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Ivermectin


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2021 May 9, 10:24pm   81,832 views  629 comments

by Patrick   ➕follow (61)   💰tip   ignore  

https://sebastianrushworth.com/2021/05/09/update-on-ivermectin-for-covid-19/

Back in January I wrote an article about four randomized controlled trials of ivermectin as a treatment for covid-19 that had at that time released their results to the public. Each of those four trials had promising results, but each was also too small individually to show any meaningful impact on the hard outcomes we really care about, like death. When I meta-analyzed them together however, the results suddenly appeared very impressive. Here’s what that meta-analysis looked like:



It showed a massive 78% reduction in mortality in patients treated with covid-19. Mortality is the hardest of hard end points, which means it’s the hardest for researchers to manipulate and therefore the least open to bias. Either someone’s dead, or they’re alive. End of story.

You would have thought that this strong overall signal of benefit in the midst of a pandemic would have mobilized the powers that be to arrange multiple large randomized trials to confirm these results as quickly as possible, and that the major medical journals would be falling over each other to be the first to publish these studies.

That hasn’t happened.

Rather the opposite, in fact. South Africa has even gone so far as to ban doctors from using ivermectin on covid-19 patients. And as far as I can tell, most of the discussion about ivermectin in mainstream media (and in the medical press) has centred not around its relative merits, but more around how its proponents are clearly deluded tin foil hat wearing crazies who are using social media to manipulate the masses.

In spite of this, trial results have continued to appear. That means we should now be able to conclude with even greater certainty whether or not ivermectin is effective against covid-19. Since there are so many of these trials popping up now, I’ve decided to limit the discussion here only to the ones I’ve been able to find that had at least 150 participants, and that compared ivermectin to placebo (although I’ll add even the smaller trials I’ve found in to the updated meta-analysis at the end).

As before, it appears that rich western countries have very little interest in studying ivermectin as a treatment for covid. The three new trials that had at least 150 participants and compared ivermectin with placebo were conducted in Colombia, Iran, and Argentina. We’ll go through each in turn. ...

What we see is a 62% reduction in the relative risk of dying among covid patients treated with ivermectin. That would mean that ivermectin prevents roughly three out of five covid deaths. The reduction is statistically significant (p-value 0,004). In other words, the weight of evidence supporting ivermectin continues to pile up. It is now far stronger than the evidence that led to widespred use of remdesivir earlier in the pandemic, and the effect is much larger and more important (remdesivir was only ever shown to marginally decrease length of hospital stay, it was never shown to have any effect on risk of dying).

I understand why pharmaceutical companies don’t like ivermectin. It’s a cheap generic drug. Even Merck, the company that invented ivermectin, is doing it’s best to destroy the drug’s reputation at the moment. This can only be explained by the fact that Merck is currently developing two expensive new covid drugs, and doesn’t want an off-patent drug, which it can no longer make any profit from, competing with them.

The only reason I can think to understand why the broader medical establishment, however, is still so anti-ivermectin is that these studies have all been done outside the rich west. Apparently doctors and scientists outside North America and Western Europe can’t be trusted, unless they’re saying things that are in line with our pre-conceived notions.


And HCQ falls into that same bucket. Even worse - to admit HCQ works would be to admit Trump was right about something.

Liberals would rather that millions die than that Trump be allowed to be right about anything. They hate Trump more than they love their fellow humans.

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157   Patrick   2021 Sep 4, 11:40pm  


Thinking About It
@Jorlev_11
4h
Replying to @RWMaloneMD
Doctor who said ER Overwhelmed with Ivermectin Overdoses FULL OF HORSE SHIT. Hospital says he hasn't worked in their ER for over 2 months and they are Not Treating ANY IVM O.D. Cases or IVM Related Cases. Where are the MEDIA RETRACTIONS?


https://twitter.com/Jorlev_11/status/1434336421771419650#m



https://www.newswars.com/rolling-stone-runs-ivermectin-poisoning-hoax-story/

Et tu, Rolling Stone?
158   Patrick   2021 Sep 4, 11:47pm  

https://rescue.substack.com/p/opinion-ivermectin-ii-cons-and-pros?r=nxypy&utm_campaign=patrick.net&utm_medium=patrick.net&utm_source=patrick.net

