patrick.net

Methods: Intranasal administration is a non-invasive method of drug delivery that may bypass the
BBB, allowing therapeutic substances direct access to the brain. However, intranasal administration
produces quite low drug concentrations in the brain due limited nasal mucosal permeability and the
harsh nasal cavity environment. Pre-clinical studies using encapsulation of drugs in nanoparticulate
systems improved the nose to brain targeting and bioavailability in brain. However, the toxic effects
of nanoparticles on brain function are unknown.