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Happy New Year🎊Conscientious medical scientists have discovered the key to closing the root cause of cancer🔑CSC
新年喜报🎊良知医学家发现了关闭癌症根源的钥匙🔑CSC

🔥 Support the breakthrough discoveries made by conscientious medical scientists in the fight against cancer
声援良知医学家对抗癌症的突破性发现

When Ivermectin & Fenbendazole Aren't Enough - Part II
Dr. Marik's Game Changer in Targeting Cancer Stem Cells
JUSTUS R. HOPE
DEC 29
∙
PREVIEW

https://open.substack.com/pub/justusrhope/p/when-ivermectin-and-fenbendazole-827

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The Study that Impressed Dr. Marik - “This is a Game Changer”
Cancer stem cells are a major cause of cancer recurrence and spread. Cancer spread through microscopic remnants - termed CSCs or cancer stem cells - is not effectively addressed by chemotherapy, radiation, or surgery.

While surgery may remove macroscopic - or visible - portions of the tumor, it does nothing to target microscopic cancer stem cells. Worse, surgery stimulates these CSCs.

Radiation and chemotherapy also stimulate CSCs. I refer to CSCs as the “roots of cancer.” Cutting or poisoning the visible portions of the tree, such as the limbs and trunk often stimulates the roots to regrow the tree, and this is precisely what we notice in terminal cancers.

From Surviving Cancer, COVID-19 & Disease: The Repurposed Drug Revolution
A repurposed drug like Ivermectin targets cancer stem cells through different pathways, and that is one reason it is so effective in late-stage cancers. Surprisingly Fenbendazole does not have as major an effect against CSCs, but it more than makes up for this by interfering with cancer’s metabolism and by stimulating P53 activity.

Here is what AI says about the relative effect of Ivermectin versus Mebendazole [chemically similar to Fenbendazole]:

Although Ivermectin and Fenbendazole are powerful anti-cancer drugs, one can increase one’s chances of success by targeting more CSC pathways.

However, as Dr. Paul Marik points out in his book, Cancer Care, there are many supplements that can be added to target CSCs including green tea, curcumin, and various vitamins. Here is an excerpt:

“Adding repurposed drugs to attack CSC should be a priority and should be done at the time of initiation of chemotherapy and radiation therapy. (13) Common repurposed drugs that can attack CSC include:

green tea extract,
melatonin,
vitamin D3,
metformin,
curcumin,
statins (atorvastatin),
berberine,
mebendazole,
doxycycline,
ivermectin,
resveratrol,
aspirin,
diclofenac phosphodiesterase 5-inhibitors, and
omega-3 fatty acids. "
In my book Surviving Cancer COVID-19 & Disease: The Repurposed Drug Revolution, I highlight the anti-cancer clinical effect of Metformin and, notably, its effect against CSCs.

In discussing this today with Dr. Marik, we reviewed some literature concerning Doxycycline which has strong anti-CSC activity.

Recently, I published a Substack concerning low-dose Doxycycline and its effect against viruses and bioweapon attacks, aka gain-of-function microbes. However, Doxycycline has powerful activity against cancer cell mitochondria, and this helps it reduce CSC populations. Because only small doses, such as 20 to 40 mg per day, are necessary, it does not harm the beneficial gut bacteria or cause drug resistance.

Moreover, when combined with tiny doses of Azithromycin and Vitamin C, reductions of CSC by 90% are documented.

Dr. Marik noted a similar study that found a 90% reduction in the CSC population by using only Doxycycline and combining it with Vitamin C.

Dr. Marik found what he calls a “game changer” with regard to oral Vitamin C when combined with Doxycycline. Here is why:

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当伊维菌素和芬苯达唑不够用时 - 第二部分
Marik 博士在靶向癌症干细胞方面的游戏规则改变者
贾斯图斯·R·霍普
12月29日
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在应用程序中阅读

给马里克博士留下深刻印象的研究——“这是一个游戏规则改变者”
癌症干细胞是癌症复发和扩散的主要原因。 通过微小残留物（称为 CSC 或癌症干细胞）扩散的癌症无法通过化疗、放疗或手术有效解决。

虽然手术可以切除肉眼可见的肿瘤部分，但它对靶向微观癌症干细胞没有任何作用。 更糟糕的是，手术会刺激这些 CSC。

放疗和化疗也会刺激 CSC。 我将 CSC 称为“癌症的根源”。 砍伐或毒害树木的可见部分，例如四肢和树干，通常会刺激树根重新生长，这正是我们在晚期癌症中注意到的。

