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Ivermectin

By Patrick follow Patrick   2021 May 9, 10:24pm 356 views   18 comments   watch   nsfw   quote   share    


https://sebastianrushworth.com/2021/05/09/update-on-ivermectin-for-covid-19/

Back in January I wrote an article about four randomized controlled trials of ivermectin as a treatment for covid-19 that had at that time released their results to the public. Each of those four trials had promising results, but each was also too small individually to show any meaningful impact on the hard outcomes we really care about, like death. When I meta-analyzed them together however, the results suddenly appeared very impressive. Here’s what that meta-analysis looked like:



It showed a massive 78% reduction in mortality in patients treated with covid-19. Mortality is the hardest of hard end points, which means it’s the hardest for researchers to manipulate and therefore the least open to bias. Either someone’s dead, or they’re alive. End of story.

You would have thought that this strong overall signal of benefit in the midst of a pandemic would have mobilized the powers that be to arrange multiple large randomized trials to confirm these results as quickly as possible, and that the major medical journals would be falling over each other to be the first to publish these studies.

That hasn’t happened.

Rather the opposite, in fact. South Africa has even gone so far as to ban doctors from using ivermectin on covid-19 patients. And as far as I can tell, most of the discussion about ivermectin in mainstream media (and in the medical press) has centred not around its relative merits, but more around how its proponents are clearly deluded tin foil hat wearing crazies who are using social media to manipulate the masses.

In spite of this, trial results have continued to appear. That means we should now be able to conclude with even greater certainty whether or not ivermectin is effective against covid-19. Since there are so many of these trials popping up now, I’ve decided to limit the discussion here only to the ones I’ve been able to find that had at least 150 participants, and that compared ivermectin to placebo (although I’ll add even the smaller trials I’ve found in to the updated meta-analysis at the end).

As before, it appears that rich western countries have very little interest in studying ivermectin as a treatment for covid. The three new trials that had at least 150 participants and compared ivermectin with placebo were conducted in Colombia, Iran, and Argentina. We’ll go through each in turn. ...

What we see is a 62% reduction in the relative risk of dying among covid patients treated with ivermectin. That would mean that ivermectin prevents roughly three out of five covid deaths. The reduction is statistically significant (p-value 0,004). In other words, the weight of evidence supporting ivermectin continues to pile up. It is now far stronger than the evidence that led to widespred use of remdesivir earlier in the pandemic, and the effect is much larger and more important (remdesivir was only ever shown to marginally decrease length of hospital stay, it was never shown to have any effect on risk of dying).

I understand why pharmaceutical companies don’t like ivermectin. It’s a cheap generic drug. Even Merck, the company that invented ivermectin, is doing it’s best to destroy the drug’s reputation at the moment. This can only be explained by the fact that Merck is currently developing two expensive new covid drugs, and doesn’t want an off-patent drug, which it can no longer make any profit from, competing with them.

The only reason I can think to understand why the broader medical establishment, however, is still so anti-ivermectin is that these studies have all been done outside the rich west. Apparently doctors and scientists outside North America and Western Europe can’t be trusted, unless they’re saying things that are in line with our pre-conceived notions.


And HCQ falls into that same bucket. Even worse - to admit HCQ works would be to admit Trump was right about something.

Liberals would rather that millions die than that Trump be allowed to be right about anything. They hate Trump more than they love their fellow humans.
1   Shaman   ignore (2)   2021 May 10, 8:01am     ↓ dislike (0)   quote   flag      

Patrick says
They hate Trump more than they love their fellow humans.


