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Geometric Mean Titer (GMT)


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2021 Oct 1, 1:52pm   1,124 views  4 comments

by EBGuy   ➕follow (0)   💰tip   ignore  

A couple of weeks ago Pfizer announced promising results for 5-11 year olds. It included a new GMT for 16-25 year olds (1146.5). I became curious about this as the CDC data for 12-15 year olds had previously showed Immunobridging data comparing geometric mean antibody titers (GMT) in 12-15-year-olds to those in 16-25 year-olds, for whom clinical efficacy was previously established, were provided in support of efficacy. The geometric mean ratio (GMR) for antibodies in 12–15-year-olds compared to 16–25-year-olds was 1.76 (95% CI:1.47, 2.10), and met the noninferiority criteria. This is based on the GMT of 705.1 for 16-25 year olds from this study Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. This suggested (at least to me) that the dosing for 12-15 year olds may be off. The newly announced GMT of 1146.5 (for 16-25 year olds) makes the the GMR for 12-14 year olds less pronounced. Yet why did the GMT change so dramatically -- my only guess is that they used a larger sample size in the subsequent study. Here are the various GMTs linked to their respective studies (or press releases).
Geometric Mean Titer (GMT)
Under 5 in Phase 2/3 (3 mcg dose)
5-11 year old: 1,197.6 (10 mcg dose)
12-14 years old: 1,239.5 (30 mcg dose)
16-25 years old: 1,146.5 (30 mcg dose) or 705.1
I still think the dosing is likely wrong for 12-15 year olds and it should be in the 20 mcg range. I'm guessing this is why the UK is only doing one shot (for now) for minors. I think it is unlikely that the FDA ever grants full Approval for 12-15 year olds and more more likely it remains under the EUA. Anyone (DR6 or others?) want to weigh in on the changing GMT issue for 16-25 year olds? Has anyone seen the GMT discussed elsewhere?

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1   Patrick   2021 Oct 1, 1:56pm  

It is utter insanity to mass inject experimental drugs into children for a disease which is less likely to kill them than getting hit by lightning.

Anyone advocating jabbing children is evil.
2   mell   2021 Oct 1, 2:07pm  

Patrick says
It is utter insanity to mass inject experimental drugs into children for a disease which is less likely to kill them than getting hit by lightning.

Anyone advocating jabbing children is evil.


There are no other countries mandating experimental vaccines for children, maybe the prison colony. The US has lost its way. It's time for people to rise up. What pisses me off so much is that the older generation(s) let it happen after they got their rebel years in. I don't recognize this state anymore that grew up on punk rock, ska, metal, hippie shit and a healthy dose of do-it-yourself anarchy.
3   mell   2021 Oct 1, 3:04pm  

EBGuy says
A couple of weeks ago Pfizer announced promising results for 5-11 year olds. It included a new GMT for 16-25 year olds (1146.5). I became curious about this as the CDC data for 12-15 year olds had previously showed Immunobridging data comparing geometric mean antibody titers (GMT) in 12-15-year-olds to those in 16-25 year-olds, for whom clinical efficacy was previously established, were provided in support of efficacy. The geometric mean ratio (GMR) for antibodies in 12–15-year-olds compared to 16–25-year-olds was 1.76 (95% CI:1.47, 2.10), and met the noninferiority criteria. This is based on the GMT of 705.1 for 16-25 year olds from this study Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. This suggested (at least to me) that the dosing for 12-15 year olds may be off. The newly announced GMT of 1146.5 (for 16-25 year olds) make...


Thanks for the analysis but I doubt they'll withhold full approval for 12-15. The fda/cdc are deeply corrupt
4   Robert Sproul   2021 Oct 1, 3:33pm  

mell says
I don't recognize this state anymore that grew up on punk rock, ska, metal, hippie shit and a healthy dose of do-it-yourself anarchy.

Some of that teen angst, testosterone rage, and rebellion against authority has accrued to Antifa of all places.
And they, being clueless and easily led, are beating up "anti-vaxers" and "transphobes".

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