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Vitamin D Could Prevent 30,000 Cancer Deaths Per Year in Germany Alone
Over 900 studies show anti-cancer activity of vitamin D across most cancer types, and randomized controlled trials demonstrate a ~13% reduction in cancer mortality.
NICOLAS HULSCHER, MPH
DEC 29

维生素 D 可挽救生命 因利益冲突被公共卫生政策继续忽视 而mRNA注射被煽动 医疗经济布局恶性循环。记者：韩荣利

Vitamin D can save lives, yet it continues to be ignored by public health policy due to conflicts of interest, while mRNA injections are being promoted, creating a vicious cycle driven by the medical–economic system.
Reporter: Han Rongli

仅在德国，维生素 D 每年就能预防 30,000 例癌症死亡
超过 900 项研究表明维生素 D 对大多数癌症类型具有抗癌活性，随机对照试验表明癌症死亡率可降低约 13%。
尼古拉斯·胡尔舍，公共卫生硕士
12月29日

https://open.substack.com/pub/petermcculloughmd/p/vitamin-d-could-prevent-30000-cancer

Vitamin D Could Prevent 30,000 Cancer Deaths Per Year in Germany Alone
Over 900 studies show anti-cancer activity of vitamin D across most cancer types, and randomized controlled trials demonstrate a ~13% reduction in cancer mortality.
NICOLAS HULSCHER, MPH
DEC 29

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by Nicolas Hulscher, MPH

Modern cancer policy is dominated by expensive drugs, marginal survival gains, and soaring end-of-life costs. Yet quietly, a low-cost and widely accessible intervention has been sitting in plain sight.

A peer-reviewed analysis published in Molecular Oncology examined what would happen if adults aged 50 and older received routine vitamin D supplementation at modest daily doses. The results are deeply inconvenient for a system built around high-cost treatment rather than prevention.

Using national mortality data and randomized controlled trial meta-analyses, researchers estimated that daily vitamin D supplementation could:

Prevent ~30,000 cancer deaths per year in Germany alone
Save ~322,000 life-years annually
Reduce overall cancer mortality by ~13%, consistent across multiple RCT meta-analyses

Lower total healthcare spending, even after accounting for the cost of supplementation
Annual supplementation costs (~$1.0 billion per year) were outweighed by reductions in end-of-life cancer care, producing net savings of ~$280 million annually.

For context, many modern oncology drugs cost tens of thousands of dollars per patient while extending survival by weeks or months. By contrast, vitamin D supplementation:

Costs ~$11–$55 per person per year
Demonstrates actual mortality reduction
Remains highly cost-effective even under worst-case assumptions
Even when researchers ignored all cancer-care cost savings, the cost per life-year saved was approximately $3,100 — far below standard cost-effectiveness thresholds used to justify new cancer drugs.

Yet despite widespread deficiency, routine vitamin D supplementation remains absent from most cancer-prevention strategies — while healthcare systems continue to pour resources into late-stage treatment with diminishing returns.

Cancers Vitamin D Has Shown Benefit Against

Beyond population-level mortality reductions, a large and growing body of mechanistic, clinical, and translational evidence shows vitamin D activity across multiple cancer types. A 2023 peer-reviewed synthesis of over 900 recent studies highlights consistent anti-cancer effects mediated through vitamin D receptor (VDR) signaling, immune modulation, and tumor microenvironment control.

.Vitamin D has demonstrated protective or therapeutic effects in:

Breast cancer (including triple-negative subtypes)
Prostate cancer
Colorectal cancer
Ovarian cancer
Glioblastoma (brain cancer)
Melanoma
Squamous cell carcinoma (skin and head & neck)
Head and neck cancers
Bladder cancer
Non-small cell lung cancer
Multiple myeloma
Osteosarcoma (bone cancer)
Across these cancers, vitamin D has been shown to:

Suppress tumor growth and proliferation
Induce apoptosis and ferroptosis
Inhibit metastasis and epithelial-to-mesenchymal transition (EMT)
Improve response to chemotherapy and immunotherapy
Reduce treatment resistance
Improve survival in deficient patients
Importantly, low vitamin D status is repeatedly associated with worse prognosis, more aggressive disease, and reduced survival — while adequate levels or supplementation are linked to improved outcomes.