Ivermectin II: Cons and pros
Florida newspaper editor Matt Walsh gives an Old School journalism lesson to his statewide audience: both sides of a story!
Matt Walsh Sep 3
159   Patrick   2021 Sep 4, 11:50pm  

https://pubmed.ncbi.nlm.nih.gov/32533071/


In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.
161   RWSGFY   2021 Sep 5, 11:31am  

zzyzzx says


In HORSE cells ONLY!!!
164   Patrick   2021 Sep 5, 3:16pm  



Robert W Malone, MD
@RWMaloneMD
9h
For those that don't know, Peru did a massive campaign with ivermectin in last half of 2020. The mortality dropped 14 fold over 3 months. A new president came in - and stopped the campaign. And deaths rose 13 fold over the next month. This figure is from:"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383101/


Abstract
In 2015, the Nobel Committee for Physiology or Medicine, in its only award for treatments of infectious diseases since six decades prior, honoured the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases. Since March 2020, when IVM was first used against a new global scourge, COVID-19, more than 20 randomized clinical trials (RCTs) have tracked such inpatient and outpatient treatments. Six of seven meta-analyses of IVM treatment RCTs reporting in 2021 found notable reductions in COVID-19 fatalities, with a mean 31% relative risk of mortality vs. controls. During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments. Reductions in deaths correlated with the extent of IVM distributions in all 25 states with p < 0.002. Sharp reductions in morbidity using IVM were also observed in two animal models, of SARS-CoV-2 and a related betacoronavirus. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains.
""
165   Patrick   2021 Sep 5, 3:19pm  

https://www.psychoactif.org/forum/uploads/documents/161/74-1_44-95.pdf


Furthermore, by the 27th of February, the results of 42 clinical trials, including
approximately 15,000 patients (both registered and unregistered studies) have been
subjected to a meta-analysis after exclusion of biasing factors. It was found that 83%
showed improvements with early treatment, 51% improved during late-stage
treatment, and there was an 89% prevention of onset rate noted. This confirms the
usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is
estimated that the probability of this comprehensive judgment being a mistake is as
low as 1 in 4 trillion.
166   Patrick   2021 Sep 5, 3:20pm  

Another one:

https://pubmed.ncbi.nlm.nih.gov/34466270/

During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments.
167   Patrick   2021 Sep 5, 4:28pm  

https://aapsonline.org/aaps-letter-to-ama-re-ivermectin-and-covid/


The AMA has taken the startling and unprecedented position that American physicians should immediately stop prescribing, and pharmacists should stop honoring their prescriptions for ivermectin for COVID-19 patients. The AMA is thus contradicting the professional judgment of a very large number of physicians, who are writing about 88,000 prescriptions per week. It also contradicts the Chairman of the Tokyo Medical Association, Haruo Ozaki, who recommended that all doctors in Japan immediately begin using Ivermectin to treat COVID.

AMA claims that ivermectin is dangerous and ineffective despite the safe prescription of billions of doses since 1981, and the mostly favorable results of 63 controlled studies in COVID-19.

AMA does not specify any recommended early treatments, but simply urges face masks, distancing, and vaccination.

Our members would appreciate clarification of the AMA’s stand on the following questions:

What are the criteria for advocating that pharmacists override the judgment of fully qualified physicians who are responsible for individual patients?
What are the criteria for forbidding off-label use of long-approved drugs, which constitute at least 20 percent of all prescriptions?
On what basis does AMA demand use only within a clinical trial for ivermectin, but call for virtually universal vaccination outside of controlled trials, despite FDA warnings of potential cardiac damage in healthy young patients, and no information about long-term effects?
We believe that these questions get to the heart of issues of physician and patient autonomy, as well as scientific principles such as the need for a control group in experiments.

We look forward to your response.


The AMA is corrupt.
168   Patrick   2021 Sep 5, 4:37pm  

Patrick says
Chairman of the Tokyo Medical Association, Haruo Ozaki, who recommended that all doctors in Japan immediately begin using Ivermectin to treat COVID.


