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Journalist Overdoses on Vitamin D OMEGA-3: Taking 16 Capsules Daily for Three Months, Health Index Significantly Improves
2026 Jan 12, 2:58pm 122 views 11 comments
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1
HANrongli
2026 Jan 13, 10:00pm
This American woman loses it after seeing all the pills that doctors have prescribed to her friend.
She shows that her friend has been prescribed a pill for basically everything, and had problems she was able to solve just by changing her diet instead of using all of this medication. 这位美国妇女在看过医生给她朋友开的所有药物后失去了它。
她表明，她的朋友几乎所有的事情都开药丸，并且她只需改变饮食而不是使用所有这些药物就能解决问题。 https://substack.com/@stopthoseshots/note/c-199128978
This American woman loses it after seeing all the pills that doctors have prescribed to her friend.
She shows that her friend has been prescribed a pill for basically everything, and had problems she was able to solve just by changing her diet instead of using all of this medication. 这位美国妇女在看过医生给她朋友开的所有药物后失去了它。
她表明，她的朋友几乎所有的事情都开药丸，并且她只需改变饮食而不是使用所有这些药物就能解决问题。 https://substack.com/@stopthoseshots/note/c-199128978
2
HANrongli
2026 Jan 13, 10:05pm
The data they WON'T share.
Houston Methodist led the charge on mandates but won’t show the results. 💉🧂Talking with Jillian Michaels about the need for transparency here! 他们不会分享的数据。
休斯敦卫理公会在强制执行方面处于领先地位，但不会显示结果 💉🧂。与 Jillian Michaels 讨论这里透明度的必要性！
https://substack.com/@marybowdenmd/note/c-199498176
The data they WON'T share.
Houston Methodist led the charge on mandates but won’t show the results. 💉🧂Talking with Jillian Michaels about the need for transparency here! 他们不会分享的数据。
休斯敦卫理公会在强制执行方面处于领先地位，但不会显示结果 💉🧂。与 Jillian Michaels 讨论这里透明度的必要性！
https://substack.com/@marybowdenmd/note/c-199498176
3
HANrongli
2026 Jan 13, 10:10pm
The COVID era exposed a diagnostic failure that can no longer be ignored: PCR-based testing is not a true “gold standard” for clinical infection diagnosis. PCR is widely treated as definitive, but mechanistically it is not an identification method—it is an amplification step that simply makes more copies of genetic material. The real weakness comes from what many systems use after amplification: probe-based fluorescence detection, which generates a “signal” without actually confirming what is present. That is how medicine ends up with false positives, misclassification, and policy decisions built on unstable data.
In my interview with Dr. Roger Hodkinson—a highly respected pathologist and Chairman of MultiSeq—he explains why the PCR problem is structural: probe-based testing functions like a “lock-and-key,” where partial matches can still trigger a positive signal. Even worse, infectious syndromes (cough/cold, diarrhea, suspected STI) are rarely caused by only one organism—yet most PCR workflows are narrow, slow, and often treated as confirmatory when they’re not. In practice, clinicians are forced into an “educated guess” model because results frequently come back days later and only cover a limited scope.
MultiSeq is attempting to replace this entire model with something fundamentally different: sequence-confirmed diagnosis. Instead of relying on probe fluorescence to “suggest” identity, it uses modified Sanger sequencing to directly read the nucleotide sequence and confirm which pathogen is actually present. Traditional Sanger sequencing is widely recognized as a gold-standard method because it produces a verifiable sequence output (an electropherogram), but historically it was too limited for real-world diagnostics because it could only handle one target per test. MultiSeq’s central claim is that its approach enables multiplex Sanger sequencing—meaning it can generate confirmatory sequences for multiple pathogens from a single patient sample at the same time.
Dr. Hodkinson also highlights a major vulnerability in molecular testing: cross-contamination. Opening sample tubes can generate aerosols that contaminate other samples, driving additional false positives. MultiSeq describes an internal “bar-code”–style approach designed to detect this kind of contamination, strengthening confidence that a reported pathogen truly came from that patient’s specimen.