In all honesty, that’s a low low bar. True Leftists love nobody but themselves and love nothing but power.
2   farmer2021   ignore (10)   2021 May 13, 1:01pm     ↓ dislike (0)   quote   flag      

https://twitter.com/knapproductions/status/1392927268201275399
Just wondering if the WHO and world leaders have really got the public health as interest, or are they lining their pockets with money. I see the India covid cases have started to fall, first time in 2months. Why? Because they are taking Ivermectin:
4   Onvacation   ignore (6)   2021 May 31, 2:32pm     ↓ dislike (0)   quote   flag      

Dr. Pierre Kory on ivermectin for early covid treatment!


original link
/
From six months ago but still relevant.
5   Onvacation   ignore (6)   2021 May 31, 2:45pm     ↓ dislike (0)   quote   flag      

WE did not need an experimental biologic agent to fight this chimera. Ivermectin stops it dead in it's tracks.

The question is, why did THEY need it?
6   Patrick   ignore (1)   2021 May 31, 4:58pm     ↓ dislike (0)   quote   flag      

They needed the "vaccine" to gain profit and power.

There is nothing more to it.
7   Patrick   ignore (1)   2021 Jun 5, 4:41pm     ↓ dislike (0)   quote   flag      

https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial
View ORCID ProfileAsaf Biber, Michal Mandelboim, Geva Harmelin, Dana Lev, Li Ram, Amit Shaham, Ital Nemet, Limor Kliker, Oran Erster, Eli Schwartz
doi: https://doi.org/10.1101/2021.05.31.21258081
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
AbstractFull TextInfo/HistoryMetrics Preview PDF
Abstract
Background Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection.

Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at recruitment and then every two days. Primary endpoint was reduction of viral-load on the 6th day (third day after termination of treatment) as reflected by Ct level>30 (non-infectious level). The primary outcome was supported by determination of viral culture viability.

Results Eighty-nine patients were eligible (47 in ivermectin and 42 in placebo arm). Their median age was 35 years. Females accounted for 21·6%, and 16·8% were asymptomatic at recruitment. Median time from symptom onset was 4 days. There were no statistical differences in these parameters between the two groups.

On day 6, 34 out of 47 (72%) patients in the ivermectin arm reached the endpoint, compared to 21/ 42 (50%) in the placebo arm (OR 2·62; 95% CI: 1·09-6·31). In a multivariable logistic-regression model, the odds of a negative test at day 6 was 2.62 time higher in the ivermectin group (95% CI: 1·06–6·45). Cultures at days 2 to 6 were positive in 3/23 (13·0%) of ivermectin samples vs. 14/29 (48·2%) in the placebo group (p=0·008).

Conclusions There were significantly lower viral loads and viable cultures in the ivermectin group, which could lead to shortening isolation time in these patients.


Fauci suppressed not only HCQ but also Ivermectin.

Fauci is a mass murderer.
8   Blue   ignore (0)   2021 Jun 5, 5:56pm     ↓ dislike (0)   quote   flag      

A month back, a friend of mine back in India got Covid, 25 days after his first jab just before second one due and recovered fully in 10 days. He was able to convince the family to admit in hospital only if the oxygen level drops to significant low level. It was a stressful situation to the entire family.
He used Ivermectin (along with a second name I forgot) suggested by his doctor over the phone, instead of going to hospital after he heard lot of victims who are admitted got all sort of medications from nursing staff where doctors are absent in many cases! Medications include heavy doses of steroids, antibiotics etc, I suspect many cannot handle all these medications in a short period of the time and dies. Yet hospital charges exorbitant amount of money from their victims. In some cases they refuse to return dead body unless pay the bill in full. What a sad situation for those victim families. Still not too many are realizing the true picture of the medical and pharma industries.
9   richwicks   ignore (4)   2021 Jun 5, 6:01pm     ↓ dislike (0)   quote   flag      

Patrick says
They needed the "vaccine" to gain profit and power.

There is nothing more to it.


I don't think profit is an incentive anymore. It's only power.

The Federal Reserve can create as much money as they goddamned please.
10   mell   ignore (6)   2021 Jun 5, 6:10pm     ↓ dislike (0)   quote   flag      

richwicks says
Patrick says
They needed the "vaccine" to gain profit and power.

