Recent large Jama study on alcohol/wine
2026 Jan 19, 10:16am 177 views 14 comments
by mell follow (12)
"Wine preference and drinking only during meals were associated with lower all-cause mortality only in participants with health-related risk factors (wine preference: HR, 0.92; 95% CI, 0.87-0.97; drinking only during meals: HR, 0.93; 95% CI, 0.89-0.97), as well as in participants with socioeconomic risk factors (wine preference: HR, 0.84; 95% CI, 0.78-0.90; drinking only during meals: HR, 0.83; 95% CI, 0.78-0.89) (Table 3). Drinking only during meals was also associated with lower cancer mortality in participants with health-related risk factors (HR, 0.92; 95% CI, 0.86-0.99) or socioeconomic risk factors (HR, 0.85; 95% CI, 0.78-0.94) (Table 3). Furthermore, in individuals with socioeconomic risk factors, wine preference was associated with lower cancer mortality (HR, 0.89; 95% CI, 0.80-0.99) and drinking only during meals with lower CVD mortality (HR, 0.86; 95% CI, 0.75-1.00) (Table 3). Adhering to both drinking patterns was associated with lower all-cause, cancer, and CVD mortality in drinkers with health-related or socioeconomic risk factors, and to a lesser extent, with lower all-cause death in drinkers without health-related risk factors (eTable 2 in Supplement 1). Importantly, wine preference and drinking during meals modified the association of mean alcohol intake with mortality: the excess risk of all-cause, cancer, and CVD death for high-risk drinkers, of all-cause and cancer death for moderate-risk drinkers, and of cancer death for low-risk drinkers vs occasional drinkers was attenuated and even lost among individuals with these drinking patterns (Table 4). Analyses excluding participants with prevalent cancer at baseline for cancer mortality, or those with prevalent CVD at baseline for CVD mortality showed consistent results (eTables 3-6 in Supplement 1)."
Comments 1 - 14 of 14 Search these comments
1
mell
2026 Jan 19, 10:17am
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822215
They're trying to bury the positive results in the conclusion, but it's no working and been picked up by several outlets.
They're trying to bury the positive results in the conclusion, but it's no working and been picked up by several outlets.
2
Ceffer
2026 Jan 19, 10:26am
Ceffer
2026 Jan 19, 10:26am
Gee, I wonder who financed this 'study'? They are pumped into the infosphere on a regular basis. Did it ever occur that people should seek positive health benefits from substances that are not addictive or from studies not financed by the industries and sales collectives that profit from the addictions?
"Heroin prevents cancer and Alzheimer's! Long term studies from the same journals that brought you Covid! Special unbiased reports! We guarantee that our data mining is free of all prejudice! Enjoy your heroin!"
"Heroin prevents cancer and Alzheimer's! Long term studies from the same journals that brought you Covid! Special unbiased reports! We guarantee that our data mining is free of all prejudice! Enjoy your heroin!"
3
mell
2026 Jan 19, 10:33am
Sola dosis facet venenum is true for 80% of substances. Alcohol consumption has declined rapidly in the US, there is no widespread problem (if you exclude AWFLs) as opposed to fentanyl and other hard ultra-addctive drugs. People drinking moderately should expect no worse health outcomes, if at all slightly better. That's all. We all know excessive alcohol consumption is bad for ones health, potentially fatal (so is excessive Turmeric consumption, one of the best natural anti-inflammatory condiments).
4
Ceffer
2026 Jan 19, 10:42am
Ceffer
2026 Jan 19, 10:42am
Drink whatever you want. Slosh 'em down in front of your kids at dinner. Just drop the pretense that it has anything to do with 'good health'. Promoting your own habits as 'good health' for the industries and their propagandas is free advertising for them.
I can't count the times people have offered me dope, drink, or cigarettes in the past dozens of years. Users like company and like justification. The vendors are happy to provide the mythologies, even wearing the white coats and stethescopes. Whore doctors and fake scientists are a dime a dozen these days.
I can't count the times people have offered me dope, drink, or cigarettes in the past dozens of years. Users like company and like justification. The vendors are happy to provide the mythologies, even wearing the white coats and stethescopes. Whore doctors and fake scientists are a dime a dozen these days.
5
mell
2026 Jan 19, 11:01am
Ceffer says
I agree with this in the sense that I never pressure anybody to drink, and defend them when others do, but that goes for everything, eating meat (love meat but have zero problems with vegetarians or vegans). Herd mentality is never good. I do object when helpful substances are banned for the lowest common denominator.
Heroin was a great cough suppressant in low doses, then banned, mostly replaced with codeine, another great, of not.better one, which was pulled again in many countries because some abused it. Nowadays if you have a bad cold and want a good night sleep there is no good cough suppressant, standard antihistamines or anticholinergis which have maybe 20% of effectiveness of codeine.
