patrick.net

Are you peeps aware of the degree of genetic disease in countries that breed like that? Not to mention the inbreeding involved.

That paper has zero to do with feminism. I sat right next to the guy when he was finishing it off. Had not a fuck in the world to do with any political shit. Just plain GOOD science. I know we're lacking that these days but it does still exist.

Comment on the paper anyone?

Reality says

I can see a very good reason why correlation between fathers being physicists, engineers and scientists vs. autism can lead to observed "old-dad" correlation when tabulated by a feminist with an agenda (blaming men)

re: ^^

Countries that breed like what? Older men and younger women? Is there some association with genetic disease?

Re the paper:

The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from de novo mutations in variant-intolerant genes. We hypothesize that rare inherited structural variants in cis-regulatory elements (CRE-SVs) of these genes also contribute to ASD. We investigated this by assessing evidence for natural selection and transmission distortion of CRE-SVs in whole genomes of 9,274 subjects from 2,600 families affected by ASD. In a discovery cohort of 829 families, structural variants were depleted within promoters and UTRs, and paternally-inherited CRE-SVs were preferentially transmitted to affected offspring and not to their unaffected siblings. The association of paternal CRE-SVs was replicated in an independent sample of 1,771 families. Our results suggest that rare inherited non-coding variants predispose children to ASD, with differing contributions from each parent.

What's "cis" about cis-regulatory elements?And is he saying that these "non-coding" variants don't make any proteins, but instead have some epi-genetic effect?

India, the middle east, the US long ago; countries that inbreed.

Also, older guys shoot blanks most of the time anyway so it's not like they were having tons of kids. The paper also mentions the combo of women (also older) and older men in this phenom.

Thanks for not grouping me in with feminists I hate the fucks and great question!

So MOST of what scientists have focused on over the past 11 years since genome reading became cheap are the coding regions for proteins. The genes basically. People argue that's only 7-15% of the genome but the point is it's very small. The rest used to be called the desert. Where in fact, since the olden days a few years ago we've started to realize there are all sorts of control mechanisms we don't know much about yet in these regions. Surprise surprise lol...

Honestly most of what has been accomplished since the genome project was 'finished' in 2003 has been quite underwhelming to say the least. More so when you consider how much money has been spent on it.

We can do research like this though for now and it will get better. You can sort of think of it as epigenetics but it's lower level and harder to get at. We can do methylation (epigenetic) dna sequencing better than SVs at the moment I think. It's sort of like just reading a new letter vs. AGCT <- some get methylated and are then 'different' and can be read differently. Those are the epigenetic switches.

just_passing_through says

Also, older guys shoot blanks most of the time anyway so it's not like they were having tons of kids. The paper also mentions the combo of women (also older) and older men in this phenom.

It's probably older eggs. Since older women-younger men pairs are more rare, it'll be harder to find comparable numbers, but I bet it's ancient eggs that is more important than the age of the sperm.

Because we live in a time of RONN Narrative Defense from the Clerisy, which wants females to delay childbirth, this line of research is unlikely to be funded, and if it is, dismissed or torn apart.

just_passing_through says

Are you peeps aware of the degree of genetic disease in countries that breed like that? Not to mention the inbreeding involved.

Bred like what? What does large male-female age-gap in mating have to do with inbreeding? Most historical (and current in some countries) inbreeding involve first-cousins that grow up together therefore relatively close in age. BTW, before widespread social safety-net and medical intervention, inbreeding likely helped populations get rid of genetic diseases (as two copies of the detrimental recessive gene would kill the person and thereby taking the gene out of the population) and promote desirable traits (including intelligence itself). Genetically speaking, Jews are/were among the most inbred population (at least in Europe) and that did not stop Jews from having a 15% IQ advantage over the average of the rest of Europeans, but likely contributed to higher IQ (the lower IQ ones also produced by inbreeding got wiped out in pogroms each generation or otherwise prevented from breeding by girls).

Refer to my earlier comment regarding why a simple tabulation of father age would be influenced by coincidental correlation with fathers that are wealthy enough to have younger and still reproductive wives in the fathers' own advanced age (and still willing to be reproducing, i.e. correlation with physical-science/engineering types) . . . not to mention older fathers statistically also correlate to older mothers.

In fact, it is quite possible that genes that result in high intelligence may well be related to mild autism and anti-social behavioral tendencies . . . just look at all the average pleasant sheep getting jabs as told, whereas both the anti-jab crowd (those who see a problem on their own) and the scamsters that came up with the jab to begin with (not the silly followers) are often highly intelligent.

MisdemeanorRebellionNoCoupForYou says

but I bet it's ancient eggs that is more important than the age of the sperm.

There is actually support for that in the paper:

We propose three possible mechanisms to explain the observed paternal-origin effect of CRE-SVs, the first is a “bilineal two-hit model”, in which inherited risk is attributable to a combination of two risk variants: a maternally-inherited coding variant of large effect and a paternally-inherited CRE variant of moderate effect.

Patrick says

"cis" about cis-regulatory elements?