The bottom line is simple: a flawed testing foundation produces flawed medicine and flawed policy. PCR has been misused as a confirmatory diagnostic standard. If a sequencing-confirmation platform like MultiSeq can be validated and scaled for real clinical throughput, it could represent a substantial upgrade in infectious disease diagnostics and potentially help correct the damage caused by years of overreliance on non-confirmatory testing.
You can learn more here: https://multiseq.bio/
You can contact Dr. Roger Hodkinson on his email here: roger@multiseq.ca 新冠时代暴露了一个不能再忽视的诊断失败：基于PCR的检测并不是临床感染诊断的真正“金标准”。 PCR 被广泛认为是确定性的，但从机制上讲，它不是一种识别方法，而是一个扩增步骤，只是复制更多的遗传物质。 真正的弱点来自许多系统在扩增后使用的内容：基于探针的荧光检测，它会生成“信号”，但实际上并不能确认存在的内容。 这就是医学最终会出现误报、错误分类以及基于不稳定数据的政策决策的原因。
在我对备受尊敬的病理学家兼 MultiSeq 董事长 Roger Hodkinson 博士的采访中，他解释了为什么 PCR 问题是结构性的：基于探针的测试功能就像“锁和钥匙”一样，部分匹配仍然可以触发阳性信号。 更糟糕的是，感染综合症（咳嗽/感冒、腹泻、疑似性传播感染）很少仅由一种微生物引起，但大多数 PCR 工作流程狭窄、缓慢，并且在并非如此的情况下通常被视为确诊。 在实践中，临床医生被迫采用“有根据的猜测”模型，因为结果经常在几天后返回，并且只涵盖有限的范围。
MultiSeq 试图用根本不同的东西取代整个模型：序列确认诊断。 它不依赖探针荧光来“暗示”身份，而是使用改良的桑格测序直接读取核苷酸序列并确认实际存在哪种病原体。 传统的桑格测序被广泛认为是一种黄金标准方法，因为它产生可验证的序列输出（电泳图），但从历史上看，它对于现实世界的诊断来说过于有限，因为它每次测试只能处理一个目标。 MultiSeq 的核心主张是，其方法可以实现多重桑格测序，这意味着它可以同时从单个患者样本中生成多种病原体的确认序列。
霍金森博士还强调了分子检测的一个主要漏洞：交叉污染。 打开样品管会产生气溶胶，污染其他样品，从而导致额外的误报。 MultiSeq 描述了一种内部“条形码”式方法，旨在检测这种污染，增强人们对报告的病原体确实来自该患者样本的信心。
底线很简单：有缺陷的测试基础会产生有缺陷的医学和有缺陷的政策。 PCR 已被误用为确证诊断标准。 如果像 MultiSeq 这样的测序确认平台能够针对真实的临床通量进行验证和扩展，那么它可能代表传染病诊断的重大升级，并可能有助于纠正多年来过度依赖非确认测试所造成的损害。
您可以在这里了解更多信息：https://multiseq.bio/
您可以通过电子邮件联系 Roger Hodkinson 博士：roger@multiseq.ca https://open.substack.com/pub/petermcculloughmd/p/the-replacement-for-pcr-tests-has
The COVID era exposed a diagnostic failure that can no longer be ignored: PCR-based testing is not a true “gold standard” for clinical infection diagnosis. PCR is widely treated as definitive, but mechanistically it is not an identification method—it is an amplification step that simply makes more copies of genetic material. The real weakness comes from what many systems use after amplification: probe-based fluorescence detection, which generates a “signal” without actually confirming what is present. That is how medicine ends up with false positives, misclassification, and policy decisions built on unstable data.
In my interview with Dr. Roger Hodkinson—a highly respected pathologist and Chairman of MultiSeq—he explains why the PCR problem is structural: probe-based testing functions like a “lock-and-key,” where partial matches can still trigger a positive signal. Even worse, infectious syndromes (cough/cold, diarrhea, suspected STI) are rarely caused by only one organism—yet most PCR workflows are narrow, slow, and often treated as confirmatory when they’re not. In practice, clinicians are forced into an “educated guess” model because results frequently come back days later and only cover a limited scope.