Some of the most powerful cancer-prevention tools are neither novel nor profitable.

Vitamin D is inexpensive. It is biologically active across immune, inflammatory, and cellular regulatory pathways. And according to randomized trial evidence, it saves lives — at scale.

The only real question left is why public health policy continues to ignore it.

Nicolas Hulscher, MPH

Epidemiologist and Foundation Administrator, McCullough Foundation

www.mcculloughfnd.org

Please consider following both the McCullough Foundation and my personal account on X (formerly Twitter) for further content.

仅在德国，维生素 D 每年就能预防 30,000 例癌症死亡
超过 900 项研究表明维生素 D 对大多数癌症类型具有抗癌活性，随机对照试验表明癌症死亡率可降低约 13%。
尼古拉斯·胡尔舍，公共卫生硕士
12月29日

在应用程序中阅读

作者：Nicolas Hulscher，公共卫生硕士

现代癌症政策以昂贵的药物、边际生存收益和飙升的临终费用为主导。 然而，一种低成本且广泛可及的干预措施悄然出现在人们的视线中。

发表在《分子肿瘤学》上的一项同行评审分析研究了如果 50 岁及以上的成年人定期补充适量的每日维生素 D 会发生什么情况。 对于一个围绕高成本治疗而不是预防建立的系统来说，结果是非常不方便的。

研究人员利用全国死亡率数据和随机对照试验荟萃分析估计，每日补充维生素 D 可以：

仅在德国每年就可预防约 30,000 例癌症死亡
每年节省约 322,000 生命年
将总体癌症死亡率降低约 13%，与多项 RCT 荟萃分析一致

即使考虑了补充剂的成本，医疗保健总支出仍然较低
临终癌症护理的减少抵消了年度补充剂成本（每年约 10 亿美元），每年净节省约 2.8 亿美元。

就背景而言，许多现代肿瘤药物每位患者花费数万美元，同时可以延长患者的生存期数周或数月。 相比之下，补充维生素 D：

每人每年约 11-55 美元
显示实际死亡率降低
即使在最坏情况的假设下仍保持高度成本效益
即使研究人员忽略了所有癌症治疗成本节省，每生命年节省的成本也约为 3,100 美元——远低于用于证明新抗癌药物合理性的标准成本效益阈值。

然而，尽管维生素 D 普遍缺乏，但大多数癌症预防策略中仍然缺乏常规维生素 D 补充，而医疗保健系统继续将资源投入后期治疗，但回报却递减。

维生素 D 已显示出对癌症有益

除了人群死亡率降低之外，大量且不断增长的机械、临床和转化证据表明维生素 D 在多种癌症类型中都具有活性。 2023 年对 900 多项近期研究进行的同行评审综合报告强调了通过维生素 D 受体 (VDR) 信号、免疫调节和肿瘤微环境控制介导的一致抗癌作用。

.维生素 D 在以下方面已被证明具有保护或治疗作用：

乳腺癌（包括三阴性亚型）
前列腺癌
结直肠癌
卵巢癌
胶质母细胞瘤（脑癌）
黑色素瘤
鳞状细胞癌（皮肤癌和头颈部癌）
头颈癌
膀胱癌
非小细胞肺癌
多发性骨髓瘤
骨肉瘤（骨癌）
在这些癌症中，维生素 D 已被证明可以：

抑制肿瘤生长和增殖
诱导细胞凋亡和铁死亡
抑制转移和上皮间质转化（EMT）
改善对化疗和免疫治疗的反应
降低治疗抵抗力
提高缺陷患者的生存率
重要的是，低维生素 D 状态反复与较差的预后、更具侵袭性的疾病和降低的生存率相关，而充足的维生素 D 水平或补充则可改善预后。

一些最强大的癌症预防工具既不新颖也不有利可图。

维生素 D 很便宜。 它在免疫、炎症和细胞调节途径中具有生物活性。 根据随机试验证据，它可以大规模地挽救生命。

剩下的唯一真正的问题是为什么公共卫生政策继续忽视它。

尼古拉斯·哈尔舍，公共卫生硕士

麦卡洛基金会流行病学家兼基金会管理员

www.mcculloughfnd.org

请考虑关注 McCullough 基金会和我在 X 上的个人帐户（以前称为 Twitter）以获取更多内容。