Cis and trans have long been chemistry terms, that were relatively recently adopted by LGBTQ in the context of human sexuality and identity. They are latin roots that basically mean "on the same side of" and "on the opposite side of." Trans fats are a completely non gender related example you've heard of.

Automan Empire says

Cis and trans have long been chemistry terms, that were relatively recently adopted by LGBTQ in the context of human sexuality and identity. They are latin roots that basically mean "on the same side of" and "on the opposite side of." Trans fats are a completely non gender related example you've heard of.

"Science Washing" Socio-Political Opinions.

Economists do this as well.

MisdemeanorRebellionNoCoupForYou says

"Science Washing" Socio-Political Opinions.

I see a sensible and intuitive analogy with the terms. Thematic apperception at play on your part, perhaps.

Automan Empire says

I see a sensible and intuitive analogy with the terms. Thematic apperception at play on your part, perhaps.

There is no objective metric to "Gender Fluidity". It is entirely philosophically constructed and subjectively answered questionnaires.

We don't validate Paranoid Schizos or Anorexics' claims, why do we validate Paraphiliac claims?

MisdemeanorRebellionNoCoupForYou says

There is no objective metric to "Gender Fluidity"

That doesn't change the intuitive utility of using the terms cis- and trans- when discussing the topic of nonconventional sexualities.

I don't think anyone cares about your wishes and efforts to gatekeep the usage of these terms by groups for whom you carry a preexisting dislike.

https://www.scribd.com/doc/220807175/160-Research-Papers-Supporting-the-Vaccine-Autism-Link

Original Title:160 Research Papers Supporting the Vaccine/Autism Link
Description:Media reports have claimed that there is no scientific evidence supporting the link between vaccines and autism. Here we provide for the reader research that demonstrates links between vaccines and autism, and the mechanisms by which vaccines can cause autism.

This simply says We The People do not trust the vaccines.



https://twitter.com/NBCNews/status/1722713736954204169

https://twitter.com/wolsned/status/1725058928415764975

The vast, vast majority of childhood vaccines are for bacterial diseases that only impact in very poor hygiene/sanitation situations.

They're all very rare in the presence of clean running water and trash collection. There's simply no reason to get them unless you expect children to be exposed to overcrowded, primitive conditions for long periods of time.

Diphtheria is a great example. Aside from wartorn Europe and an overcrowded Imperial Japanese ship and barracks in 1942-43 (when they were literally stacked like cordwood inside barracks meant for a fraction of the people; and had travelled on the inside of cargo ships - not passenger vessels - in worse conditions), outbreaks are unheard of. Interestingly, there were deaths from improperly made diptheria vaccines in Japan after the war.

The_Deplorable says

https://twitter.com/wolsned/status/1725058928415764975

Main stream media strongly against this idea, so its probably true.

The_Deplorable says

.



Caregivers?
They used to be called parents.

Onvacation says

Caregivers?
They used to be called parents.

Yes, and saying "religious or other personal concerns" paints the caretakers as unscientific rather that the genuine reason of the vaccines being given too early making them dangerous.

https://palexander.substack.com/p/cdc-said-what-those-inept-corrupted

So, Trump flips burgers and works the fries one day at McDonald’s then low and behold, now CDC says McDonald’s has problem? Something stinks.

Now no doubt, these food places need to be policed routinely for any breaches that could hurt us. But this seems political to me, and I am investigating to learn more.

In my opinion, CDC is a waste of time fraud employees, inept incompetent, academically sloppy, intellectually lazy, specious officials.

Same bullshit fraud CDC did when I was at HHS during COVID, these fuckers, these demons at CDC and FDA would produce MMWR reports by the fucking hour, thousands of inept overpaid low-life employees just sitting around waiting to get orders to gin up a report…to damage Trump…report after report that Redfield walked around wringing his hand ‘oh I can’t do anything about it’ while they fucked Trump…if he Trump said ‘this’, they would write a report saying opposite to hurt him. They reported to him Redfield, yet he, Redfield could do nothing about it as CDC and FDA and NIH and HHS fucked Trump for one full year and stole the election.

Same fraud they did in COVID and now you see how they do the hit pieces at CDC…Trump visits McDonald’s, then CDC writes a hit piece on the place.

There is NOTHING CDC ever says today that is true, now, too corrupted and was so for decades, Trump must burn CDC down, take it to the studs, close 90% and relocate CDC to Alcatraz. Fire 5,000 at CDC top down on day one. Obama knew how to handle CDC shutting down their fraud H1N1 2009 swine flu fraud.

https://palexander.substack.com/p/cdc-let-me-share-something-from-on

CDC: Let me share something from on the inside while at HHS & privy to high-level talks, POTUS Trump was moving to relocate CDC from Atlanta & he was tabling firing 1000 CDC staff top down in 2nd term had Trump been re-elected, we were going to remove CDC HQ from Atlanta and fire 1000 instantly, if he could ONLY reassign to other jobs & could not legally fire, he was going to move them