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1
Al_Sharpton_for_President
2023 Jan 3, 1:47pm
Al_Sharpton_for_President
2023 Jan 3, 1:47pm
Among the four immunoglobulin G (IgG) subclasses, IgG4 is the least represented in serum of a healthy human and it is considered an "odd" antibody. The IgG4 antibody has unique structural features that affect its biological function.
Altogether, these characteristics support anti-inflammatory roles of IgG4 leading to immune tolerance. Under conditions of chronic antigenic stimulation and Th2-type inflammation, both tissue and serum IgG4 levels are increased.
This review seeks to highlight how in allergen immunotherapy IgG4 can confer a protective role as a "blocking" antibody and safeguard from subsequent allergen exposure, while IgG4 can confer immunomodulatory functions to support malignancy.
While Th2 conditions drive polarization of macrophages to the M2a subtype, chronic antigen stimulation drives B cell class switching to IgG4 to further support phenotypical macrophage changes towards an M2b-like state.
M2b-like macrophages can secrete chemokine (C-C motif) ligand 1 (CCL1) and interleukin-10 (IL-10) to support regulatory cell recruitment and to further shape a tolerogenic microenvironment. Thereby, IgG4 have a Janus-faced role, favorable in allergy but detrimental in cancer.
https://pubmed.ncbi.nlm.nih.gov/32708690/
Altogether, these characteristics support anti-inflammatory roles of IgG4 leading to immune tolerance. Under conditions of chronic antigenic stimulation and Th2-type inflammation, both tissue and serum IgG4 levels are increased.
This review seeks to highlight how in allergen immunotherapy IgG4 can confer a protective role as a "blocking" antibody and safeguard from subsequent allergen exposure, while IgG4 can confer immunomodulatory functions to support malignancy.
While Th2 conditions drive polarization of macrophages to the M2a subtype, chronic antigen stimulation drives B cell class switching to IgG4 to further support phenotypical macrophage changes towards an M2b-like state.
M2b-like macrophages can secrete chemokine (C-C motif) ligand 1 (CCL1) and interleukin-10 (IL-10) to support regulatory cell recruitment and to further shape a tolerogenic microenvironment. Thereby, IgG4 have a Janus-faced role, favorable in allergy but detrimental in cancer.
https://pubmed.ncbi.nlm.nih.gov/32708690/
2
GNL
2023 Jan 3, 2:53pm
GNL
2023 Jan 3, 2:53pm
Endless minutiae. I saw "IgG4" as a term a few days ago and now I'm seeing it everywhere.
3
richwicks
2023 Jan 3, 3:07pm
richwicks
2023 Jan 3, 3:07pm
GNL says
Basically the hypothesis is that IgG3 will actively go and remove a pathogen from your body, but IgG4 won't. From what (little) I have HEARD, IgG4 is activated to suppress your immune response to a pathogen, like hayfever and pollen. Basically, it tells your body "yeah, false alarm" and attaches to the pathogen but it's not actively removed from your system. So it reduces inflammation (which is apparently what people go through that have allergies) or prevents it entirely.
Well, this isn't a problem for pathogens that don't reproduce in your body, but a virus will reproduce - so, the virus is free to reproduce, the IgG4 says it's OK, and the IgG3 doesn't try to remove it from the body - so you get "long covid" when you get covid. You end up with an eternal infection - well not eternal, it will eventually kill you.
That's what I've heard, basically, in a nutshell.
Endless minutiae. I saw "IgG4" as a term a few days ago and now I'm seeing it everywhere.
Basically the hypothesis is that IgG3 will actively go and remove a pathogen from your body, but IgG4 won't. From what (little) I have HEARD, IgG4 is activated to suppress your immune response to a pathogen, like hayfever and pollen. Basically, it tells your body "yeah, false alarm" and attaches to the pathogen but it's not actively removed from your system. So it reduces inflammation (which is apparently what people go through that have allergies) or prevents it entirely.
Well, this isn't a problem for pathogens that don't reproduce in your body, but a virus will reproduce - so, the virus is free to reproduce, the IgG4 says it's OK, and the IgG3 doesn't try to remove it from the body - so you get "long covid" when you get covid. You end up with an eternal infection - well not eternal, it will eventually kill you.
That's what I've heard, basically, in a nutshell.
4
EBGuy
2023 Jan 3, 3:36pm
Time machine to one year ago...
The European Union’s drug regulator is warning that too many doses of COVID-19 vaccines could eventually weaken the body’s immune system, rendering the extra shots ineffective.
The European Union’s drug regulator is warning that too many doses of COVID-19 vaccines could eventually weaken the body’s immune system, rendering the extra shots ineffective.
5
GNL
2023 Jan 3, 3:39pm
GNL
2023 Jan 3, 3:39pm
EBGuy says
"Too many doses...". So, the original jab is not a problem. Billions WILL NOT DIE.
Time machine to one year ago...
The European Union’s drug regulator is warning that too many doses of COVID-19 vaccines could eventually weaken the body’s immune system, rendering the extra shots ineffective.
