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Treating cancer with THC

By Al_Sharpton_for_President follow Al_Sharpton_for_President   2021 Sep 21, 2:09pm 354 views   13 comments   watch   nsfw   quote   share      


In particular, ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD), the main ingredients of Cannabis sativa plants, caused a significant decrease in cell viability and proliferation in a variety of glioblastoma (GBM) cell lines, including SF126, U251, U87, C6, and also primary GBM cells by cell cycle arrest or apoptosis [12–14]. Growth inhibition of U87-MG cell-based tumor xenografts has been reported after THC and CBD exposure by autophagy-mediated apoptosis [14]. Furthermore, CBD has been shown to inhibit the invasion of U87-MG and T98G cells [13]. Remarkably, CBD potentiates the anti-tumor effects of THC apparently via different receptors and signaling pathways [12,14]. It was demonstrated that THC effects were often triggered by CB1 and CB2 receptor activation, but the receptor engaged by CBD was mostly not clarified [14]. Indeed, THC shows a high agonistic activity on CB1 and CB2, while CBD binds to both receptors with a very low binding affinity [17,18]. Addition- ally, THC and CBD also modulate certain orphan receptors, such as GPR55 and GPR18, ion channels, transient receptor potential (TRP) channels in particular, or peroxisome proliferator-activated receptors (PPAR) such as PPARγ [19–21].

https://pubmed.ncbi.nlm.nih.gov/33802282/

Cannabinoid receptor (CB-R) agonists inhibit cancer cell proliferation through various receptor-mediated mechanisms. CB-R agonist induces cancer cell death via apoptosis, mediated by the activation of different transcription factors (proapoptotic Bcl2 family transcription factor and mitogen-activated protein kinase (MAPK) pathway) and de novo synthesis of ceramide and reactive oxygen species (ROS) production. CBs block cancer cells’ proliferation by inhibiting extracellular signal regulated kinase (ERK) signaling. They also reduce cell migration and angiogenesis, inhibiting the focal adhesion kinase/proto-oncogene tyrosine-protein kinase Src/transforming protein RhoA (FAK/SRC/RhoA) pathway. CBs prevent cancer epithelial mesenchymal transition (EMT), inhibiting Wnt/β-catenin pathway, and induce autophagy by activation of mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways. CBs can impair stemness and cancer stem cells’ (CSCs) self-renewal. (Akt (protein kinase B), PI3K (phosphoinositol-3-kinase) Raf (serine/threonine-protein kinase)).

https://pubmed.ncbi.nlm.nih.gov/31979368/


1   AmericanKulak   ignore (1)   2021 Sep 22, 1:24am     ↓ dislike (0)   quote          

I thought legalizing THC was going to cure glaucoma, cystic fibrosis, and a bad case of the gout. So claimed the legalizers.
2   WookieMan   ignore (6)   2021 Sep 22, 1:41am     ↓ dislike (0)   quote          

MisdemeanorRebellionNoCoupForYou says
I thought legalizing THC was going to cure glaucoma, cystic fibrosis, and a bad case of the gout. So claimed the legalizers.

I personally never thought it would cure anything. Maybe anxiety or CBD for some (not all) pain relief. I just think it was stupid for it to be illegal. Alcohol is substantially more damaging. Pot is literally the most harmless mind altering substance of them all.
3   DhammaStep   ignore (0)   2021 Sep 22, 5:19am     ↓ dislike (0)   quote          

From firsthand experience, I'm convinced. I had an awful skin growth/lesion that I went to a dermatologist for. It was bad enough that hair didn't grow on that patch at all. The dermatologist barely glanced at it, and prescribed some bullshit cream that made it look okay for a few hours but didn't make any permanent improvements. He said it was "eczema" even though it didn't behave like eczema at all.

After I found Rick Simpson Oil, it changed drastically. RSO is a highly concentrated cannabis oil that is claimed to cure skin cancer. I applied it daily for a few weeks. Not only did hair begin to grow again on that dried up skin patch, but it began healing. That patch is almost fully healed now, after four years of being a dead and ugly area on my leg.

That being said, it was not a recreational method at all. I believe the concentrated form applied to the problematic area is most effective.
4   WookieMan   ignore (6)   2021 Sep 22, 6:28am     ↓ dislike (0)   quote          

DhammaStep says
That being said, it was not a recreational method at all.

Recreational won't cure much. Anxiety is about the only thing I could think of. My sister now takes it since it's been legal here in IL. Has helped her a lot. She's an attorney with a stressful schedule and recently divorced. I was ridiculed in high school by her for smoking pot and now she's a pot head.

Dosage amount is the biggest problem for anxiety. It helps me chill, but I've been at LAS airport and took too many edibles and kind of freaked out. Was borderline hallucinating. I don't like smoking anymore, but I'd prefer that as the consumption method. Edibles are getting to shroom level at this point. I don't think the quantities are consistent per dose.

I took a decent dosage at a concert out in Missoula, MT. Got back to the hotel after the show and couldn't speak or function. I could not form a sentence. I was full retard and the weird part is I knew I was. It was strange. I kept trying to talk and gave up and went to bed.
5   Shaman   ignore (2)   2021 Sep 22, 8:12am     ↓ dislike (0)   quote          

I’ve found it’s great for a sleep aid, winding down after a long stressful day. Take it half an hour before bed and sleep like a baby. Way better than when I used to use alcohol.
6   WookieMan   ignore (6)   2021 Sep 22, 9:46am     ↓ dislike (0)   quote          

Shaman says
I’ve found it’s great for a sleep aid, winding down after a long stressful day. Take it half an hour before bed and sleep like a baby. Way better than when I used to use alcohol.