MultiSeq is attempting to replace this entire model with something fundamentally different: sequence-confirmed diagnosis. Instead of relying on probe fluorescence to “suggest” identity, it uses modified Sanger sequencing to directly read the nucleotide sequence and confirm which pathogen is actually present. Traditional Sanger sequencing is widely recognized as a gold-standard method because it produces a verifiable sequence output (an electropherogram), but historically it was too limited for real-world diagnostics because it could only handle one target per test. MultiSeq’s central claim is that its approach enables multiplex Sanger sequencing—meaning it can generate confirmatory sequences for multiple pathogens from a single patient sample at the same time.
Dr. Hodkinson also highlights a major vulnerability in molecular testing: cross-contamination. Opening sample tubes can generate aerosols that contaminate other samples, driving additional false positives. MultiSeq describes an internal “bar-code”–style approach designed to detect this kind of contamination, strengthening confidence that a reported pathogen truly came from that patient’s specimen.
The bottom line is simple: a flawed testing foundation produces flawed medicine and flawed policy. PCR has been misused as a confirmatory diagnostic standard. If a sequencing-confirmation platform like MultiSeq can be validated and scaled for real clinical throughput, it could represent a substantial upgrade in infectious disease diagnostics and potentially help correct the damage caused by years of overreliance on non-confirmatory testing.
You can learn more here: https://multiseq.bio/
You can contact Dr. Roger Hodkinson on his email here: roger@multiseq.ca 新冠时代暴露了一个不能再忽视的诊断失败：基于PCR的检测并不是临床感染诊断的真正“金标准”。 PCR 被广泛认为是确定性的，但从机制上讲，它不是一种识别方法，而是一个扩增步骤，只是复制更多的遗传物质。 真正的弱点来自许多系统在扩增后使用的内容：基于探针的荧光检测，它会生成“信号”，但实际上并不能确认存在的内容。 这就是医学最终会出现误报、错误分类以及基于不稳定数据的政策决策的原因。
在我对备受尊敬的病理学家兼 MultiSeq 董事长 Roger Hodkinson 博士的采访中，他解释了为什么 PCR 问题是结构性的：基于探针的测试功能就像“锁和钥匙”一样，部分匹配仍然可以触发阳性信号。 更糟糕的是，感染综合症（咳嗽/感冒、腹泻、疑似性传播感染）很少仅由一种微生物引起，但大多数 PCR 工作流程狭窄、缓慢，并且在并非如此的情况下通常被视为确诊。 在实践中，临床医生被迫采用“有根据的猜测”模型，因为结果经常在几天后返回，并且只涵盖有限的范围。
MultiSeq 试图用根本不同的东西取代整个模型：序列确认诊断。 它不依赖探针荧光来“暗示”身份，而是使用改良的桑格测序直接读取核苷酸序列并确认实际存在哪种病原体。 传统的桑格测序被广泛认为是一种黄金标准方法，因为它产生可验证的序列输出（电泳图），但从历史上看，它对于现实世界的诊断来说过于有限，因为它每次测试只能处理一个目标。 MultiSeq 的核心主张是，其方法可以实现多重桑格测序，这意味着它可以同时从单个患者样本中生成多种病原体的确认序列。
霍金森博士还强调了分子检测的一个主要漏洞：交叉污染。 打开样品管会产生气溶胶，污染其他样品，从而导致额外的误报。 MultiSeq 描述了一种内部“条形码”式方法，旨在检测这种污染，增强人们对报告的病原体确实来自该患者样本的信心。
底线很简单：有缺陷的测试基础会产生有缺陷的医学和有缺陷的政策。 PCR 已被误用为确证诊断标准。 如果像 MultiSeq 这样的测序确认平台能够针对真实的临床通量进行验证和扩展，那么它可能代表传染病诊断的重大升级，并可能有助于纠正多年来过度依赖非确认测试所造成的损害。
您可以在这里了解更多信息：https://multiseq.bio/
您可以通过电子邮件联系 Roger Hodkinson 博士：roger@multiseq.ca https://open.substack.com/pub/petermcculloughmd/p/the-replacement-for-pcr-tests-has
4
Ceffer
2026 Jan 13, 10:17pm
Ceffer
2026 Jan 13, 10:17pm
During the lockdowns, they did everything they could to keep people from going outdoors and deriving sunlit Vit D. The Globalist eugenicists know the healthful benefits of Vit D, so it is one of their primary targets to reduce natural immunity. One might also say that is a goal of the chemtrailing filtering the sun.