"Too many doses...". So, the original jab is not a problem. Billions WILL NOT DIE.
6
Al_Sharpton_for_President
2023 Jan 3, 3:45pm
Al_Sharpton_for_President
2023 Jan 3, 3:45pm
GNL says
Not in the MSM.
Dehninger covered it on Dec 26 2002.
Here is the link he reported on:
https://www.rintrah.nl/the-trainwreck-of-all-trainwrecks-billions-of-people-stuck-with-a-broken-immune-response/
and now I'm seeing it everywhere
Not in the MSM.
Dehninger covered it on Dec 26 2002.
Here is the link he reported on:
https://www.rintrah.nl/the-trainwreck-of-all-trainwrecks-billions-of-people-stuck-with-a-broken-immune-response/
7
richwicks
2023 Jan 3, 3:48pm
richwicks
2023 Jan 3, 3:48pm
GNL says
It could be cumulative damage.
It's possible that one jab basically permanently damages your immune system because your body permanently makes the spike protein. If this happens, your body will have to treat the spike protein which is the toxin, as something to ignore (possibly). IF your body produces this spike protein for the rest of your life, and the cells that produce it have incorporated into their DNA and replicate as they replace themselves, what replaces them will also produce the spike protein.
So, IF some cells permanently encode the the genetic code to make the spike protein into their DNA, and IF these cells are never destroyed by your immune system, and IF the spike protein is guaranteed to kill you eventually - yeah, everybody that took it is dead. The more shots you took, likely the quicker you should die.
But there's a crapload of IFs in there, aren't there?
Maybe everybody that has taken at least one shot is GUARANTEED to die from the shot like - in like 1000 years, if something else doesn't kill them first..
There's no sense in worrying about it now, you can't do anything about it. If people who are all boostered up who are 20-35 stop dropping, then you know something is up but we're going to find out anyhow, so why worry about it until you know something? And EVEN if you know, you can't do anything about it, so why worry?
EBGuy says
Time machine to one year ago...
The European Union’s drug regulator is warning that too many doses of COVID-19 vaccines could eventually weaken the body’s immune system, rendering the extra shots ineffective.
"Too many doses...". So, the original jab is not a problem. Billions WILL NOT DIE.
It could be cumulative damage.
It's possible that one jab basically permanently damages your immune system because your body permanently makes the spike protein. If this happens, your body will have to treat the spike protein which is the toxin, as something to ignore (possibly). IF your body produces this spike protein for the rest of your life, and the cells that produce it have incorporated into their DNA and replicate as they replace themselves, what replaces them will also produce the spike protein.
So, IF some cells permanently encode the the genetic code to make the spike protein into their DNA, and IF these cells are never destroyed by your immune system, and IF the spike protein is guaranteed to kill you eventually - yeah, everybody that took it is dead. The more shots you took, likely the quicker you should die.
But there's a crapload of IFs in there, aren't there?
Maybe everybody that has taken at least one shot is GUARANTEED to die from the shot like - in like 1000 years, if something else doesn't kill them first..
There's no sense in worrying about it now, you can't do anything about it. If people who are all boostered up who are 20-35 stop dropping, then you know something is up but we're going to find out anyhow, so why worry about it until you know something? And EVEN if you know, you can't do anything about it, so why worry?
8
EBGuy
2023 Jan 3, 3:54pm
GNL says
We're a two and done family, so crossing my fingers that is the case. I really vacillated on whether to get a booster before visiting my elderly parents this Xmas. At this point, I'm glad I didn't succumb.
So, the original jab is not a problem.
We're a two and done family, so crossing my fingers that is the case. I really vacillated on whether to get a booster before visiting my elderly parents this Xmas. At this point, I'm glad I didn't succumb.
9
EBGuy
2023 Jan 3, 4:05pm
Al_Sharpton_for_President says
Yeah, the original paper came out on December 22. The DarkHorse podcast had a good breakdown a couple of days ago.
Bret and Heather 155th DarkHorse Podcast Livestream: Unnatural Anti-Immunity
https://youtu.be/1c0Gfk-juC0?t=3526
Not in the MSM.
Yeah, the original paper came out on December 22. The DarkHorse podcast had a good breakdown a couple of days ago.
Bret and Heather 155th DarkHorse Podcast Livestream: Unnatural Anti-Immunity
https://youtu.be/1c0Gfk-juC0?t=3526
IgG4 is the least common of the 4 subtypes of IgG. Its function likely varies with the context; in allergic disease, it is thought to have an immune-inhibitory role in preventing anaphylactic reactions to allergens. It has also been reported to have a role in autoimmunity and malignancy, but its function in these contexts is less well established. IgG4-RD has a wide range of manifestations that are unified by their histopathologic findings and response to treatment.
From SCIENCE Immunology:
Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors... The IgG4 subclass does not prevail after repeated vaccination with tetanus toxoid or respiratory syncytial virus infection.