来自幸存的癌症、COVID-19 和疾病：重新调整用途的药物革命
像伊维菌素这样的重新利用的药物通过不同的途径靶向癌症干细胞，这就是它对晚期癌症如此有效的原因之一。 令人惊讶的是，芬苯达唑对 CSC 没有那么大的作用，但它通过干扰癌症的新陈代谢和刺激 P53 活性来弥补这一点。

以下是人工智能对伊维菌素与甲苯达唑（化学性质与芬苯达唑相似）的相对效果的评价：

尽管伊维菌素和芬苯达唑是强效抗癌药物，但可以通过针对更多 CSC 途径来增加成功的机会。

然而，正如 Paul Marik 博士在他的《癌症护理》一书中指出的那样，有许多补充剂可以针对癌症干细胞添加，包括绿茶、姜黄素和各种维生素。 以下是摘录：

“添加新用途药物来攻击 CSC 应该是一个优先事项，并且应该在开始化疗和放疗时进行。 (13) 常见的可攻击 CSC 的再利用药物包括：

绿茶提取物，
褪黑激素，
维生素D3，
二甲双胍，
姜黄素,
他汀类药物（阿托伐他汀），
小檗碱,
甲苯咪唑，
多西环素，
伊维菌素，
白藜芦醇，
阿司匹林，
双氯芬酸磷酸二酯酶5抑制剂，和
omega-3 脂肪酸。 ”
在我的书《生存癌症 COVID-19 与疾病：重新利用的药物革命》中，我强调了二甲双胍的抗癌临床效果，特别是它对 CSC 的作用。

今天与 Marik 博士讨论这个问题时，我们回顾了一些有关强力霉素的文献，强力霉素具有很强的抗 CSC 活性。

最近，我发表了一个关于低剂量多西环素及其对抗病毒和生物武器攻击（又名功能获得性微生物）的效果的子堆栈。 然而，多西环素对癌细胞线粒体具有强大的活性，这有助于减少 CSC 数量。 由于只需小剂量，例如每天 20 至 40 毫克，因此不会损害有益的肠道细菌或引起耐药性。

此外，据记录，当与小剂量的阿奇霉素和维生素 C 结合使用时，CSC 减少了 90%。

Marik 博士指出，一项类似的研究发现，仅使用强力霉素并与维生素 C 结合使用，CSC 数量可减少 90%。

Marik 博士发现，口服维生素 C 与多西环素结合使用时，他称之为“游戏规则改变者”。 原因如下：

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which drug targets cancer stem cells , ivermectin or mebendazole ? Ivermectin Ivermectin has been demonstrated to preferentially inhibit cancer stem - like cells in various cancers , particularly breast cancer . It achieves this by downregulating the expression of key ' stemness ' genes such as nanog , oct - 4 , and sox - 2 , which are crucial for maintaining the properties of CSCs 1. Studies indicate that ivermectin can effectively reduce the viability of CSC - enriched populations compared to total cell populations , suggesting a targeted approach towards these resilient cell types 13. Additionally , ivermectin has been shown to induce apoptosis and autophagy in cancer cells , further contributing to its anticancer effects 49 . Mebendazole Mebendazole also targets CSCs and has been noted for its potent antiproliferative effects across various cancer cell lines , including gastric and leukemia cells . It works by disrupting microtubule function , leading to cell cycle arrest and apoptosis 2 6 . Mebendazole has demonstrated significant efficacy in reducing tumor growth and metastasis in preclinical studies , particularly in models of triple - negative breast cancer ( TNBC ) where it decreases integrin ẞ4 expression , a marker associated with CSC properties 8. Furthermore , mebendazole has shown promise in combination therapies , enhancing the effects of other chemotherapeutic agents 2 . Conclusion Both ivermectin and mebendazole exhibit capabilities to target cancer stem cells , but ivermectin appears to have a more pronounced effect on CSCs in breast cancer specifically . In contrast , mebendazole shows broader applications across various cancers with strong antiproliferative effects . The choice between the two may depend on the specific type of cancer being treated and the desired therapeutic outcomes . 哪种药物针对癌症干细胞，伊维菌素还是甲苯咪唑？ 伊维菌素 伊维菌素已被证明能够优先抑制各种癌症（尤其是乳腺癌）中的癌症干细胞样细胞。 它通过下调关键“干性”基因（如nanog、oct - 4和sox - 2）的表达来实现这一目标，这些基因对于维持CSC的特性至关重要1。研究表明，伊维菌素可以有效降低富含CSC的活力。 细胞群与总细胞群相比，表明针对这些弹性细胞类型的有针对性的方法13。此外，伊维菌素已被证明可以诱导细胞凋亡和自噬 癌细胞，进一步发挥其抗癌作用 49． 甲苯咪唑 甲苯咪唑还针对癌症干细胞，并以其对各种癌细胞系（包括胃癌细胞和白血病细胞）的有效抗增殖作用而闻名。 它通过破坏微管功能发挥作用，导致细胞周期停滞和细胞凋亡 2 6 。 临床前研究表明，甲苯咪唑在减少肿瘤生长和转移方面具有显着功效，特别是在三阴性乳腺癌（TNBC）模型中，它可以降低整合素ẞ4的表达，这是与CSC特性相关的标志物8。此外，甲苯咪唑在联合用药方面也显示出良好的前景。 治疗，增强其他化疗药物的效果 2． 结论伊维菌素和甲苯咪唑均具有靶向肿瘤干细胞的能力，但伊维菌素似乎对乳腺癌中的CSCs具有更显着的作用。 相比之下，甲苯咪唑在各种癌症中显示出更广泛的应用，具有很强的抗增殖作用。 两者之间的选择可能取决于所治疗的癌症的具体类型和所需的治疗结果。