5
HANrongli
2026 Jan 13, 10:17pm
Dr. Peter Hotez was caught red handed… gaslighting families that have had pediatricians kick them out of their practices or worse, had protective services called on them for wanting to opt out of the CDC recommendations. peterhotez says that in Dr’s offices, “there was never coercion.” We know this has been happening for years, but even CBS news reported this was happening as far back as 2012… a survey by the American Journal of Preventative Medicine showed that 25% of pediatricians have fired patients for refusing vaccines. Sounds like coercion to me… who’s gaslighting now?
彼得·霍特兹（Peter Hotez）医生被当场抓获……煤气灯操纵下的家庭被儿科医生踢出诊所，甚至更糟糕的是，因为他们想要选择不接受疾病控制与预防中心（CDC）的建议，保护部门要求他们这样做。 彼得霍特兹说，在博士的办公室里，“从来不存在强迫行为。” 我们知道这种情况已经发生很多年了，但就连哥伦比亚广播公司的新闻也报道说这种情况早在 2012 年就发生过……《美国预防医学杂志》的一项调查显示，25% 的儿科医生因拒绝接种疫苗而解雇了患者。 对我来说听起来像是胁迫……现在是谁在操纵？ https://substack.com/@stopthoseshots/note/c-199131475
Dr. Peter Hotez was caught red handed… gaslighting families that have had pediatricians kick them out of their practices or worse, had protective services called on them for wanting to opt out of the CDC recommendations. peterhotez says that in Dr’s offices, “there was never coercion.” We know this has been happening for years, but even CBS news reported this was happening as far back as 2012… a survey by the American Journal of Preventative Medicine showed that 25% of pediatricians have fired patients for refusing vaccines. Sounds like coercion to me… who’s gaslighting now?
彼得·霍特兹（Peter Hotez）医生被当场抓获……煤气灯操纵下的家庭被儿科医生踢出诊所，甚至更糟糕的是，因为他们想要选择不接受疾病控制与预防中心（CDC）的建议，保护部门要求他们这样做。 彼得霍特兹说，在博士的办公室里，“从来不存在强迫行为。” 我们知道这种情况已经发生很多年了，但就连哥伦比亚广播公司的新闻也报道说这种情况早在 2012 年就发生过……《美国预防医学杂志》的一项调查显示，25% 的儿科医生因拒绝接种疫苗而解雇了患者。 对我来说听起来像是胁迫……现在是谁在操纵？ https://substack.com/@stopthoseshots/note/c-199131475
6
HANrongli
2026 Jan 13, 10:24pm
"Chemotherapy is a hoax perpetuated by Big Pharma to make money at the expense of people who suffer."
"The performance of chemotherapy is appalling, but it generates billions of dollars."
https://open.substack.com/pub/drwojakmd/p/insiders-admit-modern-medicine-is-a-fraud “化疗是大型制药公司为了赚钱而以牺牲患者利益为代价的骗局。”
“化疗的效果令人震惊，但它产生了数十亿美元。”
https://open.substack.com/pub/drwojakmd/p/insiders-admit-modern-medicine-is-a-fraud
"Chemotherapy is a hoax perpetuated by Big Pharma to make money at the expense of people who suffer."