Trying to confirm this by translating https://www.yomiuri.co.jp/choken/kijironko/cknews/20210818-OYT8T50030/ with https://translate.yandex.com/translate


"Just the other day,in India Corona infection treatment guidelines determine the All India Medical University (All India Institute of Medical Sciences/AIIMS) study group, the campaign for the prevention investigated the effect papers as possible. According to it, about 3900 people of health care workers(employees and students)to the subject,ivermectin per 1 kg of body weight per 0. 3 Milli・G to 3-day intervals 2 times group that was administered, 1 time only group that was administered,the administration did not group consisting of three groups divided into clinical trials as a result,campaign 2 times administered in person, the new Corona infection was 83%reduction in the other. Thesis for world-class research groups from very reliable"


But the translation is pretty bad.
169   Patrick   2021 Sep 5, 4:39pm  

C W
@pablovspeanut
Sep 4
Replying to @Dmdufy @joerogan
I’ve been in medicine for about 14 years now. I’ve never seen an adverse reaction to ivermectin or hydroxychloroquin. So on the safety scale both are most likely much safer than Benadryl, ibuprofen, Tylenol, alcohol, shellfish, and most antibiotics that we often use
2:08 PM · Sep 4, 2021


https://twitter.com/pablovspeanut/status/1434156527871352832#m
171   Patrick   2021 Sep 5, 4:41pm  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/


Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.


Truly a wonder drug if it cures some cancers as well as parasites and some viruses.
173   Patrick   2021 Sep 5, 7:18pm  




U.S.—After several successful rounds of trials and a quick overnight approval from the FDA, Pfizer proudly announced they will be releasing a brand new, never-before-seen COVID drug "Pfivermectin."

"It's important to understand that this drug is nothing like Ivermectin, even though Pfivermectin rhymes with Ivermectin and it pretty much does the exact same thing," said Pfizer CEO Hans Pfizer. "Everyone knows Ivermectin is a widely discredited horse drug, and ours is not. Very important distinction there."

Experts say that taking two doses of Pfivermectin every day at the first sign of COVID symptoms could lessen the severity and duration of the infection. Ivermectin will do the same thing, except it may also turn you into a horse and make everyone laugh at you. Not good!

A Pfizer spokesman also confirmed that their drug will be approximately 30,000% more expensive than Ivermectin.

"Don't worry about the cost," said the spokesman. "The government will cover the cost. Besides, that's a small price to pay to not turn into a horse!"
174   Ceffer   2021 Sep 5, 8:26pm  

LOL! Alex Jones takes horse ivermectin. He turns into a democrat.
Looks like he took a good bit. I took less than half that much on three different days. Yeah, the apple stuff still tastes crappy and bitter.
175   Onvacation   2021 Sep 6, 9:45am  

Onvacation says
Calling Dr.

When (if) I get my Ivermectin when and if and how much and how often should I take these little pills.




I understand any advise you give me is not from a licensed doctor, (who the fuck wants to listen to those murderous fucks), and will take full responsibility for any decisions I make.

Thanks

Looks like my order was canceled.

I received an email saying I would get tracking info and then nothing.

I checked my PayPal account and there is no record that I was ever billed.

Probably too late to get the horse paste now that it has been labeled as a dangerous drug.
176   komputodo   2021 Sep 6, 2:07pm  


In Mexico...$4 with 4 - 6mg pills
177   GNL   2021 Sep 6, 3:09pm  

komputodo says

In Mexico...$4 with 4 - 6mg pills

Do you have a purchase link?
178   RWSGFY   2021 Sep 6, 3:16pm  

WineHorror1 says
komputodo says

In Mexico...$4 with 4 - 6mg pills

Do you have a purchase link?


He drove to Tijuana, methinks.
179   komputodo   2021 Sep 6, 7:40pm  

WineHorror1 says
Do you have a purchase link?

No...I walked into the Farmacia Similares and bought them over the counter. It reminds me of the old narrative.., the rest of the world is envious of our "freedoms".
180   komputodo   2021 Sep 6, 7:41pm  

FuckCCP89 says
He drove to Tijuana, methinks.

