patrick.net

Patrick says

This all strikes me as potentially one of the best buying opportunities ever, if you can time it right.

Don't time it, just buy. If you're inclined to research individual stocks, go ahead, but index funds would do just fine. This is going to go down as one of the biggest stock market overreactions in history.

Call me out in 6 months if I'm wrong, but this is so massively overblown and I'm usually not a stock market cheerleader.

UGH, even when called out for being idiots, they double down.

Media is full of idiots, thank goodness they're over.

Sri Lanka, Azerbaijan, Egypt, Mexico, Estonia, New Zealand, Belarus, Denmark, Belgium, Netherlands, Iceland, Norway, Nigeria, Ireland, Georgia, Lithuania, Nepal, Canada....

NoCoupForYou says

UGH, even when called out for being idiots, they double down.

Media is full of idiots, thank goodness they're over.

I'm pretty sure new antibiotic development is not "badly underfunded"

I jumped in with both feet today.

HEYYOU says

Some things are worth repeating.

Agent Smith:
I'd like to share a revelation that I've had during my time here.It came to me when I tried to classify your species. I've realized that you are not actually mammals.Every mammal on this planet instinctively develops a natural equilibrium with the surrounding environment. But you humans do not.You move to an area and you multiply and multiply until every natural resource is consumed and the only way you can survive is to spread to another area.You move to an area and you multiply and multiply until every natural resource is consumed and the only way you can survive is to spread to another area.Human beings are a disease, a cancer of this planet. You are a plague.

As an aside;,"Your children aren't special!" & neither are your parents' children special!

That's pretty much the liberal set of beliefs today in a nutshell. They hate human race. In all honesty I think they should prove their point by killing themselves.

theoakman says

I'm pretty sure new antibiotic development is not "badly underfunded"

It is, but that has nothing to do with government. Pharma has too small profits on something that cures you in 2 weeks so they do not invest in antibiotics. Furthermore, idiots who stop taking prescribed antibiotics early, and meat industry who pumps animals full of antibiotics create bacteria that are resistant to particular antibiotic, and so new ones have to be developed quickly.

rd6B says

Pharma has too small profits on something that cures you in 2 weeks so they do not invest in antibiotics.

Myth.

They don't invest in that class because sales of new antibiotics are restricted by the government.

rd6B says

It is, but that has nothing to do with government. Pharma has too small profits on something that cures you in 2 weeks so they do not invest in antibiotics.

Yeah their incentives are to let you die unless they can put you on life long treatment, like in the AIDS case, that will provide them a rent.

There's nothing the government can do either. It's not their job to interfere with the market.

just_dregalicious says

They don't invest in that class because sales of new antibiotics are restricted by the government.

Yes, government imposed safety tests are known to be too drastic. No one ever dies from a FDA approved drug!

By the way. I didn't pull that out of my ass. I was hanging out with our CEO (pharmacia corp) in 2000 and he flat out told me that. We aren't going to invest in something we can't sell.

Government's expected us to keep it tucked away for emergencies.

... makes sense to me...

Government's should then fund the research. That would fill the gap.

I think antibiotics will be replaced by Eastern Euro tech: phages

just_dregalicious says

rd6B says

Pharma has too small profits on something that cures you in 2 weeks so they do not invest in antibiotics.

Myth.

They don't invest in that class because sales of new antibiotics are restricted by the government.

Don't know for sure, this is second-hand knowledge for me. A student of mine who works in pharma advanced this idea, and my PhD advisor with connections in pharma was saying that as well.
One could also think that pharma executives will try to blame gubbermint for their companies not looking well.

I always hear conspiracy theories about them not wanting to cure cancer as well. As if it's a single disease.

Total crock of shit.

It's just hard as fuck to solve. We used to just name them by body part. Only very recently are we starting to understand their many molecular signatures.

rd6B says

student of mine who works in pharma advanced this idea, and my PhD advisor with connections in pharma was saying that as well.

I like academics but most don't know shit about industry and many have a chip on their shoulder about it.

In over 25 years at over a dozen companies I have never once encountered such a situation. Quite the opposite in fact. Everyone wants to be the person or on the team who saves lives and becomes famous and furthers their incredibly difficult careers.

