doxycycline and the nutritional supplement zinc.
1   Blue   ignore (0)   2020 Jul 26, 11:37pm     ↓ dislike (0)   quote   flag      

This low cost drug is widely available in India. By importing, US could have saved billions.
2   Rin   ignore (8)   2020 Jul 27, 3:24pm     ↓ dislike (0)   quote   flag      

Yep, no news there. When a substance can help the Zinc ion cross the cell membrane, it's an antiviral by default. You really don't need more than a bachelors in some science, like chemistry or biochem, to know that.

But wait ... those who argue against this say ... "I believe in the science!"

Frigging loser and hypocrite, because you know NO SCIENCE, got it, shithead!
3   MrEd   ignore (2)   2020 Jul 27, 9:01pm     ↓ dislike (0)   quote   flag      

Well, these guys know science...

https://www.nejm.org/doi/full/10.1056/NEJMoa2019014
July 23, 2020
DOI: 10.1056/NEJMoa2019014

CONCLUSIONS
Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. (Funded by the Coalition Covid-19 Brazil and EMS Pharma; ClinicalTrials.gov number, NCT04322123. opens in new tab.)
4   MrEd   ignore (2)   2020 Jul 27, 9:03pm     ↓ dislike (0)   quote   flag      

Yeah, I'll believe some anonymous internet poster on an anonymous internet forum instead of these guys...
https://www.nejm.org/doi/full/10.1056/NEJMoa2019014
5   Tenpoundbass   ignore (14)   2020 Jul 27, 9:10pm     ↓ dislike (0)   quote   flag      

UPDATE: Facebook Deletes the Video! – US Frontline Doctors Hold Presser in Washington DC to Dispel Misinformation on COVID-19 – Including Attacks on Life-Saving HCQ Treatments
https://www.thegatewaypundit.com/2020/07/us-frontline-doctors-hold-presser-washington-dc-dispel-misinformation-covid-9-including-attacks-life-saving-hcq-treatments/
6   MrEd   ignore (2)   2020 Jul 27, 9:24pm     ↓ dislike (0)   quote   flag      

Seriously? Now you're going to take the opinion of a plant who's undercover job is to promote the spread of the Chyna virus???

The Key to Defeating COVID-19 Already Exists. We Need to Start Using It | Opinion
HARVEY A. RISCH, MD, PHD , PROFESSOR OF EPIDEMIOLOGY, YALE SCHOOL OF PUBLIC HEALTH
ON 7/23/20 AT 7:00 AM EDT
7   goofus   ignore (0)   2020 Jul 27, 9:43pm     ↓ dislike (0)   quote   flag      

MrEd says
Well, these guys know science...

https://www.nejm.org/doi/full/10.1056/NEJMoa2019014
July 23, 2020
DOI: 10.1056/NEJMoa2019014

CONCLUSIONS
Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. (Funded by the Coalition Covid-19 Brazil and EMS Pharma; ClinicalTrials.gov number, NCT04322123. opens in new tab.)


The study included very sick people, already hospitalized, on up to 4 liters per minute of oxygen. "The trial included consecutive patients who were 18 years of age or older and who had been hospitalized with suspected or confirmed Covid-19 with 14 or fewer days since symptom onset. Among the reasons for exclusion from the trial were the use of supplemental oxygen at a rate of more than 4 liters per minute as administered by a nasal cannula ..."

Hydroxychloroquine works best prophylactically or within days of symptom onset. Once the virus has fully infected the lungs, HCQ is far less effective.
8   mell   ignore (6)   2020 Jul 27, 9:46pm     ↓ dislike (0)   quote   flag      

MrEd says
Well, these guys know science...

https://www.nejm.org/doi/full/10.1056/NEJMoa2019014
July 23, 2020
DOI: 10.1056/NEJMoa2019014

CONCLUSIONS
Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. (Funded by the Coalition Covid-19 Brazil and EMS Pharma; ClinicalTrials.gov number, NCT04322123. opens in new tab.)


They weren't using it in combination with supplying zinc (e.g. zinc sulfate), either not knowing or willingly. Either way it discredits this study. The evidence in favor of HCQ is overwhelming.
9   Patrick   ignore (1)   2020 Jul 27, 9:47pm     ↓ dislike (0)   quote   flag      

goofus says
The study included very sick people, already hospitalized up to 14 days, and on up to 4 liters per minute of oxygen.


Yes, it's important to give HCQ early.

https://www.henryford.com/news/2020/07/hydro-treatment-study

Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects, according to a new study published by Henry Ford Health System.

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart abnormalities; however, patients were monitored for a heart condition routinely pointed to as a reason to avoid the drug as a treatment for COVID-19.

The study was published today in the International Journal of Infectious Diseases, the peer-reviewed, open-access online publication of the International Society of Infectious Diseases (ISID.org).

