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研究：維生素C+

葡萄籽提取物

表現優於

減少腫瘤的化療

老鼠

在一項頭對頭的臨床前研究中，自然組合將癌症腫瘤體積減少了76.61%，超過了「紅魔鬼」多索黴素（68.82%）。

尼古拉斯·赫爾舍，英里/小時

今天01:08

STUDY: Vitamin C +
Grape Seed Extract
Outperforms
Chemotherapy for Tumor Reduction in
Mice
Natural combo cut cancerous tumor volume by 76.61%, surpassing the "red devil" doxorubicin (68.82%) in a head-to-head preclinical study.
NICOLAS HULSCHER, MPH
TODAY AT 01:08

GSE：（葡萄柚籽萃取）+ 維生素C的組合对于癌症的医学论文
GSE + Vitamin C combination in cancer medical research papers.

https://open.substack.com/pub/petermcculloughmd/p/study-vitamin-c-grape-seed-extract

by Nicolas Hulscher, MPH
A recent preclinical cancer study produced a striking result: in a mouse solid tumor model (Ehrlich carcinoma), a combination of Grape Seed Extract (GSE) + Vitamin C reduced tumor volume more than chemotherapy. Researchers compared multiple treatment arms—including doxorubicin (DOX, nicknamed the “red devil”) as the chemo comparator—and found that the GSE + Vitamin C group showed the greatest mean tumor volume reduction, outperforming DOX in this experiment.

Greater tumor reduction than chemotherapy

In other words, within this model, the GSE + Vitamin C combination produced the greatest mean tumor shrinkage, exceeding the reduction seen with doxorubicin chemotherapy.

GSE + Vitamin C rewired tumor biology and flipped the immune microenvironment
Beyond simply reducing tumor size, the GSE + Vitamin C combination produced marker changes consistent with a real mechanistic anti-cancer effect—suppressing tumor growth signals while activating tumor cell death and immune pressure:

Taken together, these findings suggest the combo wasn’t just slowing growth—it was pushing tumors toward cell death while making the tumor environment less immune-protected and more vulnerable to immune attack.

Conclusion
This is a compelling head-to-head preclinical comparison—but it remains a mouse study. Still, the effect size, the chemo comparator, and the immune remodeling signals make it a result worth serious attention and follow-up.
In this mouse tumor model, GSE + Vitamin C outperformed the “red devil” chemotherapy, achieving 76.61% vs. 68.82% mean tumor volume reduction, while also showing tumor marker and immune-environment changes consistent with true anti-cancer activity. And this isn’t surprising—a large body of research has documented anti-cancer mechanisms of vitamin C across multiple tumor systems, especially through oxidative stress–mediated tumor injury and immune support.

作者：Nicolas Hulscher，MPH

最近的一項臨床前癌症研究產生了一個驚人的結果：在小鼠實體腫瘤模型（Ehrlich癌）中，葡萄籽提取物（GSE）+維生素C的組合比化療減少了更多的腫瘤體積。 研究人員比較了多個治療組——包括多黴素（DOX，綽號「紅魔鬼」）作為化療比較劑——發現GSE + 維生素C組的平均腫瘤體積減少最大，在這項實驗中表現優於DOX。

比化療更大的腫瘤減少

換句話說，在這個模型中，GSE + 維生素C組合產生了最大的平均腫瘤收縮，超過了多黴素化療的減少。

GSE + 維生素C重新連線了腫瘤生物學，並顛覆了免疫微環境

除了簡單地減少腫瘤大小外，GSE + 維生素C組合還產生了與真正的機械抗癌作用一致的標記變化——抑制腫瘤生長訊號，同時啟動腫瘤細胞死亡和免疫壓力：

綜上所述，這些發現表明，這種組合不僅減緩了生長，而且將腫瘤推向細胞死亡，同時使腫瘤環境的免疫保護較差，更容易受到免疫攻擊。

結論

這是一個令人信服的頭對頭臨床前比較——但它仍然是一項小鼠研究。 儘管如此，效果大小、化療比較器和免疫重塑訊號使其成為值得認真關注和跟進的結果。

在這個小鼠腫瘤模型中，GSE +維生素C優於「紅魔鬼」化療，實現了76.61%與68.82%的平均腫瘤體積減少，同時也顯示出與真正的抗癌活性一致的腫瘤標誌物和免疫環境變化。 這並不奇怪——大量研究記錄了維生素C在多個腫瘤系統中的抗癌機制，特別是透過氧化應激介導的腫瘤損傷和免疫支援。
……