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The Spike Protein, Acute Kidney Injury and Heart Failure: Induction of a Slow Death
The interplay between kidneys and the heart after Spike Protein injury may initiate a lethal feedback loop刺突蛋白、急性肾损伤和心力衰竭：缓慢死亡的诱导

https://open.substack.com/pub/wmcresearch/p/the-spike-protein-acute-kidney-injury

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Ascertainment timeline. Time periods of ascertainment of baseline conditions, vital signs, medications, and exposure (AKI events) in relation to outcome (HF diagnosis date). Echocardiogram used to classify HF as HFpEF or HFrEF ascertained in 30 days before and up to 1 year following HF diagnosis date

One of the most glaring effects of the Spike Protein on the body (among many) is its apparent ability to induce Acute Kidney Injury (AKI). I believe this is something that clinicians need to be particularly aware of. After reviewing the evidence, it would seem prudent that any patients who have experienced AKI from COVID/Spike Transfection should be monitored for Heart Failure (HF). The connection between AKI and HF is the causative reason for concern.

First, let’s discuss how the Spike Protein may cause AKI. The most likely mechanism is the Spike Protein’s ability to mimic Acute Tubular Necrosis. It accomplishes this in a most devious manner. 刺突蛋白、急性肾损伤和心力衰竭：缓慢死亡的诱导
刺突蛋白损伤后肾脏和心脏之间的相互作用可能会启动致命的反馈循环。
沃尔特·M·切斯纳特
1月13日

在应用程序中阅读

确定时间表。 确定与结果（心力衰竭诊断日期）相关的基线状况、生命体征、药物和暴露（AKI 事件）的时间段。 用于将 HF 分类为 HFpEF 或 HFrEF 的超声心动图在 HF 诊断日期之前 30 天和之后 1 年内确定

刺突蛋白对身体最明显的影响之一（其中之一）是它明显能够诱发急性肾损伤 (AKI)。 我相信这是临床医生需要特别注意的。 在审查了证据后，谨慎的做法是，任何因 COVID/Spike 转染而出现 AKI 的患者都应接受心力衰竭 (HF) 监测。 AKI 和 HF 之间的联系是令人担忧的原因。

首先，我们来讨论一下刺突蛋白如何导致 AKI。 最可能的机制是刺突蛋白具有模拟急性肾小管坏死的能力。 它以一种最狡猾的方式实现了这一点。

READ IN APP

Ascertainment timeline. Time periods of ascertainment of baseline conditions, vital signs, medications, and exposure (AKI events) in relation to outcome (HF diagnosis date). Echocardiogram used to classify HF as HFpEF or HFrEF ascertained in 30 days before and up to 1 year following HF diagnosis date

One of the most glaring effects of the Spike Protein on the body (among many) is its apparent ability to induce Acute Kidney Injury (AKI). I believe this is something that clinicians need to be particularly aware of. After reviewing the evidence, it would seem prudent that any patients who have experienced AKI from COVID/Spike Transfection should be monitored for Heart Failure (HF). The connection between AKI and HF is the causative reason for concern.

First, let’s discuss how the Spike Protein may cause AKI. The most likely mechanism is the Spike Protein’s ability to mimic Acute Tubular Necrosis. It accomplishes this in a most devious manner.

The present study demonstrates that expression of the spike protein in HEK293-ACE2+ cells leads to cell fusion, progressive syncytia formation, and the lifting off and sloughing of sheets of fused cells from the monolayer, the latter giving rise to focal areas of denudation. These findings are reminiscent of what occurs during acute tubular injury/necrosis in AKI wherein injured renal epithelial cells, adhering to one another, detach from the tubular basement membrane and slough into the urinary space. The present study, to the best of our knowledge, is the first to call attention to this sloughing phenomenon in spike protein-expressing kidney cells and its mimicry of what may occur in the acute tubular necrosis variant of AKI. The relevance of syncytia to AKI is supported by a quite recent postmortem study in patients who died from COVID-19; in 28% of autopsy cases the presence of syncytia was reported in the kidney [23].

The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications…。在应用程序中阅读

确定时间表。 确定与结果（心力衰竭诊断日期）相关的基线状况、生命体征、药物和暴露（AKI 事件）的时间段。 用于将 HF 分类为 HFpEF 或 HFrEF 的超声心动图在 HF 诊断日期之前 30 天和之后 1 年内确定

刺突蛋白对身体最明显的影响之一（其中之一）是它明显能够诱发急性肾损伤 (AKI)。 我相信这是临床医生需要特别注意的。 在审查了证据后，谨慎的做法是，任何因 COVID/Spike 转染而出现 AKI 的患者都应接受心力衰竭 (HF) 监测。 AKI 和 HF 之间的联系是令人担忧的原因。

首先，我们来讨论一下刺突蛋白如何导致 AKI。 最可能的机制是刺突蛋白具有模拟急性肾小管坏死的能力。 它以一种最狡猾的方式实现了这一点。

本研究表明，HEK293-ACE2+细胞中刺突蛋白的表达导致细胞融合、进行性合胞体形成以及融合细胞片从单层上剥离和脱落，后者导致局部剥脱区域。 这些发现让人想起 AKI 中急性肾小管损伤/坏死期间发生的情况，其中受损的肾上皮细胞相互粘附，从肾小管基底膜脱离并脱落到尿道中。 据我们所知，本研究首次引起人们对表达刺突蛋白的肾细胞中这种脱落现象的关注，及其对 AKI 急性肾小管坏死变异中可能发生的情况的模仿。 最近一项针对死于 COVID-19 的患者的尸检研究支持了合胞体与 AKI 的相关性； 据报道，28% 的尸检病例中肾脏存在合胞体 [23]。

SARS-CoV-2 的刺突蛋白诱导血红素加氧酶-1：病理生理学意义…