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Creatine for Alzheimer’s? Early Human Data Just Dropped

A small but important pilot trial just tested creatine monohydrate in patients with Alzheimer’s disease.

Here’s what stood out:

1. Feasible and well-tolerated 20 g per day for 8 weeks, 95 percent hit compliance targets, and only mild side effects

2. Brain energy actually increased. Brain total creatine rose by ~11 percent, measured directly with MR spectroscopy

3. Cognition improved: Gains in global cognition, with the strongest effects in working memory, attention, and reading tasks. Notable in a disease where decline is expected

4. Biology makes sense. Alzheimer’s involves impaired brain energy metabolism. Creatine supports ATP buffering and mitochondrial function

5. Still early, single-arm pilot. Small sample, needs larger placebo-controlled trials

This is not a cure, but it is one of the first human signals that targeting brain bioenergetics with something simple and inexpensive may matter. Definitely worth watching.

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70101 肌酸治疗阿尔茨海默病？ 早期人类数据刚刚丢失

一项小型但重要的试点试验刚刚在阿尔茨海默病患者中测试了一水肌酸。

以下是突出的内容：

1. 可行且耐受性良好，每天 20 克，持续 8 周，95% 达到依从性目标，且副作用轻微

2.大脑能量确实增加了。 通过 MR 光谱直接测量，大脑总肌酸增加约 11%

3. 认知能力提高：整体认知能力提高，对工作记忆、注意力和阅读任务的影响最强。 在预计会下降的疾病中值得注意

4. 生物学是有道理的。 阿尔茨海默病涉及大脑能量代谢受损。 肌酸支持 ATP 缓冲和线粒体功能

5. 还处于早期阶段，单臂飞行员。 小样本，需要更大的安慰剂对照试验

这不是一种治愈方法，但它是第一个人类信号之一，表明用简单且廉价的东西针对大脑生物能量学可能很重要。 绝对值得一看。

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70101

Your VO₂ max might be protecting your brain, not just your heart.

Here’s what the science is telling us:

1. VO₂ max is one of the strongest predictors of longevity and overall survival

2. Higher aerobic fitness is linked to greater brain myelination, especially with aging

3. Poor fitness is associated with earlier and faster myelin decline, a key feature of cognitive aging

4. The biggest brain benefits of fitness appear in midlife and older adults

5. Exercise likely supports myelin via reduced inflammation, better metabolism, and neurotrophic signaling.

Train your VO₂ max for performance if you want.

Train it for your brain if you want to stay sharp longer.

https://www.physiologicallyspeaking.com/p/physiology-friday-232-higher-aerobic 您的最大摄氧量可能会保护您的大脑，而不仅仅是您的心脏。

科学告诉我们的是：

1. 最大摄氧量是长寿和总体生存的最强预测因素之一

2. 较高的有氧适能与较高的脑髓鞘形成有关，尤其是随着年龄的增长

3. 健康状况不佳与髓鞘质较早且较快的衰退有关，这是认知衰老的一个关键特征

4. 健身对大脑的最大好处出现在中年和老年人身上

5. 运动可能通过减少炎症、改善新陈代谢和神经营养信号传导来支持髓磷脂。

如果您愿意，可以训练您的最大摄氧量以提高表现。

如果您想更长时间地保持敏锐，请对您的大脑进行训练。

https://open.substack.com/pub/bradyholmer/p/physiology-friday-232-higher-aerobic

https://www.physiologicallyspeaking.com/p/physiology-friday-232-higher-aerobic