So you come full circle and either liquor yourself up with schnapps or Nyquil which enhances the antihistamines with alcohol.
Drink whatever you want. Slosh 'em down in front of your kids at dinner. Just drop the pretense that it has anything to do with 'good health'. Promoting your own habits as 'good health' for the industries and their propagandas is free advertising for them.
I can't count the times people have offered me dope, drink, or cigarettes in the past dozens of years. Users like company and like justification. The vendors are happy to provide the mythologies, even wearing the white coats and stethescopes. Whore doctors and fake scientists are a dime a dozen these days.
I agree with this in the sense that I never pressure anybody to drink, and defend them when others do, but that goes for everything, eating meat (love meat but have zero problems with vegetarians or vegans). Herd mentality is never good. I do object when helpful substances are banned for the lowest common denominator.
Heroin was a great cough suppressant in low doses, then banned, mostly replaced with codeine, another great, of not.better one, which was pulled again in many countries because some abused it. Nowadays if you have a bad cold and want a good night sleep there is no good cough suppressant, standard antihistamines or anticholinergis which have maybe 20% of effectiveness of codeine.
So you come full circle and either liquor yourself up with schnapps or Nyquil which enhances the antihistamines with alcohol.
6
Ceffer
2026 Jan 19, 11:17am
Ceffer
2026 Jan 19, 11:17am
I don't care who vapes, snorts, smokes, tokes, drinks etc. Do all you want, up to the point that the baleful forces of society or your own compromised health sort you out in one way or another. People who drink/use to excess can usually be avoided, if they don't run you over in a car. Walk around in a brain shrinking haze. Drop the dishes while cleaning the kitchen.
JUST CUT THE CRAP THAT IT IS GOOD FOR HEALTH.
It just feels good and you want to do it in spite of. Fake studies from the vendors reassure you that your use has nothing but benefits and no downsides. It works because these stupid fake studies keep getting promulgated. They profit from your wishful thinking about the stuff.
I just wish ONCE somebody would say "I read this fake study, and it's all bullshit, but I am still going to do what I want to do because it feels good and I am habituated. I will live with the consequences and know that they publish bullshit to massage my need."
JUST CUT THE CRAP THAT IT IS GOOD FOR HEALTH.
It just feels good and you want to do it in spite of. Fake studies from the vendors reassure you that your use has nothing but benefits and no downsides. It works because these stupid fake studies keep getting promulgated. They profit from your wishful thinking about the stuff.
I just wish ONCE somebody would say "I read this fake study, and it's all bullshit, but I am still going to do what I want to do because it feels good and I am habituated. I will live with the consequences and know that they publish bullshit to massage my need."
7
Patrick
2026 Jan 19, 11:18am
Patrick
2026 Jan 19, 11:18am
I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.
Was giving me headaches, malaise, and swollen feet.
When I stopped, the problems went away.
I’m pretty sure it was a kind of liver damage.
Was giving me headaches, malaise, and swollen feet.
When I stopped, the problems went away.
I’m pretty sure it was a kind of liver damage.
8
mell
2026 Jan 19, 12:28pm
Ceffer says
The mainstream has heavily turned onto Alcohol though, after turning on cigarettes. I don't smoke, but would love to see a study for people smoking 1-2 cigarettes (natural such as American spirit) a day vs non-smokers and compare longevity/all-cause mortality. If it's so clear cut, why has nobody done it yet? I do know that there are multiple beneficial components in red wine (as well as in other types of spirits) and do not believe based on those facts that light/moderate drinking is bad.
Patrick says
It's pretty potent. Btw. I started the nightly baby aspirin regimen based on new findings I read about. Interestingly the various benefits do not seem to appear on dosages significantly above 81mg, something to do with activating cox1 and 2 pathways vs cox1 only on the low dose.
I just wish ONCE somebody would say "I read this fake study, and it's all bullshit, but I am still going to do what I want to do because it feels good and I am habituated. I will live with the consequences and know that they publish bullshit to massage my need."
The mainstream has heavily turned onto Alcohol though, after turning on cigarettes. I don't smoke, but would love to see a study for people smoking 1-2 cigarettes (natural such as American spirit) a day vs non-smokers and compare longevity/all-cause mortality. If it's so clear cut, why has nobody done it yet? I do know that there are multiple beneficial components in red wine (as well as in other types of spirits) and do not believe based on those facts that light/moderate drinking is bad.
Patrick says
I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.
Was giving me headaches, malaise, and swollen feet.
When I stopped, the problems went away.
I’m pretty sure it was a kind of liver damage.
It's pretty potent. Btw. I started the nightly baby aspirin regimen based on new findings I read about. Interestingly the various benefits do not seem to appear on dosages significantly above 81mg, something to do with activating cox1 and 2 pathways vs cox1 only on the low dose.