图片资料翻译：2

Research Paper Volume 11 , Issue 8 pp …Doxycycline , Azithromycin and Vitamin C ( DAV ) : A potent combination therapy for targeting mitochondria and eradicating cancer stem cells ( CSCs ) Marco Fiorillo 1,2 , Fanni Tóth¹ , Federica Sotgia¹ , Michael P. Lisanti¹ 1 Translational Medicine , School of Environment and Life Sciences , Biomedical Research Centre ( BRC ) , University of Salford , Greater Manchester , M5 4WT , United Kingdom 2 The Department of Pharmacy , Health and Nutritional Sciences , The University of Calabria , Cosenza , Italy Received : February 13 , 2019 Published : April 19 , 2019 … 101905 How to Cite Accepted : April 3 , 2019 研究论文第 11 卷，第 8 期，第 2…页 93 强力霉素、阿奇霉素和维生素 C (DAV)：一种针对线粒体和根除癌症干细胞 (CSC) 的有效联合疗法 Marco Fiorillo 1,2、Fanni Tóth1、Federica Sotgia1、Michael P. Lisanti 1 环境与生命科学学院转化医学 ，生物医学研究中心 (BRC)，索尔福德大学，大曼彻斯特，M5 4WT，英国 2 卡拉布里亚大学药学、健康和营养科学系，意大利科森扎 收稿日期：2019 年 2 月 13 日 发布日期：4 月 19 日， 如何引用 接受日期：2019 年 4 月 3

When Ivermectin & Fenbendazole Aren't Enough
Fine Tuning Cancer Care with Thomas Seyfried & Kevin Hennings
JUSTUS R. HOPE
DEC 23
∙
PREVIEW