Primarily by way of a cure for X disease. In the short run turning it into a chronic yet manageable condition is second only due to the difficulty of finding a cure. Better diagnostics a third.

The implication of these conspiracy theories is that myself and my peers would actually work for an outfit like that is ludicrous.

The rumor mills at these companies are wide open. We'd know...

I'll concede that sometimes man bites dog but that is not the rule.

just_dregalicious says

conspiracy theories about them not wanting to cure cancer as well

That one I have not heard.

Go look at the conversations under stock tickers.

We do compete against each other brutally though. For example 16 years ago a small biotech named Amylin discovered a diabetes drug from Gila monster saliva. An incretin mimetic.

They made a deal with big pharma Eli-Lilly (diabetes company) to do the marketing.

Lilly didn't market for shit and started their own secret incretin mimetic program instead. Total scandal and I'm leaving a lot out.

That sort of crap happens all the time sadly.

In the end Amylin was bought out for pennies on the dollar for what they should have been worth.

just_dregalicious says

Go look at the conversations under stock tickers.

Those are probably professional conspiracy theorists with no other knowledge that everything is regulated by a clandestine secret society, and since we know their response to everything, we don't need to take their ideas seriously.

I am fairly far removed from pharma in my own research, but a few students get hired there to do chemistry, so my knowledge is somewhat limited and second-hand. And occasionally I read something like this: https://www.bloomberg.com/news/articles/2019-05-03/antibiotics-aren-t-profitable-enough-for-big-pharma-to-make-more
I am not sure how close to reality it is, since one can not trust a lot of media analyses.

Note the part where it says: Don't use it. Hold it in reserve.

Article could have been written in the 90s and still been accurate.

I truly think phages are the future. It's amazing that USSR states were working on that back when penicillin was discovered.

They were just too early. Future tech is going to (current already has) make that work swimmingly.

Also says: They're made to be used as little as possible.

If they were used they'd be profitable.

Holding in reserve is the right idea. Just need some incentive to fund them (better) anyway. Can't expect a business to do that.

I like the idea of funding phage research instead though.

Give the little bacterial cock-a-roaches corona virus:

https://www.google.com/amp/s/www.livescience.com/amp/65455-superbug-killing-phage-therapy-how-it-works.html

Heraclitusstudent says

Yes, government imposed safety tests are known to be too drastic. No one ever dies from a FDA approved drug!

Did you listen to Trump's speech with the CDC this week? In particular when the director guy spoke?

"We'll have vaccine in about two months"

Then he goes on and on about the durations of this and that trial etc., and finally says 1-1.5 or 2 years.

And that were already testing some in china right now.

Fucking FDA man.

Btw I hear people typically don't build immunity to corona even after having the disease - can be reinfected.
Wonder if they can actually create a vaccine.
There is no vaccine against the common cold.
This might just be the super common cold that will stay ever after. (and happens to save Social Security?)

Heraclitusstudent says

Btw I hear people typically don't build immunity to corona even after having the disease - can be reinfected.
Wonder if they can actually create a vaccine.
There is no vaccine against the common cold.
This might just be the super common cold that will stay ever after. (and happens to save Social Security?)

The reason there's no vaccine for the common cold is that there are hundreds of types of cold viruses and unless you find a common link you can't and don't want to vaccinate yourself against all of them - totally different from the CV causing Covid-19 which has not mutated and is a single virus well known by now. The observation of re-infection may be due to faulty tests not detecting a still ongoing infection, or it can be due to other factors related to the virus which are again not uncommon at all. There are tons of viruses you can get reinfected with or which reactivate - most childhood diseases you can get as an adult again, most notably Chickenpox -> Shingles (varicella-zoster). None of that makes it a super bug and the hype around this is still overblown. Most countries act strongly also because their populace demands it, and seeing the media switching from impeachment to non-stop news about the CV surely makes this very suspicious. Nothing more than a glorified flu, this has gotten too much media attention in the US, because after impeachment they have nothing left to blame on OrangeManBad!