9
Blue
2026 Jan 19, 1:00pm
Patrick says
Glad that you recognized and stopped it.
Generally, turmeric is used very sparingly in cooking and is not included in all dishes. A recommended limit is about 1 gram per person per serving, and it shouldn't be consumed daily in my experience.
I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.
Was giving me headaches, malaise, and swollen feet.
When I stopped, the problems went away.
Glad that you recognized and stopped it.
Generally, turmeric is used very sparingly in cooking and is not included in all dishes. A recommended limit is about 1 gram per person per serving, and it shouldn't be consumed daily in my experience.
10
socal2
2026 Jan 19, 1:12pm
I've been taking Turmeric capsules for a couple years now and have had no adverse problems. My lower back and knees have been feeling great with less inflamation and also hope it is helping keep any cancer at bay with my family's history. I was unaware there were any negative health effects other than nausea if you take too much on an empty stomach.
11
mell
2026 Jan 19, 1:22pm
socal2 says
If you take supplements as directed you most likely will never encounter side effects. But there are always people who are sensitive or whose liver cannot break it down, and those who simply take way too much. It's an amazing supplement which you can also cook with. Also look up low dose (baby aspirin) suplementation for significant anti-cancer effects, aside from general anti-inflammatory and heart benefits: https://www.nature.com/articles/s41586-025-08626-7
I've been taking Turmeric capsules for a couple years now and have had no adverse problems. My lower back and knees have been feeling great with less inflamation and also hope it is helping keep any cancer at bay with my family's history. I was unaware there were any negative health effects other than nausea if you take too much on an empty stomach.
If you take supplements as directed you most likely will never encounter side effects. But there are always people who are sensitive or whose liver cannot break it down, and those who simply take way too much. It's an amazing supplement which you can also cook with. Also look up low dose (baby aspirin) suplementation for significant anti-cancer effects, aside from general anti-inflammatory and heart benefits: https://www.nature.com/articles/s41586-025-08626-7
12
goofus
2026 Jan 19, 4:59pm
Patrick says
There have been quite a few reports on adulterated turmeric lately. The mix includes lead chromate, which is also bright yellow, and highly neurotoxic. I hope this wasn’t the case for you.
https://www.sciencedirect.com/science/article/pii/S0048969724051532
I poisoned myself with turmeric and pepper for a couple of months a few years ago, sprinkling that on food at most meals.
Was giving me headaches, malaise, and swollen feet.
When I stopped, the problems went away.
I’m pretty sure it was a kind of liver damage.
There have been quite a few reports on adulterated turmeric lately. The mix includes lead chromate, which is also bright yellow, and highly neurotoxic. I hope this wasn’t the case for you.
https://www.sciencedirect.com/science/article/pii/S0048969724051532
Evidence of turmeric adulteration with lead chromate across South Asia
Highlights
•Pb and Cr concentrations of turmeric across South Asia
•Pb:Cr molar ratio indicates PbCrO4 adulteration versus environmental contamination
•Pb levels >500 times higher than regulatory limit in India, Pakistan, and Nepal
•Projected blood lead levels exceed reference levels by >10-fold due to turmeric
•Spices represent an understudied source of lead poisoning globally
13
HeadSet
2026 Jan 19, 6:18pm
HeadSet
2026 Jan 19, 6:18pm
goofus says
You may be surprised if you check out cinnamon. Most brands have a damaging amount of lead.
https://www.consumerreports.org/health/food-contaminants/high-lead-levels-in-cinnamon-powders-and-spice-mixtures-a4542246475/?msockid=02bc18ca42ef616c1aa60bd443bd6039
The mix includes lead chromate, which is also bright yellow, and highly neurotoxic.
You may be surprised if you check out cinnamon. Most brands have a damaging amount of lead.
https://www.consumerreports.org/health/food-contaminants/high-lead-levels-in-cinnamon-powders-and-spice-mixtures-a4542246475/?msockid=02bc18ca42ef616c1aa60bd443bd6039
14
Patrick
2026 Jan 19, 7:00pm
Patrick
2026 Jan 19, 7:00pm
I later read that some people are just genetically predisposed to liver damage from turmeric and pepper:
https://www.amjmed.com/article/S0002-9343(22)00740-9/fulltext
https://www.amjmed.com/article/S0002-9343(22)00740-9/fulltext
HLA typing demonstrated that 7 patients carried HLA-B*35:01, 2 of whom were homozygous, yielding an allele frequency of 0.450 compared with population controls of 0.056-0.069.
Conclusion
Liver injury due to turmeric appears to be increasing in the United States, perhaps reflecting usage patterns or increased combination with black pepper. Turmeric causes potentially severe liver injury that is typically hepatocellular, with a latency of 1 to 4 months and strong linkage to HLA-B*35:01.
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