8
0

Ivermectin


 invite response                
2021 May 9, 10:24pm   81,922 views  629 comments

by Patrick   ➕follow (61)   💰tip   ignore  

https://sebastianrushworth.com/2021/05/09/update-on-ivermectin-for-covid-19/

Back in January I wrote an article about four randomized controlled trials of ivermectin as a treatment for covid-19 that had at that time released their results to the public. Each of those four trials had promising results, but each was also too small individually to show any meaningful impact on the hard outcomes we really care about, like death. When I meta-analyzed them together however, the results suddenly appeared very impressive. Here’s what that meta-analysis looked like:



It showed a massive 78% reduction in mortality in patients treated with covid-19. Mortality is the hardest of hard end points, which means it’s the hardest for researchers to manipulate and therefore the least open to bias. Either someone’s dead, or they’re alive. End of story.

You would have thought that this strong overall signal of benefit in the midst of a pandemic would have mobilized the powers that be to arrange multiple large randomized trials to confirm these results as quickly as possible, and that the major medical journals would be falling over each other to be the first to publish these studies.

That hasn’t happened.

Rather the opposite, in fact. South Africa has even gone so far as to ban doctors from using ivermectin on covid-19 patients. And as far as I can tell, most of the discussion about ivermectin in mainstream media (and in the medical press) has centred not around its relative merits, but more around how its proponents are clearly deluded tin foil hat wearing crazies who are using social media to manipulate the masses.

In spite of this, trial results have continued to appear. That means we should now be able to conclude with even greater certainty whether or not ivermectin is effective against covid-19. Since there are so many of these trials popping up now, I’ve decided to limit the discussion here only to the ones I’ve been able to find that had at least 150 participants, and that compared ivermectin to placebo (although I’ll add even the smaller trials I’ve found in to the updated meta-analysis at the end).

As before, it appears that rich western countries have very little interest in studying ivermectin as a treatment for covid. The three new trials that had at least 150 participants and compared ivermectin with placebo were conducted in Colombia, Iran, and Argentina. We’ll go through each in turn. ...

What we see is a 62% reduction in the relative risk of dying among covid patients treated with ivermectin. That would mean that ivermectin prevents roughly three out of five covid deaths. The reduction is statistically significant (p-value 0,004). In other words, the weight of evidence supporting ivermectin continues to pile up. It is now far stronger than the evidence that led to widespred use of remdesivir earlier in the pandemic, and the effect is much larger and more important (remdesivir was only ever shown to marginally decrease length of hospital stay, it was never shown to have any effect on risk of dying).

I understand why pharmaceutical companies don’t like ivermectin. It’s a cheap generic drug. Even Merck, the company that invented ivermectin, is doing it’s best to destroy the drug’s reputation at the moment. This can only be explained by the fact that Merck is currently developing two expensive new covid drugs, and doesn’t want an off-patent drug, which it can no longer make any profit from, competing with them.

The only reason I can think to understand why the broader medical establishment, however, is still so anti-ivermectin is that these studies have all been done outside the rich west. Apparently doctors and scientists outside North America and Western Europe can’t be trusted, unless they’re saying things that are in line with our pre-conceived notions.


And HCQ falls into that same bucket. Even worse - to admit HCQ works would be to admit Trump was right about something.

Liberals would rather that millions die than that Trump be allowed to be right about anything. They hate Trump more than they love their fellow humans.

« First        Comments 128 - 167 of 629       Last »     Search these comments

128   Karloff   2021 Sep 3, 9:32am  

This "horse de-wormer" programming is pathetically simplistic and obvious, but sadly still effective on a lot of people. If people refer to it like this I make a comparison as well to show how idiotic it is.

"Water? You mean that liquid that fish use to crap in?"
129   Eric Holder   2021 Sep 3, 10:36am  



Safe dosage or racist plot to kill colored people?
130   joshuatrio   2021 Sep 3, 12:44pm  

My dr is on the ivermectin train. Just got this email from here as they decided on their covid protocol:



I use a self-pay membership option, where neither myself or the doc is at the mercy of insurance payouts.
131   richwicks   2021 Sep 3, 1:10pm  

joshuatrio says
My dr is on the ivermectin train. Just got this email from here as they decided on their covid protocol:



I use a self-pay membership option, where neither myself or the doc is at the mercy of insurance payouts.