I'd agree. It's a great sleep aid depending on the type and quantity of MJ. Better than big Pharma that is likely fucking up your liver as much or more than alcohol.

With kids and a wife that travels a lot I have to be careful. My sleep is too deep after smoking or doing edibles, so I cannot risk missing getting them to school. My boys have only been tardy twice. They both trusted a fart if you catch my drift... lol. My nephew was tardy 12 times in one semester and he took the bus. So that give you an idea of my SIL I mention.

Sorry I rant about this so much to other users with my SIL and nephew. It's been life altering on many levels and is a form of therapy for me to vent here. Had the first months where it was confidence boosting "we're doing the right thing" and now it's setting in that this is likely permanent. Going to FL next Thursday, so hoping that chills me out and I can reset.
7   NuttBoxer   ignore (3)   2021 Sep 22, 10:49am     ↓ dislike (0)   quote          

I saw a documentary about the cancer angle years ago. The doctor was of course not doing the study in the US, and there's hardly any funding for medical usage, and legalization has done little to change that.

From everything I've read, it's the CBD's that do all the work. The psychoactive component(THC), isn't really necessary, except maybe in the case of pain relief? I usually smoke a few nights a week right before bed due to neck and shoulder stiffness, and the headaches that I've started to wake up with. Works great for that, and since mine is a few years old, has more CBN's, so great for sleep.

I fully believe cannabis has the capability to do many of the things people claim, but unfortunately there are few in the field who are truly interested in the medical aspects, and research is WAY behind.
8   mell   ignore (6)   2021 Sep 22, 12:26pm     ↓ dislike (0)   quote          

It's a double edged sword. THC/CBD does depress certain inflammatory markers and tumor/cell growth (and induces apoptosis), but it does so by suppressing the immune system as a whole which is often necessary in fighting cancer cells. So it does not cure cancer on it own, but it def has some therapeutic qualities.
9   Robber Baron Elite Scum   ignore (0)   2022 Jan 2, 9:36pm     ↓ dislike (0)   quote          

mell says
It's a double edged sword. THC/CBD does depress certain inflammatory markers and tumor/cell growth (and induces apoptosis), but it does so by suppressing the immune system as a whole which is often necessary in fighting cancer cells. So it does not cure cancer on it own, but it def has some therapeutic qualities.


Disagree.

Immune system is improved on cannabis.

I have not had a cold in years because of cannabis.
10   Ceffer   ignore (6)   2022 Jan 2, 10:32pm     ↓ dislike (0)   quote          

I have never seen a bong with cancer yet.

Lots of people use it in Santa Cruz, including many geriatric stoners. A friend with pain and difficulty sleeping says it keeps him from overusing narcotics or ibuprofen, which to me would count as a legitimate use. He does not like that it fucks up his already aging memory. It is also great for motion sickness nausea. It is alleged to be effective as a poultice for joint pain.

The cancer angle sounds like marketing puffery for research funding from industry (cures cancer, Alzheimer's etc.).
11   WookieMan   ignore (6)   2022 Jan 2, 10:51pm     ↓ dislike (0)   quote          

Ceffer says
A friend with pain and difficulty sleeping says it keeps him from overusing narcotics or ibuprofen

Yes. My dad was so anti-pot, but when he got near end stage cancer it helped a lot. It was liver cancer so pain killers would have just done more damage to a failing liver as he was taking a ton of other big Pharma pills to treat the cancer.

Ceffer says
It is alleged to be effective as a poultice for joint pain.

Yes. 100% works for me though I have minimal joint pain. Bad knees and ankles, but it's never anything I've taken pills for. THC or CBD helped quite a bit for me though when I felt I needed it.

Ceffer says
It is also great for motion sickness nausea.

I know there was nothing to do so pirates and sailers would drink. But I do find alcohol helps with both these symptoms (in moderation) more than weed (for me), so I always question if they were on to something. I keep a slight buzz when cruising from morning to night. Never have felt remotely sea sick. Wife does all the dramamine, things behind the ears, bracelets, etc. and is usually sick until she starts having drinks. I think you need to have a baseline tolerance of 6-8 beers in a day and not be smashed.

I'm not a fan of flying stoned and I don't think CBD would make a difference there. I get more anxiety and paranoid popping a few edibles before a flight. Small seats and masks now are torture. We'll grab a few beers or mimosas before the flight and try to sleep on a buzz as usually 3-4 hours is the max flight for us.
12   Onvacation   ignore (7)   2022 Jan 3, 6:53am     ↓ dislike (0)   quote          

WookieMan says
I think you need to have a baseline tolerance of 6-8 beers in a day and not be smashed.

AKA alcoholism.
13   WookieMan   ignore (6)   2022 Jan 3, 9:06am     ↓ dislike (0)   quote          

Onvacation says
WookieMan says
I think you need to have a baseline tolerance of 6-8 beers in a day and not be smashed.

AKA alcoholism.

Not suggesting daily on a consistent basis. Just for a trip. The ability to be able to consume that occasionally and not be a fucktard I guess is my point. Even 8 beers a day over a week of travel over a 16 hour day awake is literally a nothing burger if spacing it out. I know people that don't ever drink, but have no issue with a 12 pack tailgating for a day and can keep their shit together.

I'm talking tolerance of alcohol, not tolerance because of excess consumption over time. I'm sure we all know the girl that has 2 shots and was falling down drunk or starting a fight. That was the tolerance I was referring to. The amounts I mention drinking would be stupid much more than 7-10 days. Even then I'd take a break within the trip.

My BIL just died from alcoholism at 40. So I'm fully aware of what is too much. My comment was more about travel and not normal daily living. People gonna drink on vacation and it's helped with at sea days for me is all.

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