There is nothing more to it.


I don't think profit is an incentive anymore. It's only power.

The Federal Reserve can create as much money as they goddamned please.


Not without it eventually becoming worthless. Look at the dollar. They can print a lot to keep inflating their assets and not care about inflation for the common people, but they do have limits. Most of the wealth is created by creating demand artificially or coercion. The covid vaccines are a perfect example.
11   Onvacation   ignore (6)   2021 Jun 5, 6:24pm     ↓ dislike (0)   quote   flag      

richwicks says
The Federal Reserve can create as much money as they goddamned please.

And they know their days are numbered.
Fiat money only has value until it doesn't.
12   richwicks   ignore (4)   2021 Jun 5, 6:47pm     ↓ dislike (0)   quote   flag      

Onvacation says
richwicks says
The Federal Reserve can create as much money as they goddamned please.

And they know their days are numbered.
Fiat money only has value until it doesn't.


How many people own their car, their home, etc - outright?

The end of this is going to be a mass confiscation of physical wealth.
13   MisdemeanorRebellionNoCoupForYou   ignore (1)   2021 Jun 5, 9:35pm     ↓ dislike (0)   quote   flag      

richwicks says
I don't think profit is an incentive anymore. It's only power.


Yup. This is a great answer to "But if we regulate Twitter..." Twitter I think rarely makes a profit. WaPo also. They are "Loss Leaders" whose costs are paid to push a certain line, rather than traditional profit-seeking entities. This theory explains a lot of things they do that are counter productive, such as endorsing positions on CULTURAL issues that 2/3rd of Americans disagree with - including a solid majority of youth 18-29. So that throws the "Appeal to youth because future customers".

On a side note, I wonder if there is any research comparing the LOSS of long term customers turned off by BLM/LGBTQ+ vs. new customers onboarding. It certainly isn't appearing in current viewership, which is collapsing by double digits YoY.

ESPN, NBA, etc. have to be smoking crack not to see that the loss of long time viewership isn't offset by onboarding youths. IF they were profit maximizers, they wouldn't be pursuing the strategy they are, as today's 50-something sports fans are tomorrow's 70-something sports fans.
14   Patrick   ignore (1)   2021 Jun 5, 10:51pm     ↓ dislike (0)   quote   flag      

MisdemeanorRebellionNoCoupForYou says
Twitter I think rarely makes a profit. WaPo also. They are "Loss Leaders" whose costs are paid to push a certain line, rather than traditional profit-seeking entities.


This is the only rational explanation for their continuous alienation of large segments of the population.
16   ThreeBays   ignore (5)   2021 Jun 9, 1:00pm     ↓ dislike (0)   quote   flag      



Why does Peru (#1 in use of Ivermectin) have the most deaths per capita by far in the world?
Why does Hungary (#1 in Hydroxychloroquine) have the second most deaths per capita in the world?

Holy smoke, a population fatality rate of 0.56% in Peru and rising? Not an infection fatality rate, but the rate versus 100% of the population, meaning the IFR is way higher than that.
17   Patrick   ignore (1)   2021 Jun 9, 1:07pm     ↓ dislike (0)   quote   flag      

https://vitamindwiki.com/High-altitude+Cusco%2C+Peru+has+far+lower+rate+of+COVID-19+than+others+%28high+UVB+and+Vitamin+D%29+-+June+2020


Many of the COVID-19 infections are in tourists (who have not gotten lots of UVB), not locals

"....Cusco, 6.7 % of men are obese, compared to Lima, where 24.4 % are."


Maybe Ivermectin just isn't enough to save you if you're obese.
18   ThreeBays   ignore (5)   2021 Jun 9, 1:19pm     ↓ dislike (0)   quote   flag      

Patrick says
Maybe Ivermectin just isn't enough to save you if you're obese.


You're less at risk to begin with if you're not obese.

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