And they're closing in on the common cold: https://scopeblog.stanford.edu/2019/09/16/scientists-close-in-on-a-cure-for-the-common-cold/

A second person in California was diagnosed with the coronavirus despite a lack of known ties to other infected patients or areas. It’s a further sign that the disease is likely spreading in some parts of the U.S.

https://finance.yahoo.com/news/germany-boosts-border-checks-google-215438086.html

Meaning people have it and just don't realize it.
There will be 100 cases in CA in a week.

mell says

the hype around this is still overblown. Most countries act strongly also because their populace demands it, and seeing the media switching from impeachment to non-stop news about the CV surely makes this very suspicious. Nothing more than a glorified flu, this has gotten too much media attention in the US, because after impeachment they have nothing left to blame on OrangeManBad!

Glorified flu 10x as lethal, that kills people in otherwise good health, and completely overloads the healthcare system where it happens.
Also the governments in China and elsewhere have every political reasons to minimize it and under report cases.
China strongly resisted strong measures until they were forced. Europe strongly resists travel limitations even now.
They DON'T make a big deal to keep people happy. They are forced to.

Heraclitusstudent says

mell says

the hype around this is still overblown. Most countries act strongly also because their populace demands it, and seeing the media switching from impeachment to non-stop news about the CV surely makes this very suspicious. Nothing more than a glorified flu, this has gotten too much media attention in the US, because after impeachment they have nothing left to blame on OrangeManBad!

Glorified flu 10x as lethal, that kills people in otherwise good health, and completely overloads the healthcare system where it happens.
Also the governments in China and elsewhere have every political reasons to minimize it and under report cases.
China strongly resisted strong measures until they were forced. Europe strongly resists travel limitations even now.
They DON'T make a big deal to keep people happy. They are forced to.

The flu brings hospital capacities and sometimes meds to an overload whenever it's a sever season. Nothing new. It's not 10 x lethal, outside of China it's a bit more lethal than the flu. That may change for the better if it becomes endemic. The reason it puts so much strain on everything is that it's being dealt with by enacting extraordinary measures for every infected person, which they don't do for the flu. So yeah, it def will have an impact, mainly on the Q1 economy of suppliers and tourism, we know Europe is a bit laxer than the US at the border. They will be a good testing ground for the true severity of the CV. We'll see how Italy, Germany etc. evolve. My prediction is by quarantining the sick and calling off major gatherings for a while they will get control of it.

just_dregalicious says

Give the little bacterial cock-a-roaches corona virus:

nice, I recall that one of my friends back in USSR was working on phages in late 1980's. Never thought about it afterwards, thanks for reminding.

HEYYOU says

What's your worse case scenario for America & the globe from the corona virus?

Worst case is that very few people die and we are still grossly overpopulated.

Booger says

Worst case is that very few people die and we are still grossly overpopulated.

If it clears out the Sunol Grade at rush hour, it was all worth it.

Another graph from the Wikipedia which shows that the number of cases has leveled off in China.

When that graph starts falling, expect the stock market to start rising.

Patrick says

When that graph starts falling, expect the stock market to start rising.

I don't think this is paying attention to the situation at hand.

It falls in China because of major clamp down on activity, forcing people to stay at home, forcing them to report temperatures, closing schools, severely limiting transportation, etc... that's a severe economic disruption by itself.

It's obvious that this thing will go increasing exponentially in the west until we do the same as China. It's a direct straight line from here to there. So huge economic disruption is baked in. It would take a miracle for this not to happen. For example, maybe warmer temperature will make it go away? Like yes - miracle.

It will also happen in places that don't have the medical infrastructure or social authority to do something like China did. I.e. this thing will keep moving around and be a pain long term.

Don't kid yourself.

The flu has killed over 15000 people in the US alone and is just reaching its peak. If people confine themselves when they get sick with flu like symptoms this is nothing more than another serious flu. Not good but by far not as bad as the media shills make it appear. These things will recur every decade or so, most will either disappear or become mild and endemic.

mell says

It's not 10 x lethal, outside of China it's a bit more lethal than the flu.

This is the first time I heard this. I just heard Italy had about 3% mortality rate, while I usually hear 2%, sometimes up to 3%, for China.

edit - I saw a source claim 3.5% for Iran.

Do you think maybe the lower death rate outside China is due to them receiving better/any hospital care? I'd imagine China hospitals overloaded quickly, leaving most with little to no care. That can happen happen outside of China too, given a bit of time.

edit - I'm now questioning "the death rate being lower outside of China" given that Italy and Iran are the top locations, and they have the same or higher death rate.