Can you post the dosing on the 2nd page? I'd be curious what it is, and from that, I can convert it into horse paste :D
132   joshuatrio   2021 Sep 3, 1:31pm  

richwicks says
joshuatrio says
My dr is on the ivermectin train. Just got this email from here as they decided on their covid protocol:



I use a self-pay membership option, where neither myself or the doc is at the mercy of insurance payouts.


Can you post the dosing on the 2nd page? I'd be curious what it is, and from that, I can convert it into horse paste :D


PREVENTION PROTOCOL
lvermectin1 Chronic Prevention
0.2 mg/kg per dose (take with or after a meal) — twice a week for as long
as disease risk is elevated in your community
Post COVID-19 Exposure Prevention2
0.4 mg/kg per dose (take with or after a meal)  — one dose today, repeat
after 48 hours
Vitamin D3 1,000–3,000 IU/day
Vitamin C 500–1,000 mg twice a day
Quercetin 250 mg/day
Zinc 30–40 mg/day (elemental zinc)
Melatonin 6 mg before bedtime (causes drowsiness)
Gargle mouthwash 2 x daily – gargle (do not swallow) antiseptic mouthwash with cetylpyridinium chloride (e.g. ScopeTM, ActTM, CrestTM), ListerineTM with essential oils,
or povidone/iodine 1 % solution as alternative.
EARLY OUTPATIENT PROTOCOL3
lvermectin1
0.4–0.6 mg/kg per dose (take with or after a meal) — one dose daily, take
for 5 days or until recovered
Use upper dose range if:  1) in regions with aggressive variants (e.g. “Delta” variant);
2) treatment started on or after day 5 of symptoms or in pulmonary phase; or
3) multiple comorbidities/risk factors.
Fluvoxamine4 50 mg twice daily for 10–14 days
Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with
more aggressive variants; 3) treatment started on or after day 5 of symptoms or in
pulmonary phase; or 4) numerous comorbidities/risk factors. Avoid if patient is
already on an SSRI.
Nasal/oral rinse 3 x daily – gargle (do not swallow) antiseptic mouthwash with cetylpyridinium chloride (e.g. ScopeTM, ActTM, CrestTM), ListerineTM with essential oils, or
povidone/iodine 1 % solution as alternative. Nasal rinse instructions below.5
Vitamin D3 4,000 IU/day
Vitamin C 500–1,000 mg twice a day
Quercetin 250 mg twice a day
Zinc 100 mg/day (elemental zinc)
Melatonin 10 mg before bedtime (causes drowsiness)
Aspirin 325 mg/day (unless contraindicated)
Pulse Oximeter Monitoring of oxygen saturation is recommended (for instructions see page 2)
133   Robert Sproul   2021 Sep 3, 4:53pm  

The utterly corrupted AMA has issued a no-nonsense proclamation affirming their corruption:

“Use of ivermectin for the prevention and treatment of COVID-19 has been demonstrated to be harmful to patients. Calls to poison control centers due to ivermectin ingestion have increased five-fold from their pre-pandemic baseline. A recent CDC Health Alert Network Advisory (PDF) recommends that health care professionals should counsel patients against use of ivermectin as a treatment for COVID-19, including emphasizing the potentially toxic effects of this drug, including “nausea, vomiting, and diarrhea. Overdoses are associated with hypotension and neurologic effects such as decreased consciousness, confusion, hallucinations, seizures, coma, and death.”

Luckily the pompous old wind-bags at the AMA only represent roughly 30% of American Doctors.
135   AmericanKulak   2021 Sep 3, 6:05pm  

Karloff says
"Water? You mean that liquid that fish use to crap in?"


It's all about framing.
136   Patrick   2021 Sep 3, 6:15pm  

A concept from https://heartiste.org/

That guy needs to get the Nobel Prize for his excellent and accurate explanations.
138   Karloff   2021 Sep 3, 7:03pm  

Robert Sproul says
Calls to poison control centers due to ivermectin ingestion have increased five-fold from their pre-pandemic baseline.

So, increased from "one" to "five" calls?