"The performance of chemotherapy is appalling, but it generates billions of dollars."
https://open.substack.com/pub/drwojakmd/p/insiders-admit-modern-medicine-is-a-fraud “化疗是大型制药公司为了赚钱而以牺牲患者利益为代价的骗局。”
“化疗的效果令人震惊，但它产生了数十亿美元。”
https://open.substack.com/pub/drwojakmd/p/insiders-admit-modern-medicine-is-a-fraud
7
HANrongli
2026 Jan 13, 11:39pm
Pandemic: The Hidden Agenda Behind Covid 19.
WATCH NOW: 流行病：Covid 19 背后的隐藏议程。
立即观看： https://substack.com/@stopthoseshots/note/c-199132718
Pandemic: The Hidden Agenda Behind Covid 19.
WATCH NOW: 流行病：Covid 19 背后的隐藏议程。
立即观看： https://substack.com/@stopthoseshots/note/c-199132718
9
HANrongli
2026 Jan 14, 6:39am
💉🧂🐷🐂🐖🐑🐓🥩☣️🚮🏥💰
🚨Shocking Revelation from 5th Gen Cattle Rancher Braden Jensen: mRNA Vaccines Tested on Livestock!
They injected 525 hogs with a live mRNA vaccine. In just 21 days:
- 25 died outright
- 55 became anorexic & near death
- 20 suffered lameness
- 12 lost condition
- 25 more had near-death symptoms
That's 30% with severe issues! Autopsies even found vaccine remnants in the meat. As consumers, are we eating this? As producers, is this destroying our herds?
What do y'all think? How sinister is this?! Drop your thoughts, RT if this alarms you, and tag a friend! Let's spread awareness. Buy American, buy local! 🇺🇸 🚨来自第五代牧场主布雷登·詹森（Braden Jensen）的震惊揭露：mRNA疫苗在牲畜身上进行试验！
他们向525头猪注射了活性mRNA疫苗。仅仅21天后：
• 25头猪当场死亡
• 55头猪出现食欲不振、接近死亡
• 20头猪出现跛行
• 12头猪体况变差
• 另外25头猪出现接近死亡的症状
这意味着30%的猪出现了严重问题！尸检甚至发现了疫苗残留在肉中。作为消费者，我们在吃这些吗？作为生产者，这是否在摧毁我们的牲畜？
你们怎么看？这有多可怕？！留下你的想法，如果你感到震惊，请转发并标记朋友！让我们提高警觉，支持本地购买，支持美国生产！🇺🇸 https://substack.com/@stopthoseshots/note/c-199603516
🚨Shocking Revelation from 5th Gen Cattle Rancher Braden Jensen: mRNA Vaccines Tested on Livestock!
They injected 525 hogs with a live mRNA vaccine. In just 21 days:
- 25 died outright
- 55 became anorexic & near death
- 20 suffered lameness
- 12 lost condition
- 25 more had near-death symptoms
That's 30% with severe issues! Autopsies even found vaccine remnants in the meat. As consumers, are we eating this? As producers, is this destroying our herds?
What do y'all think? How sinister is this?! Drop your thoughts, RT if this alarms you, and tag a friend! Let's spread awareness. Buy American, buy local! 🇺🇸 🚨来自第五代牧场主布雷登·詹森（Braden Jensen）的震惊揭露：mRNA疫苗在牲畜身上进行试验！
他们向525头猪注射了活性mRNA疫苗。仅仅21天后：
• 25头猪当场死亡
• 55头猪出现食欲不振、接近死亡
• 20头猪出现跛行
• 12头猪体况变差
• 另外25头猪出现接近死亡的症状
这意味着30%的猪出现了严重问题！尸检甚至发现了疫苗残留在肉中。作为消费者，我们在吃这些吗？作为生产者，这是否在摧毁我们的牲畜？
你们怎么看？这有多可怕？！留下你的想法，如果你感到震惊，请转发并标记朋友！让我们提高警觉，支持本地购买，支持美国生产！🇺🇸 https://substack.com/@stopthoseshots/note/c-199603516
10
HANrongli
2026 Jan 14, 6:43am
🙏🕊️🕯️🌲⛰️😭
Reflecting on Scott Adams' viral bombshell: "The anti-vaxxers clearly won, you're the winners"? Dropped three years ago, it hits deeper now after his passing from prostate cancer. Deeply grateful for his courage in speaking out. RIP 回顾斯科特·亚当斯（Scott Adams）那句引起轰动的爆炸性言论：“反疫苗者显然赢了，你们是赢家”，这句话三年前说出，现在在他因前列腺癌去世后，听起来更加深刻。非常感激他敢于发声的勇气。愿他安息。 https://substack.com/@stopthoseshots/note/c-199590644
