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Risk factors and clinical features
https://www.imperial.ac.uk/news/19721...
https://www.medrxiv.org/content/10.11...

Features of 16,749 hospitalised UK patients with COVID-19 (Imperial college, 28th April)
Prospective observational cohort study
The largest detailed description of COVID-19 in Europe
166 UK hospitals
6th February to18th April 2020

N = 16,749 people hospitalised with COVID-19
This represents 14.7% of all people who have tested positive for COVID-19 in the UK
239 patients (2.0%) under 18 years
139 patients (1.1%) are under 5 years of age
Men 60.2%, women 39.8%
Results
Median age 72 years
IQR 57 – 82
Median duration of symptoms before admission was 4 days
IQR 1- 8
Median duration of hospital stay 7 days

Commonest comorbidities
Chronic cardiac disease, 29%
Uncomplicated diabetes, 19%
Non-asthmatic chronic pulmonary disease, 19%
Asthma, 14%
No documented reported comorbidity, 47%

Increased age and comorbidities including obesity were associated with a higher probability of mortality

Clinical features
Cough, 70%
Fever 69%
Shortness of breath 65%
High degree of overlap between the three common symptoms
Reported no symptoms, 4%
Clusters of symptoms were found
1. The most common symptom cluster encompass the respiratory system: cough, sputum, shortness of breath, fever, sore throat, runny nose, ear pain, wheeze, chest pain
2. Musculoskeletal symptoms: myalgia, joint pain and fatigue
3. Enteric symptoms: abdominal pain, vomiting and diarrhoea
29% of all patients complained of enteric symptoms on admission, mostly in association with respiratory symptoms
4% of all patients described enteric symptoms alone.
Outcomes
49% discharged alive
33% died
17% continued to receive care

17% required admission to High Dependency or Intensive Care Units
of these
31% were discharged alive
45% died
24% continued to receive care

Of those receiving mechanical ventilation,
20% were discharged alive
53% died
27% remained in hospital
Pregnant women 6%
Pregnancy was not associated with mortality, in apparent contrast with influenza
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