How Alcohol works
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How Alcohol works

By Tenpoundbass following x   2017 Aug 11, 11:53am 419 views   7 comments   watch   sfw   quote     share    

1   Ceffer   ignore (1)   2017 Aug 11, 11:57am   ↑ like (0)   ↓ dislike (0)     quote      

Can't you get it to work better than that?

2   BayAreaObserver   ignore (1)   2018 Jan 9, 2:31am   ↑ like (1)   ↓ dislike (0)     quote      

How alcohol damages stem cell DNA and increases cancer risk.

Drinking alcohol produces a harmful chemical in the body which can lead to permanent genetic damage in the DNA of stem cells, increasing the risk of cancer developing, according to research published on Wednesday.

Working with mice in a laboratory, British scientists used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol.

Their findings offered more detail about how alcohol increases the risk of developing 7 types of cancer, including common forms such as breast and bowel cancer. It also showed how the body seeks to defend against the damage alcohol can do. "Some cancers develop due to DNA damage in stem cells. While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage," said Ketan Patel, a professor at the Medical Research Council Laboratory of Molecular Biology, who co-led the study.

The World Health Organization's International Agency for Research on Cancer classifies alcohol as a Group 1 carcinogen, citing "convincing evidence" it causes cancer in humans.

A study published in 2011 found that alcohol is responsible for around 4% of all cancer in Britain - equating to around 12,800 cases a year.

The the study, published in Nature, Patel's team gave diluted alcohol to mice and then analyzed the effect on the animals' DNA. They found that acetaldehyde can break and damage DNA within blood stem cells, permanently altering the DNA sequences within these cells.

This is important, Patel said, because when healthy stem cells become faulty, they can give rise to cancerous cells.

3   errc   ignore (2)   2018 Jan 9, 4:34am   ↑ like (3)   ↓ dislike (0)     quote      

I’ve always thought any anecdotes or “studies” that claim benefits from alcohol are bullshit. As much fun as it was to get wasted as a kid, I don’t miss it at all. The friends I have who give up booze permanently can’t believe how much healthier they feel for it. Should it be such big surprise that giving up poisoning oneself with a deadly toxin leads to better health?

Propaganda works. The government loves the populace being drunk and stupid, which is why they encourage people to drink. The government hates when people are open minded and can avoid the healthcare racket, so they put you in prison if you consume dry flowers.
4   anon_33654   ignore (0)   2018 Jan 9, 10:56am   ↑ like (1)   ↓ dislike (0)     quote      

errc says
The friends I have who give up booze permanently can’t believe how much healthier they feel for it. Should it be such big surprise that giving up poisoning oneself with a deadly toxin leads to better health?

There's absolutely nothing wrong with having 3 drinks or less in a day occasionally as far as physical side effects go.

Besides, there are a couple of guidelines you can follow if you want to minimize alcohol related health problems:

1) No more than 4 drinks in 1 day AND no more than 14 drinks in 1 week = moderate drinking
2) Nor more than 2 drinks in 1 day AND no more than 14 drinks in 1 week = low risk drinking

If you follow these and don't cheat, chances are great that you will never develop alcohol related health issues.
5   Tenpoundbass   ignore (6)   2018 Jan 9, 11:06am   ↑ like (0)   ↓ dislike (0)     quote      

anon_33654 says
1) No more than 4 drinks in 1 day AND no more than 14 drinks in 1 week = moderate drinking

According to NPR they now call that "Binge Drinking" they had a new word for a Rummy as well. Alcohol Challenged or some Liberal retarded name.
I can't help but so transparently see, that they are setting up a situation where they can claim someone they disagree with has a drinking problem, after they shadow them and document their drink count in a given night.
"Ah HA! See! He's Alcohol Challenged!"
I promise to punch the first one that says it to me.
6   BayAreaObserver   ignore (1)   2018 Jan 14, 6:17pm   ↑ like (1)   ↓ dislike (0)     quote      

Scientists explore drug’s value in treating both alcoholism and PTSD.

The link between addiction and mental health disorders may be firmly established in scientific circles, but treatments designed to address them together are uncommon.

Some University of Maryland researchers may be taking a promising step to tackle two such intractable, but often related conditions: alcoholism and post-traumatic stress disorder.

Dr. Bankole Johnson, an addiction and brain science expert and professor of psychiatry in the University of Maryland School of Medicine, is leading a team launching a five-year study of the effectiveness of a drug called pregablin for treating alcoholism and PTSD together.

Known commercially as Lyrica, pregablin is now used to treat epileptic seizures, nerve pain and anxiety. Past studies also suggested it helps treat alcoholism, but that use has not been approved by the U.S. Food and Drug Administration.

“There is a lot of suffering among people with PTSD and people with alcoholism, and they are at extreme risk for harming themselves,” Johnson said. “So this could be particularly important for treatment.”

Johnson said doctors use drugs to treat anxiety or to detox a patient, but there is little research into what works for both. Researchers are recruiting people in Baltimore who served in combat roles in the military or were victims of domestic abuse, for example, and turned to alcohol, perhaps to “self-medicate.”

Johnson said pregablin is promising because it modulates over-active neurotransmitters, or chemical signals, from nerve cells that control the drive to use alcohol and the effects of anxiety. Some users say it has Valium-like effects, but Johnson said it’s far less addictive.

Any discovery of a medication to treat alcoholism and a severe mental health disorder could help reduce a persistent problem, he said.

While opioids such as heroin and fentanyl have grabbed most of the headlines because of a surge in related overdose deaths, alcohol continues to kill people.

Nationally, the U.S. Centers for Disease Control and Prevention reports that alcohol use led to about 88,000 deaths each year from 2006 to 2010.

A new report from the Trust for America’s Health counted more than a million deaths tied to alcohol, drugs and suicide in the past decade, with alcohol deaths up 37 percent and suicides increasing 28 percent from 2010 to 2015. The group says it points to an epidemic of pain, despair, disconnection and lack of opportunity and the need for a “national strategy to improve resilience.”

7   BayAreaObserver   ignore (1)   2018 Jan 14, 6:19pm   ↑ like (1)   ↓ dislike (0)     quote      

This Extremely Common Drug Given to Alcoholics Also Kills Cancer Cells, and We Finally Know Why.

Disulfiram (Antabuse) is a drug given to alcoholics to prevent them from drinking, but for decades doctors have noticed the medication appears to have an unexpected side effect: fighting cancer. Now, new research from the Karolinska Institute in Sweden has revealed the biological mechanism behind Antabuse's effect on cancer.

The study, published earlier this week in Nature, is the culmination of years of research and the combined efforts of scientists from five countries. In the paper, the team explains how Antabuse appears to “freeze” tumor growth by inhibiting an important protein.

However, as shown in this new study, Antabuse has another effect on the body. For their study, the researchers observed the drug's effect on both living mice and on human cancer cells. In doing so, they noted that when the drug is metabolized it causes the protein, NPL4, to clump together with the enzyme p97, immobilizing the protein. This “freezes” the cancer cells and prevents them from disposing of unnecessary proteins. The build-up stresses the cancer cells and eventually causes them to die, Science Mag reported.


Full Article From Science Magazine cited above:

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