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Ivermectin


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2021 May 9, 10:24pm   81,561 views  629 comments

by Patrick   ➕follow (61)   💰tip   ignore  

https://sebastianrushworth.com/2021/05/09/update-on-ivermectin-for-covid-19/

Back in January I wrote an article about four randomized controlled trials of ivermectin as a treatment for covid-19 that had at that time released their results to the public. Each of those four trials had promising results, but each was also too small individually to show any meaningful impact on the hard outcomes we really care about, like death. When I meta-analyzed them together however, the results suddenly appeared very impressive. Here’s what that meta-analysis looked like:



It showed a massive 78% reduction in mortality in patients treated with covid-19. Mortality is the hardest of hard end points, which means it’s the hardest for researchers to manipulate and therefore the least open to bias. Either someone’s dead, or they’re alive. End of story.

You would have thought that this strong overall signal of benefit in the midst of a pandemic would have mobilized the powers that be to arrange multiple large randomized trials to confirm these results as quickly as possible, and that the major medical journals would be falling over each other to be the first to publish these studies.

That hasn’t happened.

Rather the opposite, in fact. South Africa has even gone so far as to ban doctors from using ivermectin on covid-19 patients. And as far as I can tell, most of the discussion about ivermectin in mainstream media (and in the medical press) has centred not around its relative merits, but more around how its proponents are clearly deluded tin foil hat wearing crazies who are using social media to manipulate the masses.

In spite of this, trial results have continued to appear. That means we should now be able to conclude with even greater certainty whether or not ivermectin is effective against covid-19. Since there are so many of these trials popping up now, I’ve decided to limit the discussion here only to the ones I’ve been able to find that had at least 150 participants, and that compared ivermectin to placebo (although I’ll add even the smaller trials I’ve found in to the updated meta-analysis at the end).

As before, it appears that rich western countries have very little interest in studying ivermectin as a treatment for covid. The three new trials that had at least 150 participants and compared ivermectin with placebo were conducted in Colombia, Iran, and Argentina. We’ll go through each in turn. ...

What we see is a 62% reduction in the relative risk of dying among covid patients treated with ivermectin. That would mean that ivermectin prevents roughly three out of five covid deaths. The reduction is statistically significant (p-value 0,004). In other words, the weight of evidence supporting ivermectin continues to pile up. It is now far stronger than the evidence that led to widespred use of remdesivir earlier in the pandemic, and the effect is much larger and more important (remdesivir was only ever shown to marginally decrease length of hospital stay, it was never shown to have any effect on risk of dying).

I understand why pharmaceutical companies don’t like ivermectin. It’s a cheap generic drug. Even Merck, the company that invented ivermectin, is doing it’s best to destroy the drug’s reputation at the moment. This can only be explained by the fact that Merck is currently developing two expensive new covid drugs, and doesn’t want an off-patent drug, which it can no longer make any profit from, competing with them.

The only reason I can think to understand why the broader medical establishment, however, is still so anti-ivermectin is that these studies have all been done outside the rich west. Apparently doctors and scientists outside North America and Western Europe can’t be trusted, unless they’re saying things that are in line with our pre-conceived notions.


And HCQ falls into that same bucket. Even worse - to admit HCQ works would be to admit Trump was right about something.

Liberals would rather that millions die than that Trump be allowed to be right about anything. They hate Trump more than they love their fellow humans.

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195   Patrick   2021 Sep 10, 10:32am  

https://rescue.substack.com/p/pierre-kory-responds-to-critics-hollywood?token=patrick.net


Pierre Kory Responds to Critics, Hollywood Style

How does this passionate New York City-born liberal like it when he reads The Washington Post headline: “How the right’s ivermectin conspiracy theories led to people buying horse dewormer.” In other words, how does he handle all the horse-#&%@ that has been piled on ivermectin the past couple weeks?

He doesn’t like it. He loves it. “Bring it on!” Kory often tells his 120,000 Twitter followers. Nobody ever debates Kory. Here’s why: Kory’s technical round knockout of Dr. Garegnani.

So he was delighted when Florida newspaper publisher Matt Walsh asked him to respond to a ferocious critic of the newspaper’s ivermectin coverage, a critic with real credentials—a University of Michigan professor—in a Q&A debate. “I’ve never had more fun than answering these questions,” Kory says. “It was like shooting fish in a barrel.” ...

Dr. Pierre Kory responds: 63 positive studies exceed most approved drugs
The most easily quantifiable way to describe the indefensible lack of “approval” for ivermectin in COVID-19 is to note the actual amount of supportive clinical trials evidence in COVID-19, both randomized (31) and observational (32), including more than 26,000 patients with the near majority of all studies finding at least some important benefit with treatment.
198   mell   2021 Sep 11, 9:02am  

just_passing_through says
Rin's recipe with a horse paste twist:

http://orthomolecular.org/resources/omns/v17n15.shtml


I'm still positing that sars cov2 is mainly a respiratory virus where it usually does not leave lasting damage (most of the lung damage was from developed pneumonia as confection). However whenever viruses "escape" their infection habitat they can have serious effects, such as high inflammation/clotting in other organs. This is common to many viruses or bacteria and not a unique feature of sars cov2. For example, there are bacteria which are normally found in the mouth region causing no symptoms but when they escape into the GI tract or other parts of the body (e.g. after Trauma/surgery) they can cause serious symptoms. The goal should be to let the infection play out in the resp. tract while reducing viral load actively.
199   Patrick   2021 Sep 11, 10:21am  

https://www.tga.gov.au/media-release/new-restrictions-prescribing-ivermectin-covid-19