Robert Sproul says
“nausea, vomiting, and diarrhea. Overdoses are associated with hypotension and neurologic effects such as decreased consciousness, confusion, hallucinations, seizures, coma, and death.”

Sounds like the same effects as drinking too much scotch.
139   porkchopXpress   2021 Sep 3, 7:57pm  

Karloff says
Robert Sproul says
Calls to poison control centers due to ivermectin ingestion have increased five-fold from their pre-pandemic baseline.

So, increased from "one" to "five" calls?
My thought exactly lol. If they wouldn't ban the human version, people wouldn't risk overdosing on the animal form.
140   Shaman   2021 Sep 3, 8:24pm  

https://shop.coolhorse.com/store/product/DURAMECTIN

This link still works as a source of ivermectin. Most others are toast now. Get it while you can!
141   Patrick   2021 Sep 3, 11:54pm  


Dr. Brian Tyson, MD 🇺🇸
@btysonmd
12h
I cannot believe I have to say this:

“If you do not want early treatment for COVID-19, do not ask for it. However, do not prevent others from getting it just because you don’t agree.”

Its not about politics or vaccines. Its about treating sick people!! Let us treat the sick.
6:31 PM · Sep 3, 2021


https://twitter.com/btysonmd/status/1433860282334384130#m

But wait! Maybe if people get early treatment then they won't die. But deaths are needed to keep the fear going, because fear is what keeps people submitting to the jabs and so keep profits up for Pfizer and Moderna. Therefore early treatment will be stopped by the mafia at the CDC/NIH/FDA.

Profits über alles!
142   Rin   2021 Sep 4, 9:44am  

joshuatrio says
PREVENTION PROTOCOL
Quercetin 250 mg/day


Since most ppl use the Quercetin DiHydrate w/ Bromelain, it's too low of a dosage.

If one's not using the Quercetin Phytosome and is taking the Quercetin DiHydrate w/ fish or olive oil, then one needs at minimum, 500 mg per day, if not 1000 mg per day, just as a preventative measure with Zinc, Vitamin D, Vitamin C, and N-Acetyl-Cysteine (a/o R-Lipoic Acid).

Realize, it's not very bioavailable.
143   Rin   2021 Sep 4, 11:37am  

Rin says
Realize, it's not very bioavailable.


Here's what I'm talking about ...

https://patrick.net/post/1340407?0#comment-1780905

Here's another article on the Phytosome version vs the regular one ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418071



That's clearly over 6 hours at peak concentration in vivo which is not bad.
144   GNL   2021 Sep 4, 11:43am  

Rin says
joshuatrio says
PREVENTION PROTOCOL
Quercetin 250 mg/day


Since most ppl use the Quercetin DiHydrate w/ Bromelain, it's too low of a dosage.

If one's not using the Quercetin Phytosome and is taking the Quercetin DiHydrate w/ fish or olive oil, then one needs at minimum, 500 mg per day, if not 1000 mg per day, just as a preventative measure with Zinc, Vitamin D, Vitamin C, and N-Acetyl-Cysteine (a/o R-Lipoic Acid).

Realize, it's not very bioavailable.

Can't find N-Acetyl-Cysteine (a/o R-Lipoic Acid) anywhere.
145   porkchopXpress   2021 Sep 4, 12:18pm  

Rin says
N-Acetyl-Cysteine (a/o R-Lipoic Acid).
Are those two the same?
146   GNL   2021 Sep 4, 12:34pm  

porkchopexpress says
Rin says
N-Acetyl-Cysteine (a/o R-Lipoic Acid).
Are those two the same?

Oh, right. I can't find either of them.
148   porkchopXpress   2021 Sep 4, 12:46pm  

I bought the Thorne R-Lipoic Acid.

Rin - do you recommend taking both NAC and R-lipoic Acid?
149   Rin   2021 Sep 4, 12:54pm  

If you're having a tough time getting to N-Acetyl-Cysteine, you can opt for the base amino acid L-Cysteine, which is NAC's base prior to acetylation.
150   porkchopXpress   2021 Sep 4, 12:59pm  

Rin says
If you're having a tough time getting to N-Acetyl-Cysteine, you can opt for the base amino acid L-Cysteine, which is NAC's base prior to acetylation.
Thanks.