In Tijuana they probably charge the gringos at least triple...LOL
181   Robert Sproul   2021 Sep 6, 9:13pm  

Pierre Kory, MD MPA
@PierreKory
·
2h
Everything I’ve learned in the pandemic, everything I’ve fought for, fought against & and called attention to.. is perfectly described in this article. An education of a lifetime, should be taught to every high school, college or med student in the land.

https://www.thedesertreview.com/opinion/columnists/the-great-ivermectin-deworming-hoax/article_19b8f2a6-0f29-11ec-94c1-4725bf4978c6.html
185   Patrick   2021 Sep 6, 11:36pm  

https://www.yourobserver.com/article/the-battle-for-ivermectin

AUG. 18, 2021 2 weeks ago The battle for ivermectin
You need to read this magazine story. An old-school reporter shines light on a miracle drug and efforts to quash it.
by: Matt Walsh Editor & CEO
We are connecting you this week to an amazing, extraordinary story of a miracle drug that is “the most powerful COVID-19 killer known to science.”

You may have heard of it: ivermectin.

Ivermectin use in Florida

Are doctors and hospitals in Florida using ivermectin to treat COVID-19?

It appears the numbers are few. Doctors repeatedly have told journalist Michael Capuzzo the pressure against its use from the medical establishment and government agencies is unprecedented.

Nonetheless, cardiologist Dr. Bruce Boros, who operates three clinics in the Florida Keys, was among the first Florida physicians to surface as a prescriber of ivermectin.

Boros told the Miami Herald he had prescribed it as early as spring 2020 and that more than a dozen of his COVID-19 patients recovered after taking the drug.

In Broward County, Dr. Jean-Jacques Rajter, a Fort Lauderdale pulmonologist, also began prescribing ivermectin in April 2020 with successful outcomes. Soon after, the five-hospital Broward Health System approved the drug for use, one of the first and few hospital groups in Florida to do so.

When we polled the six hospitals in Sarasota and Manatee counties on whether they are allowing doctors to prescribe ivermectin, three hospitals responded before deadline:

Neither Blake Hospital in Bradenton nor Doctors Hospital in Sarasota, both owned by HCA Healthcare, is allowing the use of ivermectin.

“Ivermectin is not approved by the FDA for use in treating COVID-19 and has not been shown effective,” wrote Dr. Mitchell Rubinstein, Blake’s chief medical officer. “The FDA.gov website advises against using ivermectin.” ...

For information on ivermectin
FLCCC.net: The website of the Front Line COVID-19 Critical Care Alliance. It is teeming with information about ivermectin and treatments for COVID-19.
Journalists Michael and Teresa Capuzzo have started a new publication on Substack.com called RESCUE, independent reporting on the world’s best COVID-19 doctors and treatments. To get it delivered free to your inbox, contact them at Rescue@substack.com .

Dr. Paul Marik, famous in world medical circles, the second-most published critical care doctor in the history of medicine, told a former colleague of mine and friend, journalist Michael Capuzzo, if ivermectin “were universally distributed at a dose that costs 10 American cents in India and about the cost of a Big Mac in the U.S., ivermectin would save countless lives, crush variants, eliminate the need for endless big pharma booster shots and end the pandemic all over the world.”

That sounds like over-the-top, not-to-be-believed hype. But it’s not.

If you do anything today, or this week, you must read Capuzzo’s story, “The Drug That Cracked COVID,” which was published in the May edition of his and wife Teresa’s Pennsylvania magazine, Mountain Home.


https://cdn.digitalobservermedia.com/yourobserver.com/pdfs/The-Drug-that-Cracked-Covid-by-Michael-Capuzzo.pdf
187   Patrick   2021 Sep 7, 9:42am  

https://spectatorworld.com/topic/ivermectin-horse-skeptics-joe-rogan-covid/

The ivermectin skeptics
Horse dewormer or miracle drug?

September 5, 2021 | 10:58 am

... Pfizer had the first vaccine ready to go before the 2020 election, but selflessly waited until just after the election to make the announcement. They, and the other drug companies in on Operation Warp Speed, have been playing the opening bars of Pink Floyd’s song ‘Money’ nonstop at corporate headquarters ever since. Everyone must be vaccinated, twice (plus boosters) at government (i.e. taxpayer) expense immediately and forever. ...