Reflecting on Scott Adams' viral bombshell: "The anti-vaxxers clearly won, you're the winners"? Dropped three years ago, it hits deeper now after his passing from prostate cancer. Deeply grateful for his courage in speaking out. RIP 回顾斯科特·亚当斯（Scott Adams）那句引起轰动的爆炸性言论：“反疫苗者显然赢了，你们是赢家”，这句话三年前说出，现在在他因前列腺癌去世后，听起来更加深刻。非常感激他敢于发声的勇气。愿他安息。 https://substack.com/@stopthoseshots/note/c-199590644
11
HANrongli
2026 Jan 14, 6:47am
‘When my kids get a fever, I give them Magnesium. Magnesium regulates core body temperate through the hypothalamus’.- Bryan Ardis
“当我的孩子发烧时，我会给他们补充镁。 镁通过下丘脑调节核心体温。- Bryan Ardis https://substack.com/@phrygiofphrygia/note/c-198907737
‘When my kids get a fever, I give them Magnesium. Magnesium regulates core body temperate through the hypothalamus’.- Bryan Ardis
“当我的孩子发烧时，我会给他们补充镁。 镁通过下丘脑调节核心体温。- Bryan Ardis https://substack.com/@phrygiofphrygia/note/c-198907737
记者超计量服用维生素D OMEGA-3 三个月日服16粒 健康指数明显提高
Journalist Overdoses on Vitamin D OMEGA-3: Taking 16 Capsules Daily for Three Months, Health Index Significantly Improves
Journalist’s Review: Given the importance of vitamin D (OMEGA-3) in the expression of human neuroendothelial cells and other related processes, in an effort to counter the misinformation about side effects, the journalist tried taking 8 capsules of vitamin D in the morning and 8 in the evening (a total of 16 capsules per day). Additionally, the journalist also took various other vitamins, including K2, C, B, zinc, magnesium, and others, for three months. No adverse effects were observed, and the health index showed a significant improvement. The rumors have been debunked on their own! / France: Free Health and Human Rights Reporter: Han Rongli
记者综述：鉴于维生素D（OMEGA-3）对人体神经内皮细胞等系列表达的重要性，为抵御副作用谎言，记者尝试了每天早8粒、晚8粒，（每天服用16粒维生素D）同时还服用维生素K2、C、B、锌、镁、…等各种维生素，三个月，没发现任何不适，健康指数明显提升。谣言不攻自破！/ 法国：自由健康人权记者：韩荣利
This is consistent with a study almost a decade ago. That study was done in colon cancer and with a higher dosage, although still fairly small. It found a survival benefit to the vitamin D supplementation as well.
There are numerous Vitamin D studies that show no survival benefit, but they all used ridiculously low dosages. Some do not even reach the standard INFANT dose, much less an adult dose.
To date, no randomized controlled trial I have seen has used a large dose of Vitamin D, though. This trial was quite small, and most of a the patients were still Vitamin D deficient. What would happen with larger doses? What if the patients were well into the healthy level of serum Vitamin D? I would really like to see that. 这与大约十年前的一项研究是一致的。 该研究是针对结肠癌进行的，剂量较高，但剂量仍然相当小。 研究发现补充维生素 D 对生存也有好处。
有大量维生素 D 研究表明维生素 D 对生存没有益处，但它们的剂量都低得离谱。 有些甚至达不到标准婴儿剂量，更不用说成人剂量了。
不过，迄今为止，我还没有见过使用大剂量维生素 D 的随机对照试验。 这项试验规模相当小，大多数患者仍然缺乏维生素 D。 如果剂量更大会发生什么？ 如果患者的血清维生素 D 处于健康水平怎么办？ 我真的很想看到这一点。 https://substack.com/@concerningcancer/note/c-198132826
Vitamin D during neoadjuvant chemo: can you improve your odds of a strong response?