Separate question on your J&J mitigation strategy. They say that adenovirus vaccines have an increased risk of cerebral venous thrombosis (CVT). Does your supplement cocktail prevent that risk because CVT is caused by spike protein production?
151   Rin   2021 Sep 4, 1:29pm  

porkchopexpress says

Separate question on your J&J mitigation strategy. They say that adenovirus vaccines have an increased risk of cerebral venous thrombosis (CVT). Does your supplement cocktail prevent that risk because CVT is caused by spike protein production?


In a nutshell, what that is is a blood clot in the brain, esp on the venous side, which drains the blood from the brain to the rest of the body.

And as for them forming, either the adenovirus/J&J or the mRNA/Pfizer-Moderna can lead to the lining of the arteries & veins forming clots due to the presence of the Spiked protein which forms platelets in-situ. The difference is that much of the J&J proteins will originate from the shoulder's deltoid muscle, whereas the mRNA ones could form just about anywhere, including within the brain itself.

So with that stated, you have several things going on; you have platelet inhibitors with high amounts of Aspirin along with high amounts of Allisure Allicin. But guess what also serves a hand here? ... Yes, Quercetin again

https://pubmed.ncbi.nlm.nih.gov/15613018/

So that's a three pronged Spiked protein platelet de-activator in your system and all of them were present, a full day before the shot.

And then, you have the antiviral defensive play of Zinc, Vitamin C, Quercetin, Allisure Allicin with the glutathione immune enhancing engine of NAC (or L-Cysteine) with R-Lipoic Acid & Vitamin D and what'll happen is that a slew of adenovirus will essentially die upon landing, kinda like paratroopers when machine gunners are stationed at the shoulder's drop zone.
152   Rin   2021 Sep 4, 1:38pm  

Rin says
So that's a three pronged Spiked protein platelet de-activator in your system and all of them were present, a full day before the shot.


I forgot to mention team member no 4, Turmeric, but its anticoagulant properties need more studying.
153   Shaman   2021 Sep 4, 3:25pm  

Rin says
Rin says
So that's a three pronged Spiked protein platelet de-activator in your system and all of them were present, a full day before the shot.


I forgot to mention team member no 4, Turmeric, but its anticoagulant properties need more studying.


I had heard of this use for Turmeric years before the pandemic. An older friend who was diagnosed with pulmonary edema and had a three year death sentence used turmeric to help his lungs recover and wound up surviving much much longer.
154   Ceffer   2021 Sep 4, 7:13pm  

Ivermectin overdose fake news propaganda shut down. "Rolling Stone 'Horse Dewormer' Hit-Piece Debunked After Hospital Says No Ivermectin Overdoses zerohedge.com/covid-19/rolli…"


https://t.me/FirstAmendmentPraetorian/4273
155   Patrick   2021 Sep 4, 11:05pm  


Jim Rogenmoser
@JimRogenmoser
10h
Replying to @RWMaloneMD
MY VERY IMPORTANT QUESTION. Dr. Malone, are the cohort of older people, with comorbidities, close to as safe if they choose (and have access) to the therapeutic protocols (IVM, HCQ, zinc, etc.) instead of the jab?


I'd like to know the answer to that. I suspect it's "yes, absolutely".

But this would devastate hundreds of billions of dollars in Big Pharma revenues, so it's not a question that anyone in research dares to answer. They will never get funding from the mafia-run NIH if they answer in the affirmative.



157   Patrick   2021 Sep 4, 11:40pm  


Thinking About It
@Jorlev_11
4h
Replying to @RWMaloneMD
Doctor who said ER Overwhelmed with Ivermectin Overdoses FULL OF HORSE SHIT. Hospital says he hasn't worked in their ER for over 2 months and they are Not Treating ANY IVM O.D. Cases or IVM Related Cases. Where are the MEDIA RETRACTIONS?


https://twitter.com/Jorlev_11/status/1434336421771419650#m



https://www.newswars.com/rolling-stone-runs-ivermectin-poisoning-hoax-story/

Et tu, Rolling Stone?
158   Patrick   2021 Sep 4, 11:47pm  

https://rescue.substack.com/p/opinion-ivermectin-ii-cons-and-pros?r=nxypy&utm_campaign=patrick.net&utm_medium=patrick.net&utm_source=patrick.net

