SARS-CoV-2 causes gastric damage and Galectin-3 deficiency
SARS-COV-2造成胃损伤，并 Galectin-3缺乏
A few years ago, as I attempted to uncover all the hidden things in SARS-CoV-2’s Spike Protein, specific parts of the chimeric protein came to mind quite quickly, especially the now-infamous “HIV inserts”. The Furin Cleavage Site is one of them, acting as a multi-functional protein, enabling the virus to bind to ACE2 and infect your cells, acts as a superantigen, it acts like GP120 in regards to how toxic it is to your body, among other effects. A very pernicious effect is that it enables the virus to bind to Endotoxin, catapulting its inflammatory prowess.
Another “insert” wasn’t exactly an insert, it is a naturally occurring section in certain coronaviruses. It’s N-Terminal Domain (NTD), or otherwise called “The Galectin-fold”, because it is a perfect mimic of human Galectin, specifically Galectin-3. The article below has an overview of what Galectin is, with an intense focus on 3. In the context of the virus, the NTD is what immunology calls a “super antigenic site”, meaning your immune system is highly sensitive towards that specific part of the virus, and it will seek it like a highly sophisticated missile. Mutations in this region enable the virus to escape the immune system and your antibodies, and it also enables the virus to change how sugars coat itself, enabling it to further escape immune responses.
SARS-CoV-2 causes gastric damage and
Galectin-3 deficiency
SARS-COV-2造成胃损伤，并
Galectin-3缺乏
A few years ago, as I attempted to uncover all the hidden things in SARS-CoV-2’s Spike Protein, specific parts of the chimeric protein came to mind quite quickly, especially the now-infamous “HIV inserts”. The Furin Cleavage Site is one of them, acting as a multi-functional protein, enabling the virus to bind to ACE2 and infect your cells, acts as a superantigen, it acts like GP120 in regards to how toxic it is to your body, among other effects. A very pernicious effect is that it enables the virus to bind to Endotoxin, catapulting its inflammatory prowess.
Another “insert” wasn’t exactly an insert, it is a naturally occurring section in certain coronaviruses. It’s N-Terminal Domain (NTD), or otherwise called “The Galectin-fold”, because it is a perfect mimic of human Galectin, specifically Galectin-3. The article below has an overview of what Galectin is, with an intense focus on 3.
In the context of the virus, the NTD is what immunology calls a “super antigenic site”, meaning your immune system is highly sensitive towards that specific part of the virus, and it will seek it like a highly sophisticated missile. Mutations in this region enable the virus to escape the immune system and your antibodies, and it also enables the virus to change how sugars coat itself, enabling it to further escape immune responses.
https://open.substack.com/pub/hiddencomplexity/p/sars-cov-2-causes-gastric-damage
几年前，当我试图揭开SARS-CoV-2的尖峰蛋白中所有隐藏的东西时，很快就想到了嵌合蛋白的特定部分，特别是现在臭名昭著的“HIV插入物”。富林裂解位点就是其中之一，作为一种多功能蛋白质，使病毒能够与ACE2结合并感染你的细胞，作为一种超级抗原，它的作用就像GP120一样，因为它对你的身体有毒，以及其他影响。一个非常有害的效果是，它使病毒能够与内毒素结合，从而促进其炎症能力。
另一个“插入”并不完全是插入物，它是某些冠状病毒中自然发生的部分。它是N端结构域（NTD），也称为“Galectin-fold”，因为它是人类Galectin，特别是Galectin-3的完美模仿。以下文章概述了什么是Galectin，重点关注3。
在病毒的背景下，NTD是免疫学所说的“超级抗原位点”，这意味着你的免疫系统对病毒的特定部分非常敏感，它将像高度复杂的导弹一样寻找它。该区域的突变使病毒能够逃脱免疫系统和你的抗体，它还使病毒能够改变糖的覆盖方式，使其能够进一步逃脱免疫反应。