by Rin ➕follow (8) 💰tip ignore
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It's likely herd immunity plus adaptation by the virus.
We all know the mass PCR testing is shotgun and thus, lacks the specificity needed to make delineations but I'm hoping some virologists have better assays, at least in the lab, to tell what's going on, on a smaller subset?
So for each cycle you heat up the sample and double strand become single strand only for the cancer version because you never let it get to 45.2.
https://gothamist.com/news/despite-rising-covid-cases-ny-hospitalizations-have-yet-spike
Excerpt: "Coronavirus cases have been climbing steadily over the past month in New York, but while local public health leaders are watching carefully, they say so far it’s a good sign that relatively few people are getting sick enough to go to the hospital.
“Same as last week, no real changes,” texted one front-line doctor at Maimonides Medical Center, in Borough Park, which has had one of the highest rates of positive COVID-19 tests in the state and is in Brooklyn’s designated red zone.
Jason Molinet, a spokesman for Northwell Health, the state’s largest hospital network, said they have 113 people hospitalized with COVID-19 across 19 of its hospitals. “Our peak in October was 135, and September we were under 100 the whole time – that’s compared with 3,500 COVID patients at the peak last spring.”
Statewide, there are only around 1,000 patients in the hospital, which is fewer than in less populous states, like Wisconsin, Pennsylvania, and Michigan. "
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When one looks at the actual coronavirus itself in PubMed, its mutagenicity appears to be rather high ...
https://pubmed.ncbi.nlm.nih.gov/21593585/
Excerpt: " demonstrate 15- to 20-fold increases in mutation rates, up to 18 times greater than those tolerated for fidelity mutants of other RNA viruses. Thus nsp14-ExoN is essential for replication fidelity, and likely serves either as a direct mediator or regulator of a more complex RNA proofreading machine, a process previously unprecedented in RNA virus biology."
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Ok, so has anyone studied the late winter/early spring 2020 Covid-19 outbreak in NYC and compared it, with the current strain out there in the Big Apple?
What I'm trying to propose goes on the lines of ... is there some herd immunity in New York and the reason why so many new cases in NYC do not have the associated spikes in hospitalizations is that it's a newer strain and that that person already has some prior immunity from the spring incarnation making it less likely for the now, immuno-enchanced patient to go the full monty to being on a respirator in a week or two?
Does anyone know?
Is anyone doing any research on this?
We all know the mass PCR testing is shotgun and thus, lacks the specificity needed to make delineations but I'm hoping some virologists have better assays, at least in the lab, to tell what's going on, on a smaller subset?