Ivermectin II: Cons and pros
Florida newspaper editor Matt Walsh gives an Old School journalism lesson to his statewide audience: both sides of a story!
Matt Walsh Sep 3
159   Patrick   2021 Sep 4, 11:50pm  

https://pubmed.ncbi.nlm.nih.gov/32533071/


In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.
161   RWSGFY   2021 Sep 5, 11:31am  

zzyzzx says


In HORSE cells ONLY!!!
164   Patrick   2021 Sep 5, 3:16pm  



Robert W Malone, MD
@RWMaloneMD
9h
For those that don't know, Peru did a massive campaign with ivermectin in last half of 2020. The mortality dropped 14 fold over 3 months. A new president came in - and stopped the campaign. And deaths rose 13 fold over the next month. This figure is from:"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383101/


Abstract
In 2015, the Nobel Committee for Physiology or Medicine, in its only award for treatments of infectious diseases since six decades prior, honoured the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases. Since March 2020, when IVM was first used against a new global scourge, COVID-19, more than 20 randomized clinical trials (RCTs) have tracked such inpatient and outpatient treatments. Six of seven meta-analyses of IVM treatment RCTs reporting in 2021 found notable reductions in COVID-19 fatalities, with a mean 31% relative risk of mortality vs. controls. During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments. Reductions in deaths correlated with the extent of IVM distributions in all 25 states with p < 0.002. Sharp reductions in morbidity using IVM were also observed in two animal models, of SARS-CoV-2 and a related betacoronavirus. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains.
""
165   Patrick   2021 Sep 5, 3:19pm  

https://www.psychoactif.org/forum/uploads/documents/161/74-1_44-95.pdf


Furthermore, by the 27th of February, the results of 42 clinical trials, including
approximately 15,000 patients (both registered and unregistered studies) have been
subjected to a meta-analysis after exclusion of biasing factors. It was found that 83%
showed improvements with early treatment, 51% improved during late-stage
treatment, and there was an 89% prevention of onset rate noted. This confirms the
usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is
estimated that the probability of this comprehensive judgment being a mistake is as
low as 1 in 4 trillion.
166   Patrick   2021 Sep 5, 3:20pm  

Another one:

https://pubmed.ncbi.nlm.nih.gov/34466270/

During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments.
167   Patrick   2021 Sep 5, 4:28pm  

https://aapsonline.org/aaps-letter-to-ama-re-ivermectin-and-covid/


The AMA has taken the startling and unprecedented position that American physicians should immediately stop prescribing, and pharmacists should stop honoring their prescriptions for ivermectin for COVID-19 patients. The AMA is thus contradicting the professional judgment of a very large number of physicians, who are writing about 88,000 prescriptions per week. It also contradicts the Chairman of the Tokyo Medical Association, Haruo Ozaki, who recommended that all doctors in Japan immediately begin using Ivermectin to treat COVID.

AMA claims that ivermectin is dangerous and ineffective despite the safe prescription of billions of doses since 1981, and the mostly favorable results of 63 controlled studies in COVID-19.

AMA does not specify any recommended early treatments, but simply urges face masks, distancing, and vaccination.

Our members would appreciate clarification of the AMA’s stand on the following questions:

What are the criteria for advocating that pharmacists override the judgment of fully qualified physicians who are responsible for individual patients?
What are the criteria for forbidding off-label use of long-approved drugs, which constitute at least 20 percent of all prescriptions?
On what basis does AMA demand use only within a clinical trial for ivermectin, but call for virtually universal vaccination outside of controlled trials, despite FDA warnings of potential cardiac damage in healthy young patients, and no information about long-term effects?
We believe that these questions get to the heart of issues of physician and patient autonomy, as well as scientific principles such as the need for a control group in experiments.

We look forward to your response.


The AMA is corrupt.

« First        Comments 128 - 167 of 629       Last »     Search these comments

Please register to comment:

api   best comments   contact   latest images   memes   one year ago   random   suggestions   gaiste