It is nothing short of criminal to prohibit doctors from using a life-saving drug.
200   Maga_Chaos_Monkey   2021 Sep 11, 11:21am  

mell says
For example, there are bacteria which are normally found in the mouth region causing no symptoms but when they escape


Those are called opportunistic infections.
201   mell   2021 Sep 11, 11:40am  

just_passing_through says
mell says
For example, there are bacteria which are normally found in the mouth region causing no symptoms but when they escape


Those are called opportunistic infections.


Right. And there are several streptococcus and other species that live in the mouth and cause great havoc if they escape and cause opportunistic infections in other areas of the body (heart, gi tract etc.). I believe sars cov2 is not much different and should be contained to the upper respiratory tract if possible with medications and general good health.
202   Maga_Chaos_Monkey   2021 Sep 11, 11:42am  

mell says
I'm still positing that sars cov2 is mainly a respiratory virus


It is... Some people, I think I've heard Malone above say it, think that perhaps the spike protein was engineered to cause clotting etc., I really don't know. Out of my domain.

Naturally I've understood it infects any cells with an ACE-2 receptor. mRNA vaccines on the other hand can potentially go everywhere.
203   Rin   2021 Sep 11, 5:43pm  

just_passing_through says
Rin's recipe with a horse paste twist:

http://orthomolecular.org/resources/omns/v17n15.shtml


The only thing I'd change on that web site is the fact that both HCQ and Ivermectin are Rx pharmaceuticals, re-purposed for Covid-19, whereas the Rin Pill, Quercetin (or better yet, Quercetin Phytosome) is an all natural dietary supplement.

There is absolutely nothing that the FDA can do to it but slander it or its vendors from saying that it has any effect against Covid, which is fine because some customers can say, "Not only have my allergies subsided but my PCRs for Covid have been negative for the entire past year". The FDA can't throw that customer in jail, only say that he's naive or stupid and remind the vendor that it can't put testimonials on its shipping label but on its website site as an opinion piece/testimonial.
204   Rin   2021 Sep 11, 6:18pm  

just_passing_through says
mell says
For example, there are bacteria which are normally found in the mouth region causing no symptoms but when they escape


Those are called opportunistic infections.


See Rin's Allisure Allicin, it's got a synergy, on the antiviral side as an immunomodulatory agent and on the antibacterial side, containing [ though not 100% eliminating ] the growth of bacterial pathogens w/o the side effects of an antibiotic.
205   Maga_Chaos_Monkey   2021 Sep 11, 9:48pm  

Rin says
Not only have my allergies subsided


I wish I could say that; maybe I will, it's only been about 6 weeks for me so far.
206   Maga_Chaos_Monkey   2021 Sep 11, 9:49pm  

Rin says
Allicin


That was something that was commonly yacked about in the molecular genetics lab I worked in during the late 90s.
207   Maga_Chaos_Monkey   2021 Sep 11, 9:53pm  

mell says
Right. And there are several streptococcus and other species


Yup, 'commonly opportunistic pathogens'.

I used to play with those in my 'micro'biology lab class in school. Fun stuff! Get to play with Bunsen burners, douse the bench with EtOH and light it ON FIRE! to sterilize the work area (mol-bio does this as well but by then that's not the cool stuff)

That class smelled like shit some days though. Depending on what we were growing.
208   Rin   2021 Sep 12, 10:49am  

just_passing_through says

I wish I could say that; maybe I will, it's only been about 6 weeks for me so far.


If you're using Quercetin Dihydrate, drop it, and buy the Quercetin Phytosome.

The former is not very bioavailable and needs all kinds of adjuvants like Bromelain and Olive oil to get any absorption. So for most Dihydrate users, they need to use massive doses like some 2000 to 3000 mg per day to get the same effects as 750-1000 mg of the Phytosome one.
209   Rin   2021 Sep 12, 10:51am  

just_passing_through says
Get to play with Bunsen burners, douse the bench with EtOH and light it ON FIRE! to sterilize the work area


I know of one guy in my lab section, who got kicked out of the group, due to such a stunt in front of the TA.
210   Maga_Chaos_Monkey   2021 Sep 12, 12:12pm  

Rin says
I know of one guy in my lab section, who got kicked out of the group, due to such a stunt in front of the TA.


Odd, that is sterilization protocol.
211   Maga_Chaos_Monkey   2021 Sep 12, 12:13pm  

Rin says
If you're using Quercetin Dihydrate, drop it, and buy the Quercetin Phytosome.