Patients treated with hydroxychloroquine at Henry Ford met specific protocol criteria as outlined by the hospital system’s Division of Infectious Diseases. The vast majority received the drug soon after admission; 82% within 24 hours and 91% within 48 hours of admission.
10   mell   ignore (6)   2020 Jul 27, 9:56pm     ↓ dislike (0)   quote   flag      

Right if you administer anti virals after the viral replication explosion, which is in very early onset of symptoms, they are not very useful if not useless (unless it's the exception of a slow and continuous replicator like HIV). This has been known for the longest time as well, that's why you have to take Tamiflu / Oseltamivir within 48, max. 72 hours of onset of symptoms. Another reason to throw this particular study into the trash and suspect possible monetary motives (bribes) here.
11   prodigy   ignore (0)   2020 Jul 28, 8:38am     ↓ dislike (0)   quote   flag      

Maybe that's why CDC is not backing HCQ?
Risk/Reward odds not worth it, especially if one takes it without covid?
12   FuckCCP89   ignore (6)   2020 Jul 28, 8:41am     ↓ dislike (0)   quote   flag      

prodigy says
Risk/Reward odds not worth it, especially if one takes it without covid?


The risks w/o covid are well-known: that medication is older than mammoth shit and has been widely used all over the world, yet somehow there are no reports of people dropping like flies from it.
13   goofus   ignore (0)   2020 Jul 28, 8:45am     ↓ dislike (0)   quote   flag      

prodigy says
HCQ does have serious side effects.
How can one pull an early trigger in a timely manner with HCQ, given the risks?


From the CDC itself, a publication before the HCQ panic, which makes no mention of arrhythmia as a potential risk (at least not for the two month regimen standard for malaria prophylaxis). It does mention headache, stomache ache, dizziness, psoriasis, and the "extremely unlikely" outcome of retinopathy. I woudn't call these "serious side effects," though the side effects of NOT treating coronavirus with HCQ -- hospitalization and potentially death -- are. Recommended dosages are 400 mg once a week, for 7 weeks, near-identical to the Indian COVID prophylaxis:

https://wwwnc.cdc.gov/travel/yellowbook/2020/travel-related-infectious-diseases/malaria
https://www.indiatoday.in/india/story/4-hydroxychloroquine-hcq-doses-coronavirus-healthcare-workers-icmr-1684112-2020-06-01

"CHLOROQUINE AND HYDROXYCHLOROQUINE

Chloroquine phosphate or hydroxychloroquine sulfate (Plaquenil) can be used for prevention of malaria only in destinations where chloroquine resistance is not present (see Chapter 2, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country). Prophylaxis should begin 1–2 weeks before travel to malarious areas. It should be continued by taking the drug once a week, on the same day of the week, during travel in malarious areas and for 4 weeks after a traveler leaves these areas (see Table 4-10 for recommended dosages).

Reported side effects include gastrointestinal disturbance, headache, dizziness, blurred vision, insomnia, and pruritus, but generally, these effects do not require that the drug be discontinued. High doses of chloroquine, such as those used to treat rheumatoid arthritis, have been associated with retinopathy; this serious side effect appears to be extremely unlikely when chloroquine is used for routine weekly malaria prophylaxis. Chloroquine and related compounds have been reported to exacerbate psoriasis. People who experience uncomfortable side effects after taking chloroquine may tolerate the drug better by taking it with meals. As an alternative, the related compound hydroxychloroquine sulfate may be better tolerated."

Hydroxychloroquine
- An alternative to chloroquine for prophylaxis only in areas with chloroquine-sensitive malaria
- 310 mg base (400 mg salt) orally, once/week
- 5 mg/kg base (6.5 mg/kg salt) orally, once/week, up to a maximum adult dose of 310 mg base
- Begin 1–2 weeks before travel to malarious areas. Take weekly on the same day of the week while in the malarious area and for 4 weeks after leaving such areas.
14   APOCALYPSEFUCKisShostakovitch   ignore (55)   2020 Jul 28, 8:46am     ↓ dislike (0)   quote   flag      

From what I've read on real news sources like ALEX! JONES! and BRIETBART!, any time a doctor tries to use it, SOROS! calls him on the phone and threatens to have his offices fire bombed!

THAT'S WHY NO DOCTOR HAS EVER USED IT!

They are being threatened by libby ISIS conspirators who hate FREEDOM! and WHITE! PEOPLE!
15   Onvacation   ignore (6)   2020 Jul 28, 10:46am     ↓ dislike (0)   quote   flag      

prodigy says
Maybe that's why CDC is not backing HCQ?

But they are advocating kids in school.
16   Rin   ignore (8)   2020 Jul 28, 12:34pm     ↓ dislike (0)   quote   flag      

Well, go get yourself some Quercetin, as it also helps with Zinc ion transport and is a cheap OTC supplement (~25 cents/pill) and you don't need to see a doctor for it.

https://pubs.acs.org/doi/10.1021/jf5014633#

Seriously, what are people waiting for?

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