He showed me a few boxes of ivermectin, told me it was probably an effective therapeutic but it had some serious disadvantages, chief among them is that it was very cheap, and therefore was unsupported by Big Pharma. Consequently, the experts looked down their noses at it, so far down that the politicians, who like the contributions they get from drug companies, basically outlawed its use for COVID. If he prescribed it for COVID, he told me, he could lose his license to practice medicine. ...

Was the recovery propter hoc, because of the ivermectin and other agents, or merely post hoc? Who knows?

But I do know this. It is utterly irresponsible for the establishment media machine to to trash ivermectin categorically. NBC, for example, in reporting Rogan’s diagnosis, screamed that he was taking the ‘widely discredited drug ivermectin’.

Discredited by whom? By St Anthony Fauci, maybe, and Big Pharma, for whom the media acts as PR flaks. ...

The current hostility to ivermectin is of a piece with the earlier hostility to hydroxychloroquine: it was cheap, Donald Trump took it, it must be bad. What really is bad are the proliferating health nazis who are sprouting up like mushrooms — toadstools — everywhere. In some places — Australia, for example, they come bearing the police power of the state and are harassing and incarcerating people for going about their everyday lives. It’s ridiculous. COVID, the original and all its variations thus far, is dangerous to a tiny part of the population. For most of us, it is no more (but also no less) dangerous than the flu. Sure, we should wash our hands and if you are vulnerable you should be take measures to isolate yourselves from risky situations. If I were you, I would also consider stocking up on ivermectin and the other items of Joe Rogan’s cocktail.
188   Patrick   2021 Sep 7, 9:49am  

Joe Rogan Criticized As 'Anti-Science' For Surviving COVID


https://babylonbee.com/news/progressives-outraged-as-another-person-recovers-from-covid

Joe Rogan: 'I'm Doing Better But I'm Still A Little Hoarse'
189   mell   2021 Sep 7, 9:56am  

Patrick says
Joe Rogan: 'I'm Doing Better But I'm Still A Little Hoarse'


should read: 'I'm Doing Better But I'm Still A Little Horse(paste)'
192   Patrick   2021 Sep 8, 2:11pm  

Exactly.

The Pfizer-government complex must prevent all cheap and effective cures or their whole EUA lie about the necessity for mandating the jab falls apart.
193   Robert Sproul   2021 Sep 8, 4:48pm  

Extremely well written series on 'mectin. The whole story, worthy of rubbing your favorite loony-horse-paste-lefty's nose in. I'm sending to my old pal who always claims she believes "the science" when she really just believes "the TV".
https://rescue.substack.com/p/the-drug-that-cracked-covid-part
https://rescue.substack.com/p/the-drug-that-cracked-covid-part-ab9
https://rescue.substack.com/p/the-drug-that-cracked-covid-part-0b9
195   Patrick   2021 Sep 10, 10:32am  

https://rescue.substack.com/p/pierre-kory-responds-to-critics-hollywood?token=patrick.net


Pierre Kory Responds to Critics, Hollywood Style

How does this passionate New York City-born liberal like it when he reads The Washington Post headline: “How the right’s ivermectin conspiracy theories led to people buying horse dewormer.” In other words, how does he handle all the horse-#&%@ that has been piled on ivermectin the past couple weeks?

He doesn’t like it. He loves it. “Bring it on!” Kory often tells his 120,000 Twitter followers. Nobody ever debates Kory. Here’s why: Kory’s technical round knockout of Dr. Garegnani.

So he was delighted when Florida newspaper publisher Matt Walsh asked him to respond to a ferocious critic of the newspaper’s ivermectin coverage, a critic with real credentials—a University of Michigan professor—in a Q&A debate. “I’ve never had more fun than answering these questions,” Kory says. “It was like shooting fish in a barrel.” ...

Dr. Pierre Kory responds: 63 positive studies exceed most approved drugs
The most easily quantifiable way to describe the indefensible lack of “approval” for ivermectin in COVID-19 is to note the actual amount of supportive clinical trials evidence in COVID-19, both randomized (31) and observational (32), including more than 26,000 patients with the near majority of all studies finding at least some important benefit with treatment.

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