I have Phytosome.
212   Maga_Chaos_Monkey   2021 Sep 12, 12:15pm  

Rin says
who got kicked out


I probably would have been disciplined at least if it was ever found out I was the guy putting dry ice into micro centrifuge tubes and depositing into the trash can of a co-worker I liked to eff with. When they exploded they'd often hit the ceiling.
213   Robert Sproul   2021 Sep 12, 12:33pm  

Rin says
If you're using Quercetin Dihydrate, drop it, and buy the Quercetin Phytosome.

Dang it I just reordered. Q is getting scarce on the online vitamin sites BTW. If it doesn't specify on the bottle it is Dihydrate do you reckon?
214   Rin   2021 Sep 12, 5:22pm  

Robert Sproul says
If it doesn't specify on the bottle it is Dihydrate do you reckon?


It should say Quercetin Dihydrate in the ingredient list, not on the label.
215   Rin   2021 Sep 12, 5:23pm  

just_passing_through says
I have Phytosome.


The ppl I know, who got rid of their allergies, used some 2000 mg of Turmeric w/ bioperine along with 1000 mg of Quercetin.
216   Maga_Chaos_Monkey   2021 Sep 12, 5:40pm  

I eat a little tumeric with eggs (plus pepper and bacon fat) each morning but that much, nor have I tried that high of a Quercetin dose. I'll try it out.
217   Patrick   2021 Sep 12, 5:43pm  

Mmmm, bacon fat. I used to throw it out, but that was insane!

It's tastier than butter, and a "free" byproduct of cooking bacon. And I honestly think it's not that bad for you.

I really like turmeric too. My sister sent me a big container of it and it makes a nice addition to lots of things for the flavor. And if there really is a health benefit, then that's a bonus.
218   Maga_Chaos_Monkey   2021 Sep 12, 5:46pm  

Patrick says
And I honestly think it's not that bad for you.


It isn't. Fat doesn't make you fat, low fat food items do. Shit the store that says fat free or low fat I stay away from.

You need saturated fat for your brain among other things.

Just stay away from polyunsaturated fats - what they've been pushing on us the past 50 years. "vegetable oil" is really "seed oil", full of omega-6 which is highly inflammatory and will fuck up your arteries.

Eat butter too. And olive oil, coconut oil, avacado oil and beef tallow.
219   Maga_Chaos_Monkey   2021 Sep 12, 5:48pm  

Patrick says
I really like turmeric too.


I have a big bin of it but to make it work pharmaceutically it needs to be fresh and mine isn't. Buy the root and grind it yourself and eat it within 2-3 weeks. The sooner the better.

Otherwise it's just adding color and flavor.
220   Patrick   2021 Sep 12, 5:51pm  

just_passing_through says
Eat butter too. And olive oil, coconut oil, avacado oil and beef tallow.



I am a convert to your religion!

They all sound good to me.

I like fresh turmeric too, it's kind of like ginger.
221   Maga_Chaos_Monkey   2021 Sep 12, 5:58pm  

I lost a lot of weight switching to real animal fats and lowering my carbs, my cooking got better and I eat less because I'm satiated quicker and longer. I can actually fast for long periods quite easily now that my body learned to burn fat.

Carb addicts may have a hard time at first until their body is retrained. It takes a while. Fortunately I've always sort of eaten that way so it wasn't hard for me.

Lately I've been eating broccoli sprouts daily. #1 super food. I grow it in mason jars. Check out some of Dr. Rhonda Patrick's videos. She's pretty awesome.
222   Patrick   2021 Sep 12, 5:59pm  

I'm trying to eat nothing with any cane sugar in it for all of September.

It's rather difficult. I think I'm making it up in alcohol.
223   Maga_Chaos_Monkey   2021 Sep 12, 6:00pm  

Oh, and fish oil. I just supplement with that or eat fish. Lately lots of shrimp too to counteract any iodine issues from the broccoli sprouts. I should really start eating smoked oysters for zinc or something.
224   Patrick   2021 Sep 12, 6:02pm  

I still tend to eat fish on Friday, just because it was a thing when I was growing up. And because I like fish.
225   HeadSet   2021 Sep 12, 7:59pm  

just_passing_through says
Eat butter too. And olive oil, coconut oil, avacado oil and beef tallow.

Coconut oil is on the good list? I thought is was as bad as vegetable oil. Coconut oil has cooking advantages, so I want it to be healthy.
226   Shaman   2021 Sep 12, 8:32pm  

My dietician wife says coconut oil is fine.
We use it for cooking a fair bit.
227   Patrick   2021 Sep 12, 10:07pm  

It makes good popcorn.
228   Maga_Chaos_Monkey   2021 Sep 13, 5:13am  

Ghee and clarified butter have a relatively high smoke point.
230   Karloff   2021 Sep 13, 1:49pm  

There's accusations that hospitals in Australia are now treating vaxxed covid patients with Ivermectin, but not unvaxxed.

https://gab.com/Arturo1960/posts/106921705547994992

Evil, murderous swine if this is true.
233   Rin   2021 Sep 14, 10:32am  

just_passing_through says
Buy the root and grind it yourself and eat it within 2-3 weeks.


I have an herbalist in Boston do that for me, every month with fresh peppercorn and olive oil.

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