https://open.substack.com/pub/justusrhope/p/when-ivermectin-and-fenbendazole

And Seyfried explains that the standard treatments can work in concert with the preferred metabolic therapies, so long as people use them strategically. He notes chemotherapy works better during a state of fasting where lower doses can be applied.
Dr. Seyfried also explained that most oncologists did not have a basic understanding of cancer biology and, hence, are unable to explain the best diet and repurposed drug strategies to patients. Mainstream medicine remains stuck in the belief that cancer arises from genetic mutations, but the fact of the matter is that it is a disease of metabolism brought on by defective mitochondria.
When one understands this, he explains, one can make accurate, informed decisions about what diet and lifestyle to pursue and whether or not one wishes to take the risk of getting cancer by engaging in a risky lifestyle of indulging in 24/7 eating of sweets and processed foods with little or no overnight fasting.
The problem is that very few patients and almost no mainstream physicians understand this. Therefore, the average person has no clue what lifestyle causes cancer, and what lifestyle prevents it. The typical cancer patient also has no clue - other than what his similarly ignorant oncologist suggests - what is best to treat the disease.
And Big Pharma & Big Foods, working in tandem through our beloved guardian - that blessed FDA - wish to keep it that way.
By keeping both consumers and their doctors in the dark, they can keep the profits rolling in. As Calley and Casey Means explained to Tucker Carlson, this may be designed to maximize corporate profits, but it is also a recipe for sickness.
Fortunately, all of this is about to change under a Health & Human Services Department directed by someone in the know, someone more enlightened about disease, like Robert F. Kennedy Jr. And he will be working closely with enlightened experts like Calley Means, Casey Means, Pierre Kory, and a host of others.
But I digress.
There is a reason many readers are relying mainly on Ivermectin & Fenbendazole cocktails and not finding quite the rapid benefits in their cancers they had hoped.
And it is not because their doses aren’t high enough.
It is because they are missing the point of what drives cancer. Cancer is unregulated cell growth. According to the Metabolic Theory of Cancer - which was aptly described by Dr. Pierre Kory - cancer uses only two types of fuel to grow.
The first is sugar which can be in the form of glucose, fructose, or related compounds. The second is glutamine. According to Dr. Seyfried and his laboratory studies, cancer has defective mitochondria and cannot metabolize ketone bodies. Instead, cancer relies on ancient fermentation pathways.
The solution, Seyfried explains, is to starve cancer while feeding our human bodies, which can metabolize ketones. Ketones are produced when we consume fat or fast, and proteins can also be used as long as we avoid glutamine or take drugs that block its breakdown. Seyfried uses an experimental compound called DON to block glutamine in his studies.
However, certain other drugs, like Ivermectin and Mebendazole [chemically related to Fenbendazole], also interfere with cancer metabolism.
Dr. Seyfried also dispels the notion that cancer is a parasitic disease and, therefore, responds to antiparasitic drugs. Seyfried clarifies that both cancer and parasitic worms depend on fermentation metabolism, thus drugs that block this tend to kill both.
The bottom line is this:
One must actively make every effort to cut off their cancer’s sugar and glutamine fuel supply if they expect to beat it. This means that in addition to repurposed drugs, one must make diet and lifestyle changes.
It is fairly simple to know if you are consuming sugar or not. It is entirely not simple to stop eating it if you are addicted. However, if your life depends upon avoiding sugar, it is easy to keep it out of the house and, hence, unavailable. Don’t forget to look for hidden sugars in sauces, or hidden corn syrup contained in soups and crackers.
And don’t ignore the double whammy of glyphosate-loaded poisons hidden in the cancer-fueling high fructose corn syrup. This means avoiding anything containing corn or corn syrup, soy, or soybean oil, and much of the wheat unless certified organic.
Avoiding glutamine is much more problematic as it is the most abundant amino acid, a breakdown product of protein. Glutamine is even made by your body even if you swear off protein. Water fasts are the most effective at starving cancer; however, the second-best option is a ketogenic diet using intermittent or overnight fasting. Kevin Hennings beat his Stage 4 Colon Cancer using a Fenbendazole Cocktail and now has adopted a 20-hour daily overnight fasting regimen against a backdrop of a ketogenic diet. 塞弗里德解释说，只要人们有策略地使用标准疗法，就可以与首选的代谢疗法协同工作。 他指出，化疗在禁食状态下效果更好，可以使用较低的剂量。
Seyfried 博士还解释说，大多数肿瘤学家对癌症生物学没有基本了解，因此无法向患者解释最佳饮食和重新调整药物策略。 主流医学仍然坚信癌症是由基因突变引起的，但事实是，这是一种由线粒体缺陷引起的新陈代谢疾病。
他解释说，当人们理解这一点时，人们就可以做出准确、明智的决定，决定要追求什么饮食和生活方式，以及是否愿意冒着患癌症的风险，采取一种24/7都吃甜食的危险生活方式。 和加工食品，很少或根本不禁食过夜。
问题是很少有患者和几乎没有主流医生明白这一点。 因此，普通人不知道什么生活方式会导致癌症，什么生活方式可以预防癌症。 典型的癌症患者也没有任何线索——除了他同样无知的肿瘤学家的建议——什么是最好的治疗这种疾病的方法。
大型制药公司和大型食品公司通过我们敬爱的守护者——神圣的 FDA——携手合作，希望保持这种状态。
通过让消费者和他们的医生都蒙在鼓里，他们可以让利润滚滚而来。正如卡利和凯西·米恩斯向塔克·卡尔森解释的那样，这可能是为了最大限度地提高公司利润，但它也是导致疾病的根源。
幸运的是，在卫生与公众服务部的领导下，所有这一切都将发生改变，该部门的领导者是知情人士，对疾病更加开明的人，例如小罗伯特·F·肯尼迪。他将与卡利·米恩斯、凯西等开明的专家密切合作。 米恩斯、皮埃尔·科里和其他许多人。
但我离题了。
许多读者主要依赖伊维菌素和芬苯达唑混合物，却没有发现他们所希望的对癌症有快速的疗效，这是有原因的。
这并不是因为它们的剂量不够高。
这是因为他们没有抓住癌症的致病因素。 癌症是不受控制的细胞生长。 根据癌症代谢理论（皮埃尔·科里博士恰当地描述了这一理论），癌症仅使用两种类型的燃料来生长。
第一种是糖，可以是葡萄糖、果糖或相关化合物的形式。 第二种是谷氨酰胺。 根据 Seyfried 博士和他的实验室研究，癌症的线粒体有缺陷，不能代谢酮体。 相反，癌症依赖于古老的发酵途径。
塞弗里德解释说，解决方案是在给我们的人体提供食物的同时，让癌症挨饿，因为人体可以代谢酮。 当我们消耗脂肪或禁食时会产生酮，只要我们避免谷氨酰胺或服用阻止其分解的药物，也可以使用蛋白质。 Seyfried 在他的研究中使用一种名为 DON 的实验化合物来阻断谷氨酰胺。
然而，某些其他药物，如伊维菌素和甲苯达唑[与芬苯达唑化学相关]，也会干扰癌症代谢。
塞弗里德博士还驳斥了这样的观点：癌症是一种寄生虫病，因此对抗寄生虫药物有反应。 塞弗里德澄清说，癌症和寄生虫都依赖于发酵代谢，因此阻止这种代谢的药物往往会杀死两者。
底线是这样的：
如果人们希望战胜癌症，就必须积极尽一切努力切断癌症的糖和谷氨酰胺燃料供应。 这意味着除了重新调整药物用途外，还必须改变饮食和生活方式。
知道您是否食用糖是相当简单的。 如果你吃上瘾了，想要戒掉它绝对不是一件容易的事。 然而，如果你的生活依赖于避免吃糖，那么很容易将其拒之门外，因此无法获得。 不要忘记寻找酱汁中隐藏的糖，或汤和饼干中隐藏的玉米糖浆。
并且不要忽视致癌高果糖玉米糖浆中隐藏的草甘膦毒物的双重打击。 这意味着避免任何含有玉米或玉米糖浆、大豆或大豆油以及大部分小麦的食品，除非经过有机认证。
避免谷氨酰胺的问题要大得多，因为它是最丰富的氨基酸，是蛋白质的分解产物。 即使您发誓不吃蛋白质，谷氨酰胺甚至是由您的身体产生的。 禁水对于饥饿癌症最有效。 然而，第二好的选择是间歇性禁食或隔夜禁食的生酮饮食。 Kevin Hennings 使用芬苯达唑鸡尾酒战胜了第四期结肠癌，现在在生酮饮食的背景下采用了每天 20 小时的隔夜禁食疗法。

Hennings has taken up the gauntlet of Joe Tippens in advocating the Fenbendazole Cocktail, and he has inspired a new generation of repurposed drug-using cancer patients. However, what was perhaps lacking in the Joe Tippens approach was the necessary diet and lifestyle changes that Dr. Seyfried’s studies have revealed.
Kevin Hennings has revised his enormously successful cancer treatment protocol - which saved his life - which now includes Berberine, Ivermectin, and DMSO. Here is the full revised Kevin Hennings repurposed drug protocol, including dosages as of July 3, 2024: 亨宁斯接受了乔·蒂彭斯的挑战，倡导芬苯达唑鸡尾酒，他激励了新一代重新利用药物的癌症患者。 然而，乔·蒂彭斯的方法中可能缺少的是塞弗里德博士的研究揭示的必要的饮食和生活方式的改变。
凯文·亨宁斯 (Kevin Hennings) 修改了他非常成功的癌症治疗方案 - 这挽救了他的生命 - 现在包括小檗碱（枸杞子）、伊维菌素和 DMSO。 以下是完整修订的 Kevin Hennings 重新调整药物方案，包括截至 2024 年 7 月 3 日的剂量：