In a randomized trial, 2,000 IU/day of vitamin D increased the pathologic complete response rate versus placebo.
Ask to check your 25(OH)D level and correct deficiency. 新辅助化疗期间的维生素 D：可以提高强烈反应的几率吗？
在一项随机试验中，与安慰剂相比，每天 2,000 IU 的维生素 D 可以提高病理完全缓解率。
要求检查您的 25(OH)D 水平并纠正缺陷。
維生素D補充劑改善接受新輔助化療的乳腺癌患者的病理完全反應：一項隨機臨床試驗
Michelle Sako Omodei等人。 營養癌。 2025.
Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial
Michelle Sako Omodei et al. Nutr Cancer.2025.
https://pubmed.ncbi.nlm.nih.gov/40098326/
Abstract
This study aimed to evaluate the effect of vitamin D (VD) supplementation on the pathological complete response (pCR) rate in women with breast cancer (BC) undergoing neoadjuvant chemotherapy (NCT). A randomized clinical trial was conducted with 80 women aged ≥45years with BC who were eligible for NCT. Women were randomized into two groups: VD group, daily supplementation with 2,000IU of cholecalciferol (n = 40) or placebo (n = 40), for 6 months. The primary outcome measure was the pCR rate. Serum 25-hydroxyvitamin-D [25(OH)D] levels were measured after BC diagnosis and the end of NCT. Of the 80 randomized women, 75 completed the NCT and underwent surgery. Baseline 25(OH)D values indicated hypovitaminosis D in both groups (VD: 19.6 ± 5.8 ng/mL and placebo: 21 ± 7.9 ng/mL, p = 0.33). After 6 months, 25(OH)D levels increased in the VD group compared to the placebo group (28 ± 8.7 vs. 20.2 ± 6.1 ng/mL, p = 0.03). The pCR rate was higher in women supplemented with VD when compared than the placebo (43% vs. 24%, p = 0.04). Adjusted logistic regression showed that women with 25(OH)D levels ≥20ng/mL were more likely to achieve pCR (OR3.65, 95%CI 1.09-12.8, p = 0.04). Women with BC undergoing NCT who received supplementation with 2,000IU of VD were more likely to achieve a pathological complete response than women in the placebo group.
Trial registration: Ensaiosclinicos.gov.br, identifier RBR-10k4gqdg.
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抽象的
這項研究旨在評估維生素D（VD）補充劑對接受新輔助化療（NCT）的乳腺癌（BC）婦女病理完全反應（pCR）率的影響。 對80名年齡≥45歲的BC女性進行了隨機臨床試驗，她們符合NCT的條件。女性被隨機分為兩組：VD組，每天補充2000IU的膽鈣化醇（n = 40）或安慰劑（n = 40），持續6個月。 主要結果衡量標準是pCR率。 在BC診斷和NCT結束後測量了血清25-羥基維生素D [25(OH)D]水準。在80名隨機女性中，75人完成了NCT並接受了手術。 基線25（OH）D值表明兩組維生素D低（VD：19.6 ± 5.8 ng/mL和安慰劑：21 ± 7.9 ng/mL，p = 0.33）。 6個月後，與安慰劑組相比，VD組的25（OH）D水準增加（28±8.7與20.2±6.1納克/毫升，p=0.03）。 與安慰劑相比，補充VD的女性的pCR率更高（43%與24%，p = 0.04）。 調整後的邏輯迴歸表明，25（OH）D水準≥20ng/mL的女性更有可能達到pCR（OR3.65，95%CI 1.09-12.8，p = 0.04）。 與安慰劑組的婦女相比，接受2000IU VD補充的BC女性更有可能達到病理完全反應。
試驗註冊：Ensaiosclinicos.gov.br，識別符號RBR-10k4gqdg。
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